Adult Onset Growth Hormone Deficiency (DBCOND0072078)

Identifiers

Synonyms
Growth Hormone Deficiency, Adult / Adult-Onset Growth Hormone Deficiency / Adult Growth Hormone Deficiency (AGHD) / Adult Growth Hormone Deficiency / Adults Growth Hormone Deficiency / Adult onset Growth hormone deficiency / Adult-onset growth hormone deficiency (disorder) / Adult growth hormone deficiency (disorder)

Associated Data

Indicated Drugs and Targets
DrugDescriptionTargets
Macimorelin
A medication used to treat adult growth hormone deficiency.
Somatotropin
A recombinant human growth hormone used as replacement therapy in various conditions of growth failure, growth hormone deficiency, and weakness in children and adults.
Clinical Trials
IdentifierTitleDrug(s)PurposePhaseStatus
NCT01088399
A Prospective Observational Study of Effect of Somatropin on Growth Hormone Deficient AdultsNot AvailableNot Availablecompleted
NCT02988687
Metabolic and QOL Effects of GH Treatment in Patients With TBI and AGHDNo drug interventionsNot AvailableNot Availablecompleted
NCT02218710
Bone Structure in Patients With Adult Onset Growth Hormone Deficiency Assessed Using High Resolution Peripheral Quantitative Computed TomographyNo drug interventionsNot AvailableNot Availableunknown_status
NCT02719990
Open-label Extension Study to Evaluate the Safety of Long-term Twice-monthly Administration of Somavaratan in Adult Growth Hormone Deficiency (AGHD)treatment2terminated
NCT01247675
A Safety, Pharmacokinetic and Pharmacodynamic Study of ACP-001 (TransCon hGH) in Adults With Growth Hormone Deficiencytreatment2completed
NCT00294619
Treatment of Adults With Growth Hormone Deficiencytreatment3completed
NCT01109017
Observational Study of the Safety and Efficacy of Norditropin® in Adult Patients With Growth Hormone DeficiencyNot AvailableNot Availablecompleted
NCT01562834
Effect of Somatropin on Left Ventricular Mass in Growth Hormone Deficient Adult Patientstreatment4completed
NCT00519558
Growth Hormone Deficiency in Adults (GHDA)treatment3completed
NCT00184730
Long-term Trial on Growth Hormone Deficiency in Adults (GHDA)treatment3completed
NCT01225666
MOD-4023 (Long-Lasting Human Growth Hormone (hGH)) Study in Growth Hormone Deficient Adults (GHDA)treatment2completed
NCT00931476
A Single Dose Trial in Healthy Caucasians and Japanese Subjects Investigating the Pharmacokinetics of Somatropintreatment1completed
NCT00191360
Extension Study on Safety of Long-Term Growth Hormone Replacement in Adult Patients With Growth Hormone Deficiencytreatment3completed
NCT03075644
A Trial to Evaluate the Safety of Once Weekly Dosing of Somapacitan (NNC0195-0092) and Daily Norditropin® FlexPro® for 52 Weeks in Previously Human Growth Hormone Treated Japanese Adults With Growth Hormone Deficiencytreatment3completed
NCT03104010
A Non-inferiority Phase 2 Study to Evaluate the Safety and Efficacy of PEG-rhGH in the Treatment of AGHDtreatment2unknown_status
NCT01080755
Metabolic Endocrinology and Growth Hormone in AdultsNo drug interventionsNot AvailableNot Availablecompleted
NCT05171855
A Trial to Investigate Long Term Efficacy and Safety of Lonapegsomatropin in Adults With Growth Hormone Deficiencytreatment3active_not_recruiting
NCT00184743
Long-term Trial on Growth Hormone Deficiency in Adults (GHDA)treatment3completed
NCT01282164
The Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and Adrenocorticotropic AxisNo drug interventionsdiagnosticNot Availablecompleted
NCT01706783
A Trial Investigating the Safety, Tolerability, Availability and Distribution in the Body of Once-weekly Long-acting Growth Hormone (Somapacitan) Compared to Once Daily Norditropin NordiFlex® in Adults With Growth Hormone Deficiencytreatment1completed
NCT00960128
Observational Prospective Study on Patients Treated With Norditropin®Not AvailableNot Availablecompleted
NCT00596037
Treatment of Adults With Growth Hormone Deficiencytreatment3completed
NCT05718570
A Study to Follow Patients With Adult Growth Hormone Deficiency (AGHD) Treated With Sogroya® for Long Term Safety InformationNot AvailableNot Availableenrolling_by_invitation
NCT02946606
A Clinical Study in AGHD to Assess Safety, Tolerability and Efficacy of GX-H9treatment2completed
NCT00297713
Study of an Extended-Release, Crystalline Formulation of Recombinant Human Growth Hormone (ALTU-238) in Growth Hormone Deficient Adults to Determine Pharmacokinetics, Pharmacodynamics, and Drug Safetytreatment2completed
NCT04867317
Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)treatment3not_yet_recruiting
NCT00934063
An Observational Study Validating a Score That Quantifies the Therapeutic Response to Treatment With Norditropin®Not AvailableNot Availablecompleted
NCT02382939
A Trial to Compare the Safety of Once Weekly Dosing of Somapacitan With Daily Norditropin® FlexPro® for 26 Weeks in Previously Human Growth Hormone Treated Adults With Growth Hormone Deficiencytreatment3completed
NCT02526420
Versartis International Trial in Adults With Long-Acting Growth Hormonetreatment2completed
NCT03212131
Investigation of Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Multiple Doses of Somapacitan in Subjects With Mild and Moderate Degrees of Hepatic Impairment Compared to Subjects With Normal Hepatic Function.treatment1completed
NCT05979480
The Effects of Growth Hormone Treatment Discontinuation in Adults on Metabolic Profile, Body Composition and Quality Of Life (GAMBOL Study)No drug interventionsNot AvailableNot Availablerecruiting
NCT01543880
Safety and Efficacy of Long-term Somatropin Treatment in AdultsNot AvailableNot Availablecompleted
NCT00715689
Dose Study in Growth Hormone Deficient Adults Investigating Safety, Pharmacokinetics and Pharmacodynamics of NNC126-0083treatment2completed
NCT01698944
Cardiovascular Effects on Growth Hormone Therapy in Adults With Growth Hormone Deficiencytreatment4terminated
NCT01822340
Safety and Efficacy Study of Recombinant Human Growth Hormone in Adult Growth Hormone Deficiency Patientstreatment2completed
NCT05355272
Growth Hormone Replacement in Veterans With GWI and AGHD (GWIT)treatment2recruiting
NCT03186495
Investigation of Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Multiple Doses of Somapacitan in Subjects With Various Degrees of Impaired Renal Function Compared to Subjects With Normal Renal Functiontreatment1completed
NCT05230550
Post-Marketing Surveillance (Special Use-results Surveillance on Long-term Use) With Sogroya®Not AvailableNot Availableenrolling_by_invitation
NCT01909479
A Phase 3, Multicenter Study To Evaluate The Efficacy And Safety Of MOD-4023 In Adults With Growth Hormone Deficiencytreatment3terminated
NCT02229851
Trial to Compare the Efficacy and Safety of NNC0195-0092 (Somapacitan) With Placebo and Norditropin® FlexPro® (Somatropin) in Adults With Growth Hormone Deficiency.treatment3completed
NCT02005198
Assessing the Minimal Important Difference (MID) of the Treatment Related Impact Measure-Adult Growth Hormone Deficiency (TRIM-AGHD)No drug interventionsNot AvailableNot Availablecompleted
NCT01806298
An Open-label Phase 4 Study to Explore Immunogenicity of the Liquid Formulation of Saizen® in Subjects With Adult Growth Hormone Deficiency (AGHD)treatment4completed
NCT01580605
French National Registry of Adults With Growth Hormone Deficiency Treated With SomatropinNot AvailableNot Availablecompleted
NCT01514500
First Human Dose Trial of NNC0195-0092 (Somapacitan) in Healthy Subjectstreatment1completed
NCT00184678
Effect of Growth Hormone on Bone Mineral Density in Young Adults With Child-hood Onset Growth Hormone Deficiencytreatment3completed
NCT01804413
Pegvisomant With Glucagon Test to Assess for Adult Growth Hormone DeficiencydiagnosticNot Availableunknown_status