Parenteral Nutrition (DBCOND0033953)

Identifiers

Synonyms

Parenteral nutrition / Intravenous feeding of patient (procedure) / Parenteral Feeding / Intravenous Feeding

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Alanyl glutamine	A dipeptide consisting of alanine and glutamine used for supplementation.	No drug targets
Amino acids	Mixture of amino acids ; used for parenteral nutrition in infants.	No drug targets
Calcium chloride	An ionic compound used for the treatment of hypocalcemia and hyperkalemia, and as an antidote to magnesium intoxication due to overdosage of magnesium sulfate.	Protein S100-A13target
D-glucose	A most commonly occurring isomer of glucose used as a carbohydrate supplementation in case of nutrient deprivation and metabolic disorders, such as hypoglycemia.	Hexokinase-1enzyme Hexokinase-4enzyme Solute carrier family 2, facilitated glucose transporter member 1transporter Solute carrier family 2, facilitated glucose transporter member 2transporter Solute carrier family 2, facilitated glucose transporter member 3transporter Solute carrier family 2, facilitated glucose transporter member 4transporter Solute carrier family 2, facilitated glucose transporter member 5transporter Solute carrier family 2, facilitated glucose transporter member 6transporter Solute carrier family 2, facilitated glucose transporter member 7transporter Solute carrier family 2, facilitated glucose transporter member 8transporter Solute carrier family 2, facilitated glucose transporter member 9transporter Solute carrier family 2, facilitated glucose transporter member 10transporter Solute carrier family 2, facilitated glucose transporter member 11transporter Solute carrier family 2, facilitated glucose transporter member 12transporter Sodium/glucose cotransporter 1transporter Sodium/glucose cotransporter 2transporter Albumincarrier
Dextrose, unspecified form	A form of glucose used for caloric supply and the replenishment of fluid in total parenteral nutrition and other therapies as well as for the treatment of hypoglycemic episodes.	Hexokinase-4enzyme Hexokinase-1enzyme Solute carrier family 2, facilitated glucose transporter member 1transporter Solute carrier family 2, facilitated glucose transporter member 2transporter Solute carrier family 2, facilitated glucose transporter member 3transporter Solute carrier family 2, facilitated glucose transporter member 4transporter Solute carrier family 2, facilitated glucose transporter member 6transporter Solute carrier family 2, facilitated glucose transporter member 7transporter Solute carrier family 2, facilitated glucose transporter member 8transporter Solute carrier family 2, facilitated glucose transporter member 9transporter Solute carrier family 2, facilitated glucose transporter member 10transporter Solute carrier family 2, facilitated glucose transporter member 11transporter Solute carrier family 2, facilitated glucose transporter member 12transporter Sodium/glucose cotransporter 1transporter
Fish oil	A source of essential fatty acids used as a source of calories in parenteral nutrition and as a dietary supplement.	Diacylglycerol O-acyltransferase 2target Prostaglandin G/H synthase 2target Free fatty acid receptor 4target Voltage gated L-type calcium channeltarget Sodium channel proteintarget Free radicalstarget Nuclear factor NF-kappa-Btarget Sterol regulatory element-binding protein 1target Peroxisome proliferator-activated receptor alphatarget Peroxisome proliferator-activated receptor gammatarget Peroxisome proliferator-activated receptor deltatarget Cytochrome P450 3A4enzyme
Lactic acid	An emollient and keratolytic used agent in various cosmetic products and used as an additive in various pharmaceutical products for its antibacterial properties.	Bifunctional protein PutAtarget NimA-related proteintarget Monocarboxylate transporter 2transporter Solute carrier organic anion transporter family member 2B1transporter Monocarboxylate transporter 1transporter Monocarboxylate transporter 10transporter Solute carrier organic anion transporter family member 2A1transporter Monocarboxylate transporter 4transporter
Linoleic acid	Not Annotated	Fatty acid-binding protein, adipocytetarget
Manganese cation	A transition metal used for supplementation of manganese during Total Parenteral Nutrition (TPN).	Cytoplasmic aconitate hydrataseenzyme Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrialtarget Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialtarget TGF-beta-activated kinase 1 and MAP3K7-binding protein 1target Arginase-1target Serotransferrincarrier Albumincarrier Metal cation symporter ZIP14transporter Superoxide dismutase [Mn], mitochondrialtarget Glutamine synthetasetarget Phosphoenolpyruvate Carboxykinasestarget Natural resistance-associated macrophage protein 2transporter Calcium/manganese antiporter SLC30A10transporter Ceruloplasmincarrier Transient receptor potential cation channel subfamily M member 7transporter Serine/threonine-protein phosphatase PP1-gamma catalytic subunittarget
Manganese gluconate	An ingredient found in a variety of supplements and vitamins.	No drug targets
Medium-chain triglycerides	A source of essential fatty acids used as a source of calories in parenteral nutrition.	Albumincarrier
Olive oil	In a clinical context, olive oil is used as a source of calories and fatty acids in patients requiring parenteral nutrition. A formulation called Clinolipid, comprising olive oil and soybean...	No drug targets
Omega-3 fatty acids	An ingredient found in a variety of supplements and vitamins.	Peroxisome proliferator-activated receptor gammatarget Prostaglandin G/H synthase 2enzyme Polyunsaturated fatty acid 5-lipoxygenaseenzyme Peroxisome proliferator-activated receptor alphatarget Sterol regulatory element-binding protein 1target
Potassium chloride	A potassium salt used to treat hypokalemia.	Solute carrier family 12 member 2target Solute carrier family 12 member 1target Solute carrier family 12 member 5target Solute carrier family 12 member 6target Solute carrier family 12 member 7target Solute carrier family 12 member 4target Solute carrier family 12 member 2transporter Solute carrier family 12 member 1transporter Solute carrier family 12 member 5transporter Solute carrier family 12 member 6transporter Solute carrier family 12 member 7transporter Solute carrier family 12 member 4transporter
Selenious acid	An ingredient found in supplements, vitamins, parenteral nutrition, and dandruff shampoo.	Glutathione peroxidase 1enzyme Selenoprotein Ptransporter Thioredoxin reductase 1, cytoplasmicenzyme
Sodium acetate	A compound used for electrolyte replenishment and total parenteral nutrition (TPN) therapy.	Acetyl-coenzyme A synthetase, cytoplasmicenzyme
Sodium chloride	An ingredient found in a variety of nutritional products as a source of electrolytes and water.	No drug targets
Sodium fluoride	An ingredient of various dental preparations used to support tooth mineralization and the prevention of dental caries.	Hydroxyapatitetarget Enolase-phosphatase E1enzyme Enolaseenzyme Enolaseenzyme Enolaseenzyme Enolaseenzyme
Sodium hydroxide	Used to destroy or kill the nail matrix (matrixectomies) .	No drug targets
Sodium phosphate, monobasic	A source of phosphorus used prevent or correct hypophosphatemia in patients with restricted or no oral intake.	Sodium-dependent phosphate transporter 1transporter Sodium-dependent phosphate transporter 2transporter Sodium-dependent phosphate transport protein 2Atransporter Sodium-dependent phosphate transport protein 2Btransporter Sodium-dependent phosphate transport protein 2Ctransporter
Soybean oil	An oil used as a source of calories and essential fatty acids in selected patients for total parenteral nutrition (TPN) therapy and prevention of essential fatty acid deficiency.	Peroxisome proliferator-activated receptor alphatarget
Teduglutide	A glucagon-like peptide-2 (GLP-2) analog used to treat patients with Short Bowel Syndrome (SBS) who require parenteral nutritional support.	Glucagon-like peptide 2 receptortarget
Vitamin E	An antioxidant vitamin used in many skin creams and multivitamin preparations.	SEC14-like protein 4target SEC14-like protein 3target SEC14-like protein 2target Nuclear receptor subfamily 1 group I member 2target Protein kinase C beta typetarget Polyunsaturated fatty acid 5-lipoxygenasetarget Protein kinase C alpha typetarget Diacylglycerol kinase alphatarget Serine/threonine-protein phosphatase 2A catalytic subunit beta isoformtarget Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoformtarget Alpha-tocopherol transfer proteincarrier Glutathione S-transferase A2enzyme Glutathione S-transferase Penzyme Glutathione S-transferase omega-1enzyme Glutathione S-transferase Mu 3enzyme Glutamate--cysteine ligase catalytic subunitenzyme NAD(P)H dehydrogenase [quinone] 1enzyme Heme oxygenase 1enzyme Superoxide dismutase [Cu-Zn]enzyme Scavenger receptor class B member 1transporter Phospholipid-transporting ATPase ABCA1transporter NPC1-like intracellular cholesterol transporter 1transporter ATP-binding cassette sub-family G member 1transporter SEC14-like protein 2carrier SEC14-like protein 3carrier Phospholipid transfer proteincarrier Cytochrome P450 3A4enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT00292279	The Impact of Omega-3 Fat Emulsion on Clinical Outcome of Post-Operative Cancer Patients	Aloe vera leaf Coconut oil Fish oil Hyaluronic acid Propylene glycol Rosemary Soybean oil	treatment	3	completed
NCT00672854	Study Comparing a Soybean Oil-Based With an Olive Oil-Based Lipid Emulsion in ICU Patients Requiring TPN	Aloe vera leaf Coconut oil Hyaluronic acid Olive oil Propylene glycol Rosemary Soybean oil	treatment	2 / 3	completed
NCT06525753	Weaning is Winning? (WeWin Study)	No drug interventions	Not Available	Not Available	recruiting
NCT03284398	Three-Chamber Bags Retrospective Study in Spain	No drug interventions	Not Available	Not Available	completed
NCT05519761	A Retrospective, Observational, Multicenter Study to Evaluate the Safety and Performance of POLYSITE® and SEESITE® Implantable Ports	No drug interventions	Not Available	Not Available	unknown_status
NCT05337228	Clinical Trial to Evaluate the Safety and Efficacy of IN-C006 Peri Inj. Compared With RPN301	No drug interventions	supportive_care	3	completed
NCT05788588	A Phase Ⅲ Study of HR19006 Injection in Postsurgical Parenteral Nutrition	Benzoyl peroxide	supportive_care	3	active_not_recruiting
NCT01814956	Different Lipid Emulsions in Acute Lung Injury Patients	No drug interventions	treatment	4	terminated
NCT06573632	Perioperative TPN Improves Surgical Outcomes	No drug interventions	Not Available	Not Available	completed
NCT05299099	Clinical Trial to Evaluate the Safety and Efficacy of IN-C006 Inj. Compared With RCN301	No drug interventions	supportive_care	3	completed
NCT04816734	Initial Parenteral Nutrition Education of Parent Assessment Plan	No drug interventions	prevention	Not Available	completed
NCT04006730	Analysis of the Pharmaceutical Validation of Picc Line Installation Requests at the Nîmes University Hospital	No drug interventions	Not Available	Not Available	completed
NCT06510348	Achieving nuTritional Target in criticAlly Ill patieNts With iMpairEd gastroiNtesTinal Dysfunction	No drug interventions	supportive_care	Not Available	not_yet_recruiting
NCT00512629	Cholestasis Prevention: Efficacy of IV Fish Oil	Fish oil Soybean oil	prevention	1	completed
NCT02463812	Lipid Infusion Following Major Surgery	Soybean oil	treatment	Not Available	withdrawn
NCT00865150	Amino Acid and Acylcarnitine Profiles in Premature Neonates	No drug interventions	Not Available	Not Available	completed
NCT02828150	Integrative Parenteral Nutrition in Cancer Patients	No drug interventions	treatment	Not Available	completed
NCT04234490	Longitudinal Evaluation of the Impact of Parenteral Nutrition	No drug interventions	Not Available	Not Available	completed
NCT05519787	A Retrospective, Observational, Monocenter, Study to Describe the Utilization and Overall Safety and Performance of POLYSITE®/SEESITE® Implantable Ports	No drug interventions	Not Available	Not Available	completed
NCT03693287	Personalized vs Standardized PN for Preterm Infants >1250g	No drug interventions	treatment	4	recruiting
NCT03149653	Crossover Study on the Effect of Omegaven in Combination With Different Lipid Emulsions in Home Parenteral Nutrition	Fish oil Medium-chain triglycerides Olive oil Omega-3 fatty acids Soybean oil	treatment	4	completed
NCT03278847	Optimising Newborn Nutrition During Therapeutic Hypothermia.	No drug interventions	Not Available	Not Available	completed
NCT03157245	Incidence of Deep Vein Thrombosis on Central Venous Catheters in the Post Operative Period of Carcinologic Surgery	No drug interventions	Not Available	Not Available	unknown_status
NCT04234152	Complete Shielding of Multivitamins to Reduce Toxic Peroxides in the Parenteral Nutrition: A Pilot Study	No drug interventions	prevention	Not Available	completed
NCT03792100	Efficacy & Safety of SmofKabiven Emulsion for Infusion vs Hospital Compounded "All in One" for Parenteral Nutrition	Alanine Aloe vera leaf Arginine Calcium chloride Coconut oil D-glucose Fish oil Glycine Histidine Hyaluronic acid Isoleucine Leucine Lysine Magnesium sulfate Medium-chain triglycerides Methionine Olive oil Phenylalanine Potassium chloride Proline Propylene glycol Rosemary Serine Sodium acetate Sodium glycerophosphate Soybean oil Taurine Threonine Tryptophan Tyrosine Valine Zinc sulfate	treatment	3	completed
NCT01839617	Study Comparing Early and Late Nutrition in Cancer Patients Undergoing Abdominal Surgery	No drug interventions	treatment	Not Available	unknown_status
NCT05619224	Physiotherapy to Improve Feeding Skills in Preterm Infants	No drug interventions	treatment	Not Available	enrolling_by_invitation
NCT03606863	Peripheral Parenteral Nutrition vs Conventional Fluid in Colorectal Resection in ERAS	No drug interventions	treatment	3	unknown_status
NCT06234163	The Effect of Enteral and Parenteral Nutrition Training	No drug interventions	health_services_research	Not Available	completed
NCT00392730	Neurodevelopment and Neuroimaging in Parenterally-fed Infants and Young Children	No drug interventions	Not Available	Not Available	completed
NCT00321165	The AOT (Acridine Orange and Taurolidine) Trial	Taurolidine	prevention	3	completed
NCT00451646	Study Comparing the Safety and Tolerance of SMOFlipid 20% in Long-term Treatment With Parenteral Nutrition	Soybean oil	treatment	3	completed
NCT00798681	Evaluating the Influence of Ready-to-use (RTU) Parenteral Nutrition in the Clinical Outcome of Patients Study	No drug interventions	treatment	4	completed
NCT01176695	Efficacy and Safety of a Fish Oil Containing Lipid Emulsion	Aloe vera leaf Coconut oil Fish oil Hyaluronic acid Propylene glycol Rosemary	treatment	3	completed
NCT06161350	The Multi-disciplinary Approach of Children With Feeding Difficulties and Tube Feeding in UZB Between 2000 and 2021	No drug interventions	Not Available	Not Available	enrolling_by_invitation