Myocardial Perfusion Imaging (DBCOND0048997)

Identifiers

Synonyms

MPS I / MPI / Myocardial perfusion scan / Scan myocardial perfusion / Radionuclide myocardial perfusion study (procedure) / Radionuclide imaging of heart for assessment of myocardial viability (procedure) / Scan NOS myocardial perfusion / Mucopolysaccharidosis, type I / Mucopolysaccharidosis I / Mucopolysaccharidosis, MPS-I (disorder)

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Adenosine	A medication used in myocardial perfusion scintigraphy and to treat supraventricular tachycardia.	Adenosine receptor A3target Adenosine deaminaseenzyme Adenosine kinaseenzyme Adenosine receptor A1target Adenosine receptor A2atarget Adenosine receptor A2btarget Solute carrier family 28 member 3transporter Equilibrative nucleoside transporter 1transporter Equilibrative nucleoside transporter 2transporter Equilibrative nucleoside transporter 3transporter Equilibrative nucleoside transporter 4transporter Sodium/nucleoside cotransporter 1transporter Sodium/nucleoside cotransporter 2transporter Gap junction alpha-1 proteintransporter Adenylate kinase isoenzyme 1enzyme Nucleoside diphosphate kinase Aenzyme Nucleoside diphosphate kinase Benzyme Purine nucleoside phosphorylaseenzyme Xanthine dehydrogenase/oxidaseenzyme Albumincarrier
Dipyridamole	A phosphodiesterase inhibitor used to prevent postoperative thromboembolic events.	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Atarget cGMP-specific 3',5'-cyclic phosphodiesterasetarget 3',5'-cyclic-AMP phosphodiesterase 4Atarget Adenosine deaminasetarget ATP-binding cassette sub-family C member 4transporter ATP-binding cassette sub-family C member 5transporter ATP-dependent translocase ABCB1transporter Calcipressin-1target Alpha-1-acid glycoprotein 1target Solute carrier organic anion transporter family member 1B1transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 2B1transporter Bile salt export pumptransporter
Gadobutrol	A gadolinium-based contrast agent (GBCA) used with contrasted magnetic resonance imaging (MRI) to detect and visualize lesions and abnormal vascularity.	No drug targets
Sodium bicarbonate	A compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock.	Electrogenic sodium bicarbonate cotransporter 1transporter Sodium bicarbonate cotransporter 3transporter Electroneutral sodium bicarbonate exchanger 1transporter Electrogenic sodium bicarbonate cotransporter 4transporter Hydrogen ionstarget Sodium-driven chloride bicarbonate exchangertransporter Voltage-dependent T-type calcium channel subunit alpha-1Htarget A-type voltage-gated potassium channel KCND3target
Tetrakis(2-methoxyisobutylisocyanide)copper(I) tetrafluoroborate	Tetrakis (2-methoxyisobutylisocyanide) copper (I) tetrafluoroborate is a component of Cardiolite, a technetium Tc99m-based imaging agent used for assessing myocardial perfusion.	No drug targets
Tetrofosmin	A diphosphine complexed with technetium 99 used for imaging to determine myocardial ischemia, infarcted myocardium, and assessment of left ventricular function.	No drug targets

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT04532047	In Utero Enzyme Replacement Therapy for Lysosomal Storage Diseases	Alglucosidase alfa Elosulfase alfa Galsulfase Idursulfase Laronidase Sebelipase alfa Vestronidase alfa	treatment	1	recruiting
NCT03333200	Longitudinal Study of Neurodegenerative Disorders	No drug interventions	Not Available	Not Available	recruiting
NCT04958070	The Intensively Follow-up Examinations for Asymptomatic MPS I Infants in Taiwan	No drug interventions	Not Available	Not Available	recruiting
NCT05665036	Safety and Efficacy of Encapsulated Allogeneic MPS-1 Therapy	No drug interventions	treatment	1 / 2	withdrawn
NCT01572636	Laronidase (Aldurazyme TM) Enzyme Replacement Therapy With Hematopoietic Stem Cell Transplant for Hurler Syndrome	Laronidase	Not Available	Not Available	terminated
NCT02067650	Ultrasound Findings of Finger, Wrist and Knee Joints in Mucopolysaccharidosis	No drug interventions	Not Available	Not Available	completed
NCT02702115	Ascending Dose Study of Genome Editing by the Zinc Finger Nuclease (ZFN) Therapeutic SB-318 in Subjects With MPS I	Devafidugene civaparvovec	treatment	1 / 2	terminated
NCT03937921	Dotarem Evaluation for Myocardial Perfusion CMR	Gadobutrol	Not Available	Not Available	recruiting
NCT03864497	Myocardial Perfusion Imaging in Liver Transplantation Candidates	No drug interventions	Not Available	Not Available	completed
NCT06047028	'Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability	No drug interventions	Not Available	Not Available	recruiting
NCT03150342	Presentations of Hypertrophic Cardiomyopathy on Myocardial Perfusion Imaging	No drug interventions	Not Available	Not Available	unknown_status
NCT03917199	Utility of Regadenoson Low-dose Dynamic Computed Tomography for Myocardial Perfusion Assesment (ULYSSES Study).	No drug interventions	Not Available	Not Available	completed
NCT03173716	Real-Time Myocardial Perfusion Echocardiography in the ICU	No drug interventions	diagnostic	4	completed
NCT03084562	Regadenoson vs Dipyridamole in Use as Pharmacological Stress Agent Before SPECT	No drug interventions	Not Available	Not Available	completed
NCT04599192	Fractional Flow Reserve and Instantaneous Free-wave Ratio Revascularization Strategies in Women	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT01221272	Effect of Ranolazine on Myocardial Perfusion Assessed by Serial Quantitative Exercise SPECT Imaging	Ranolazine	treatment	4	completed
NCT04465526	The Influence of Coronary Chronic Total Occlusion on Myocardial Perfusion on Computed Tomography	No drug interventions	Not Available	Not Available	completed
NCT03180060	Meta-Analysis of Stress Myocardial Perfusion Imaging	No drug interventions	Not Available	Not Available	completed
NCT01490294	Myocardial Perfusion MRI	Gadobutrol	diagnostic	2	completed