Cyclizine hydrochlorideProduct ingredient for Cyclizine
- Name
- Cyclizine hydrochloride
- Drug Entry
- Cyclizine
A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)
- Accession Number
- DBSALT000399 (DBSALT001535)
- Structure
Structure for Cyclizine hydrochloride (DBSALT000399)
- Synonyms
- Cyclizin dihydrochlorid / Cyclizine chloride / Cyclizine HCl
- UNII
- W0O1NHP4WE
- CAS Number
- 303-25-3
- Weight
- Average: 302.842
Monoisotopic: 302.154976453 - Chemical Formula
- C18H23ClN2
- InChI Key
- UKPBEPCQTDRZSE-UHFFFAOYSA-N
- InChI
- InChI=1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H
- IUPAC Name
- 1-(diphenylmethyl)-4-methylpiperazine hydrochloride
- SMILES
- Cl.CN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1
- External Links
- PubChem Compound
- 517299
- ChemSpider
- 451325
- ChEBI
- 51045
- ChEMBL
- CHEMBL1324714
- Predicted Properties
Property Value Source Water Solubility 0.0752 mg/mL ALOGPS logP 3.55 ALOGPS logP 3.55 Chemaxon logS -3.6 ALOGPS pKa (Strongest Basic) 8.2 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 6.48 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 84.93 m3·mol-1 Chemaxon Polarizability 31.15 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon