Menstrual Bleeding, Heavy (DBCOND0157592)

Identifiers

Synonyms

Bleeding menstrual heavy / Heavy Menstrual Bleeding / Excessive and frequent menstruation with regular cycle / Menorrhagia / Menorrhagia (finding) / Hypermenorrhea / Menstrual flow excessive / Hypermenorrhoea / Heavy periods / Excessive menstruation / Menses regular with excessive bleeding / Prolonged heavy periods / Menstruation increased

Associated Data

Indicated Drugs and Targets

Drug	Description	Targets
Elagolix	A gonadotropin releasing hormone receptor antagonist used to treat moderate to severe pain in endometriosis.	Gonadotropin-releasing hormone receptortarget Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2D6enzyme Cytochrome P450 2C8enzyme ATP-dependent translocase ABCB1transporter Solute carrier organic anion transporter family member 1B1transporter UDP-glucuronosyltransferases (UGTs)enzyme
Estradiol	An estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 3transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Neuronal acetylcholine receptor subunit alpha-4target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target UDP-glucuronosyltransferase 2B15enzyme Catechol O-methyltransferaseenzyme UDP-glucuronosyltransferases (UGTs)enzyme Aromataseenzyme
Estradiol valerate	An estradiol prodrug used to treat some effects of menopause, hypoestrogenism, androgen dependant carcinoma of the prostate, and in combination products for endometriosis and contraception.	Estrogen receptortarget Nuclear receptor subfamily 1 group I member 2target Sex hormone-binding globulincarrier Estrogen receptor betatarget Cytochrome P450 1A2enzyme UDP-glucuronosyltransferase 1A1enzyme Albumincarrier Fatty acid-binding protein, intestinalcarrier Cytochrome P450 3A4enzyme Cytochrome P450 3A5enzyme Cytochrome P450 3A7enzyme Solute carrier family 22 member 2transporter Solute carrier family 22 member 1transporter Solute carrier family 22 member 3transporter Solute carrier organic anion transporter family member 2B1transporter Solute carrier organic anion transporter family member 1A2transporter ATP-binding cassette sub-family C member 10transporter Solute carrier family 22 member 11transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Solute carrier organic anion transporter family member 1B1transporter ATP-dependent translocase ABCB1transporter Cytochrome P450 1A1enzyme Cytochrome P450 1B1enzyme Cytochrome P450 2C19enzyme Cytochrome P450 2C8enzyme Cytochrome P450 2C9enzyme Organic anion transporter 3transporter Solute carrier organic anion transporter family member 1B3transporter Solute carrier organic anion transporter family member 1C1transporter Solute carrier organic anion transporter family member 4A1transporter Neuronal acetylcholine receptor subunit alpha-4target Nuclear receptor coactivator 2target G-protein coupled estrogen receptor 1target ATP synthase subunit atarget Beclin-1target 17-beta-hydroxysteroid dehydrogenase type 2target Estrogen-related receptor gammatarget
Levonorgestrel	A progestin found in oral and IUD contraceptives and at higher doses in emergency contraceptives.	Progesterone receptortarget Estrogen receptortarget 3-oxo-5-alpha-steroid 4-dehydrogenase 1target Cytochrome P450 3A4enzyme Androgen receptortarget Sex hormone-binding globulintarget Glucocorticoid receptortarget Cytochrome P450 3A5enzyme
Norethisterone	A synthetic second-generation progestin used for contraception, prevention of endometrial hyperplasia in hormone replacement therapy, and in the treatment of other hormone-mediated illnesses such as endometriosis.	Progesterone receptortarget ATP-dependent translocase ABCB1transporter Cytochrome P450 2C19enzyme Albumincarrier Sex hormone-binding globulincarrier Aldo-keto reductase family 1 member C4enzyme 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme 3-oxo-5-alpha-steroid 4-dehydrogenaseenzyme Aldo-keto reductase family 1 member D1enzyme Cytochrome P450 3A4enzyme Cytochrome P450 1A2enzyme Cytochrome P450 2A6enzyme Glucocorticoid receptortarget Androgen receptortarget
Relugolix	An oral GnRH receptor antagonist for androgen deprivation therapy in the treatment of advanced prostate cancer.	Albumincarrier Alpha-1-acid glycoprotein 1carrier ATP-dependent translocase ABCB1transporter Broad substrate specificity ATP-binding cassette transporter ABCG2transporter Cytochrome P450 3A Subfamilyenzyme Cytochrome P450 2C8enzyme Cytochrome P450 2B6enzyme Gonadotropin-releasing hormone receptortarget
Tranexamic acid	An antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders.	Plasminogentarget

Clinical Trials

Identifier	Title	Drug(s)	Purpose	Phase	Status
NCT05862805	PAI-1, tPA, TFPI and HEECs in Uterine Hemostasis	No drug interventions	other	1 / 2	recruiting
NCT05856838	NovaSure Study: Endometrial Ablation in Women With Heavy Menstrual Bleeding	No drug interventions	treatment	Not Available	recruiting
NCT06064851	Delivering Transcutaneous Auricular Neurostimulation to Reduce Heavy Menstrual Bleeding in Von Willebrand Disease Patients	No drug interventions	treatment	Not Available	recruiting
NCT03412890	LIBERTY EXTENSION: Efficacy and Safety Extension Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids	Estradiol Norethisterone Relugolix	treatment	3	completed
NCT03070951	Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids	Linzagolix	treatment	3	completed
NCT04425577	Ultrasound Evaluation Versus Direct Measurement of Uterine Cavity Length	No drug interventions	diagnostic	Not Available	completed
NCT01846507	Tranexamic Acid in Adolescents With Heavy Menstrual Bleeding	Tranexamic acid	treatment	4	completed
NCT05079815	Heavy Menstrual Bleeding and Iron Deficiency Anemia	No drug interventions	Not Available	Not Available	not_yet_recruiting
NCT04477837	Prospective Comparison of Incidence of Heavy Menstrual Bleeding in Women Treated With Direct Oral Anticoagulants	Apixaban Dabigatran Edoxaban Rivaroxaban	Not Available	Not Available	completed
NCT01391052	Pretreatment With Norethindrone Acetate Prior to Levonorgestrel IUS Insertion for Heavy Menstrual Bleeding	Norethisterone	treatment	4	unknown_status
NCT03725306	Librata Endometrial Ablation Device Treatment to Reduce Menstrual Blood Loss	No drug interventions	treatment	3	unknown_status
NCT02001324	HMB- Data Collection Methods	No drug interventions	other	Not Available	terminated
NCT05176496	A Study Called Champion-HMB to Learn More About Females With Heavy Menstrual Bleeding and Available Treatments to Enable Earlier Diagnosis and to Predict Courses of Treatment	No drug interventions	Not Available	Not Available	completed
NCT03049735	LIBERTY 1: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids	Estradiol Norethisterone Relugolix	treatment	3	completed
NCT06122363	Impact of Incomplete Endometrial Ablation	No drug interventions	Not Available	Not Available	enrolling_by_invitation
NCT03186586	Ulipristal Versus Placebo for Women With Bleeding Induced by Mirena	Ulipristal	treatment	4	unknown_status
NCT05922657	A Registry to Gather Real World Use Data on the Cerene® Cryotherapy Device	No drug interventions	Not Available	Not Available	recruiting
NCT01431326	Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care	Alfentanil Amikacin Aminocaproic acid Bosentan Cefepime Cidofovir Ciprofloxacin Clozapine Fosfomycin Haloperidol Labetalol Lurasidone Methylprednisolone Molindone Nafcillin Nifedipine Oxycodone Pentobarbital Piperacillin Rocuronium Sevelamer Spironolactone Tazobactam Tobramycin Tranexamic acid Vancomycin Vecuronium Warfarin Ziprasidone Zolpidem	Not Available	Not Available	completed
NCT03027973	Quality of Life Outcomes for Ulipristal Acetate and Tranexamic Acid in the Management of Heavy Menstrual Bleeding	Tranexamic acid Ulipristal	treatment	1	withdrawn
NCT05406960	Therapeutic Effect of Herbal Infusion on Menometrorrhagia	No drug interventions	treatment	Not Available	completed
NCT02691494	Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women (Replicate Study)	Elagolix Estradiol Norethisterone	treatment	3	completed
NCT02971189	Librata Endometrial Ablation Device Treatment to Reduce Menstrual Blood Loss in Sites Across the United Kingdom	No drug interventions	treatment	Not Available	unknown_status
NCT03271489	Long-Term Safety Study of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women	Elagolix	treatment	3	completed
NCT04778072	A Clinical Study on Adherence and Efficacy of Different Doses of Active Iron in Treatment Resistant Subjects	No drug interventions	treatment	Not Available	unknown_status
NCT05916469	Heavy Menstrual Bleeding Progestin Treatment in Bleeding Disorders Study	Levonorgestrel Norethisterone	Not Available	Not Available	not_yet_recruiting
NCT05606146	IUB SEAD RED (Revolutionary Endometrial Ablation Device Study)	No drug interventions	treatment	Not Available	recruiting
NCT02943655	Treatment of Heavy and/or Prolonged Menstrual Bleeding Without Organic Cause	Medroxyprogesterone acetate Mefenamic acid	treatment	3	completed
NCT00386308	Efficacy and Safety Study of XP12B in Women With Menorrhagia	Tranexamic acid XP12B	treatment	3	completed
NCT01695902	Therapeutic Equivalence Trial of Two Hormonal-IUDs in Patients With Heavy Menstrual Bleeding	Levonorgestrel	treatment	3	completed
NCT05026502	A Study to Assess Patient-Reported Quality of Life and Effectiveness on Control of Bleeding in Adult Participants With Heavy Menstrual Bleeding Due to Uterine Fibroids Taking Oral Oriahnn Capsules	No drug interventions	Not Available	Not Available	terminated
NCT03103087	LIBERTY 2: Efficacy & Safety Study of Relugolix in Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids	Estradiol Norethisterone Relugolix	treatment	3	completed
NCT02654054	Efficacy and Safety of Elagolix in Combination With Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding Associated With Uterine Fibroids in Premenopausal Women	Elagolix Estradiol Norethisterone	treatment	3	completed
NCT03368898	Quality of Life in Premenopausal Women With Heavy Menstrual Bleeding	No drug interventions	Not Available	Not Available	completed
NCT00401193	Efficacy and Safety of XP12B in Women With Menorrhagia	Tranexamic acid XP12B	treatment	3	completed
NCT06452342	TRanEXamic Acid to Decrease Heavy Menstrual Bleeding in Individuals Anticoagulated for Venous Thromboembolism Pilot Study	Tranexamic acid	treatment	4	not_yet_recruiting
NCT05007899	Alternate Day Versus Daily Oral Iron Therapy in Adolescents	Ferrous sulfate anhydrous Iron Dextran	other	4	completed
NCT05685199	Identifying the Determinants of Bleeding and Hypermobility in Patients With Heavy Menstrual Bleeding	No drug interventions	Not Available	Not Available	recruiting
NCT03070899	Efficacy and Safety of OBE2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids	Linzagolix	treatment	3	completed
NCT04856306	Myomectomy vs Uterine Artery Embolization vs GnRh Antagonist for AUB-L	Elagolix Estradiol Norethisterone	Not Available	Not Available	active_not_recruiting
NCT04132349	Ulipristal Acetate in Symptomatic Uterine Fibroid	Ulipristal	treatment	4	terminated
NCT04959396	IUB SEAD RED (Revolutionary Endometrial Ablation Device Study	No drug interventions	treatment	Not Available	recruiting
NCT04205266	IV Iron vs Oral Iron for Treatment of Anemia in Women With Abnormal Uterine Bleeding	Ferrous sulfate anhydrous Ferumoxytol Iron	treatment	4	recruiting
NCT01769820	Dexamethasone for Excessive Menstruation	Dexamethasone	treatment	2	completed
NCT02925494	An Extension Study to Evaluate the Efficacy and Safety of Elagolix in Premenopausal Women With Heavy Menstrual Bleeding Associated With Uterine Fibroids	Elagolix Estradiol Norethisterone	treatment	3	completed
NCT04267562	Minitouch Endometrial Ablation System Treatment for Menorrhagia: An Evaluation of Safety & Effectiveness	No drug interventions	treatment	Not Available	active_not_recruiting
NCT02934789	Effectiveness of Truclear on Patient Quality of Life	Levonorgestrel	treatment	Not Available	completed
NCT02449304	Evaluation of 4th Generation Bipolar Radiofrequency Endometrial Ablation Device	No drug interventions	treatment	4	unknown_status
NCT00113568	Safety Study of XP12B in Women With Menorrhagia	Tranexamic acid XP12B	treatment	3	completed
NCT03317795	Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids	Levonorgestrel Tranexamic acid	treatment	4	completed
NCT05620355	Efficacy and Safety of BG2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine Fibroids.	No drug interventions	treatment	3	recruiting