Continuous Renal Replacement Therapy (DBCOND0025750)

Identifiers

Synonyms

Continuous Renal Replacement Therapy (CRRT) / Continuous renal replacement therapy / Continuous renal replacement therapy (procedure) / Haemofiltration / Hemofiltration / Hemofiltration (procedure)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Calcium chloride	An ionic compound used for the treatment of hypocalcemia and hyperkalemia, and as an antidote to magnesium intoxication due to overdosage of magnesium sulfate.	Protein S100-A13target
D-glucose	A most commonly occurring isomer of glucose used as a carbohydrate supplementation in case of nutrient deprivation and metabolic disorders, such as hypoglycemia.	Hexokinase-1enzyme Hexokinase-4enzyme Solute carrier family 2, facilitated glucose transporter member 1transporter Solute carrier family 2, facilitated glucose transporter member 2transporter Solute carrier family 2, facilitated glucose transporter member 3transporter Solute carrier family 2, facilitated glucose transporter member 4transporter Solute carrier family 2, facilitated glucose transporter member 5transporter Solute carrier family 2, facilitated glucose transporter member 6transporter Solute carrier family 2, facilitated glucose transporter member 7transporter Solute carrier family 2, facilitated glucose transporter member 8transporter Solute carrier family 2, facilitated glucose transporter member 9transporter Solute carrier family 2, facilitated glucose transporter member 10transporter Solute carrier family 2, facilitated glucose transporter member 11transporter Solute carrier family 2, facilitated glucose transporter member 12transporter Sodium/glucose cotransporter 1transporter Sodium/glucose cotransporter 2transporter Albumincarrier
Magnesium chloride	An ionic compound and source of magnesium used for electrolyte replenishment and conditions associated with magnesium deficiencies.	No drug targets
Sodium chloride	An ingredient found in a variety of nutritional products as a source of electrolytes and water.	No drug targets
Sodium phosphate, monobasic	A source of phosphorus used prevent or correct hypophosphatemia in patients with restricted or no oral intake.	Sodium-dependent phosphate transporter 1transporter Sodium-dependent phosphate transporter 2transporter Sodium-dependent phosphate transport protein 2Atransporter Sodium-dependent phosphate transport protein 2Btransporter Sodium-dependent phosphate transport protein 2Ctransporter

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05399537	Safety Evaluation of Prismocitrate 18 in Patients Receiving CRRT	No drug interventions	treatment	3	recruiting
NCT02860130	Clinical Evaluation of Use of Prismocitrate 18 in Patients Undergoing Acute Continuous Renal Replacement Therapy (CRRT)	Citric acid	treatment	3	terminated
NCT06369064	Continuous Veno-venous Hemodialysis and Continuous Veno-venous Hemodiafiltration on Urea Reduction Rate in Intensive Care Patient	No drug interventions	treatment	Not Available	not_yet_recruiting
NCT05450185	Filter Lifespan in Continuous Renal Replacement Therapy	No drug interventions	Not Available	Not Available	recruiting
NCT03144349	Diagnosis Accuracy of Hemoconcentration to Detect Hypovolemia During CRRT	No drug interventions	Not Available	Not Available	unknown_status
NCT04792424	No Monitoring of Post-filter Ionized Calcium in Regional Citrate Anticoagulation	No drug interventions	treatment	Not Available	completed
NCT02034448	CRRTNet Registry- A Prospective Observational Registry	No drug interventions	Not Available	Not Available	unknown_status
NCT03897582	Beta-Lactams Dosing In Pneumonia in ICU in Patients Treated by Continuous Renal Replacement Therapy: the BLIPIC Study	No drug interventions	Not Available	Not Available	recruiting
NCT06425289	Macrohemodynamic Impact of Fluid Removal With Net Ultrafiltration in Patients With Continuous Renal Replacement Therapy	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT01405092	Continuous Versus Conventional Volume Management During CRRT (Continuous Renal Replacement Therapy)	No drug interventions	supportive_care	Not Available	completed
NCT04959110	Citrate Pharmacokinetics in Critically Ill Liver Failure Patients Receiving CRRT	No drug interventions	diagnostic	Not Available	completed
NCT04114747	Renal Physiology During Continuous Renal Replacement Therapy	No drug interventions	prevention	Not Available	recruiting
NCT04071171	Comparison of Biphozyl® and Phoxilium® as a Replacement Fluid During CVVH for AKI in Adults and Their Effects on pH-, Bicarbonate-levels and Respiratory Situation	Calcium chloride Magnesium chloride Potassium chloride Sodium bicarbonate Sodium chloride Sodium phosphate, dibasic	treatment	2	completed
NCT04103307	Continuous Renal Replacement Therapy for Acute Kidney Injury by Cooling Blood	No drug interventions	treatment	2	withdrawn
NCT04537975	C2Rx Hemofiltration Treatment in Severe or Critically Ill Adults With COVID-19	No drug interventions	treatment	Not Available	withdrawn
NCT03314363	Plasma CO2 Removal Due to CRRT and Its Influence on Indirect Calorimetry	No drug interventions	diagnostic	Not Available	completed
NCT06021080	Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions	No drug interventions	Not Available	Not Available	recruiting
NCT04315623	RCA for CRRT in Hyperlactatemia Patient With Increased Bleeding Risk	No drug interventions	treatment	Not Available	unknown_status