Midazolam hydrochlorideProduct ingredient for Midazolam
- Name
- Midazolam hydrochloride
- Drug Entry
- Midazolam
Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties.6 It belongs to a class of drugs called benzodiazepines. This drug is unique from others in this class due to its rapid onset of effects and short duration of action.6 Midazolam is available by oral, rectal, intranasal, intramuscular (IM), and intravenous (IV) routes and has been used in various biomedical applications, including dentistry, cardiac surgery, and endoscopic procedures as pre-anesthetic medication, and as an adjunct to local anesthesia.21
This drug was initially approved by the US FDA in 1985, and has been approved for various indications since.19 In late 2018, the intramuscular preparation was approved by the FDA for the treatment of status epilepticus in adults.19 In May 2019, the nasal spray of midazolam was approved for the acute treatment of distinctive intermittent, stereotypic seizure episodes in patients 12 years of age and older.8 Midazolam is considered a schedule IV drug in the United States due to the low potential for abuse and low risk of dependence.10
- Accession Number
- DBSALT000118
- Structure
Structure for Midazolam hydrochloride (DBSALT000118)
- Synonyms
- Not Available
- UNII
- W7TTW573JJ
- CAS Number
- 59467-96-8
- Weight
- Average: 362.228
Monoisotopic: 361.054881082 - Chemical Formula
- C18H14Cl2FN3
- InChI Key
- PLYSCVSCYOQVRP-UHFFFAOYSA-N
- InChI
- InChI=1S/C18H13ClFN3.ClH/c1-11-21-9-13-10-22-18(14-4-2-3-5-16(14)20)15-8-12(19)6-7-17(15)23(11)13;/h2-9H,10H2,1H3;1H
- IUPAC Name
- 12-chloro-9-(2-fluorophenyl)-3-methyl-2,4,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),3,5,8,11,13-hexaene hydrochloride
- SMILES
- Cl.CC1=NC=C2CN=C(C3=CC=CC=C3F)C3=C(C=CC(Cl)=C3)N12
- External Links
- PubChem Compound
- 43032
- ChemSpider
- 39217
- ChEBI
- 6932
- ChEMBL
- CHEMBL1200420
- Wikipedia
- Midazolam
- Predicted Properties
Property Value Source Water Solubility 0.00987 mg/mL ALOGPS logP 3.89 ALOGPS logP 3.97 Chemaxon logS -4.5 ALOGPS pKa (Strongest Basic) 6.19 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 30.18 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 99.43 m3·mol-1 Chemaxon Polarizability 32.71 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon