Carcinoid Syndrome (DBCOND0042109)

Identifiers

Synonyms

Carcinoid syndrome / Malignant Carcinoid Syndrome / Carcinoid syndrome (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Lanreotide	A somatostatin analog used for the treatment of unresectable, well- or moderately-differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors and acromegaly.	Somatostatin receptor type 2target Somatostatin receptor type 5target Cytochrome P450 3A4enzyme

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT01018953	Study to Assess the Efficacy and Safety of Different Doses of BIM 23A760 in Patients With Carcinoid Syndrome	Dopastatin	treatment	2	terminated
NCT04993261	An Investigational Scan (Dual Energy CT) in Detecting Gastrointestinal Carcinoid Tumors	No drug interventions	diagnostic	0	active_not_recruiting
NCT03722511	Evaluating an Amino Acid Based Medical Food w/ Diarrhea in Carcinoid Syndrome & Other NETs	No drug interventions	supportive_care	2	completed
NCT01430871	Effects of Serotonin Excess on Bone in Carcinoid Syndrome	No drug interventions	Not Available	Not Available	completed
NCT04073017	Enterade in Carcinoid/Non-Carcinoid Syndrome Neuroendocrine Tumor Patients With Quality of Life Limiting Bowel Frequency	No drug interventions	supportive_care	Not Available	terminated
NCT01172717	Study of Panitumumab in the Treatment of Carcinoid Syndrome	Panitumumab	treatment	2	withdrawn
NCT04039516	Carcinoid Heart Disease and Peptide Receptor Radiotargetted Therapy	Lutetium Lu 177 dotatate	treatment	2	not_yet_recruiting
NCT00774930	An Efficacy and Safety Study of Somatuline Depot (Lanreotide) Injection to Treat Carcinoid Syndrome	Lanreotide	treatment	3	completed
NCT04776876	Retifanlimab (INCMGA00012) and Telotristat Ethyl for the Treatment of Advanced Neuroendocrine Tumors and Carcinoid Syndrome	Retifanlimab Telotristat ethyl	treatment	2	withdrawn
NCT03453489	AMT-PET in Monitoring Telotristat Etiprate Treatment in Participants With MetastaticNeuroendocrine Neoplasm	Telotristat ethyl Tryptophan	treatment	2	recruiting
NCT01234168	A Study to Assess Neuroendocrine Tumour (NET) Patients Currently Treated by Somatuline Autogel for History of Carcinoid Syndrome Associated With Episodes of Diarrhea	No drug interventions	Not Available	Not Available	completed
NCT05361668	Study to Evaluate the Safety, PK, and Dose Response of Paltusotine in Subjects With Carcinoid Syndrome	Paltusotine	treatment	2	active_not_recruiting
NCT04713202	Prospective Assessment of Patients With Neuroendocrine Tumors and Current or Prior History of Carcinoid Syndrome or Diarrhea Undergoing Peptide Receptor Radionuclide Therapy With or Without Telotristat Ethyl	Telotristat ethyl	supportive_care	2	withdrawn
NCT00853047	Study of Telotristat Etiprate (LX1606) in Participants With Symptomatic Carcinoid Syndrome Not Managed by Stable-Dose Octreotide Therapy	Octreotide Telotristat ethyl	treatment	2	completed
NCT01932528	An Open-label Study to Evaluate the Absorption, Metabolism, and Excretion of [14C]-Telotristat Etiprate in Males	Telotristat ethyl	treatment	1	completed
NCT03223428	Real-world Evidence Study EvaLuating PAtient-Reported Outcomes With XERMELO	Telotristat ethyl	Not Available	Not Available	completed
NCT04140409	Sandostatin (Octreotide LAR) May Lead to Clinical Improvement Through Receptor Occupation Optimisation	Octreotide	treatment	4	terminated
NCT00884715	Pharmacokinetics, Efficacy and Safety of an Octreotide Implant in Patients With Carcinoid Syndrome	Octreotide	treatment	1 / 2	terminated
NCT01104415	Study of Telotristat Etiprate (LX1606) in Participants With Symptomatic Carcinoid Syndrome	Telotristat ethyl	treatment	2	completed
NCT02063659	Telotristat Etiprate for Carcinoid Syndrome Therapy	Telotristat ethyl	treatment	3	completed
NCT02026063	Telotristat Etiprate - Expanded Treatment for Patients With Carcinoid Syndrome Symptoms	Telotristat ethyl	treatment	3	completed
NCT01677910	TELESTAR (Telotristat Etiprate for Somatostatin Analogue Not Adequately Controlled Carcinoid Syndrome)	Telotristat ethyl	treatment	3	completed
NCT05064514	Investigation of a Transcatheter Tricuspid Valved Stent Graft in Patients With Carcinoid Heart Disease	No drug interventions	treatment	Not Available	active_not_recruiting
NCT05756608	Fibrosis in Chronic and Delayed Myocardial Infarction	No drug interventions	Not Available	Not Available	recruiting