Trihexyphenidyl hydrochlorideProduct ingredient for Trihexyphenidyl
- Name
- Trihexyphenidyl hydrochloride
- Drug Entry
- Trihexyphenidyl
Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.11,12 Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity.9 Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is not a first line treatment due to significant adverse effects.15 It has largely been replaced by drugs such as levodopa.15
Trihexyphenidyl was granted FDA approval on 13 May 1949.10
- Accession Number
- DBSALT000448
- Structure
- Synonyms
- Trihexyphenidyl HCl
- UNII
- AO61G82577
- CAS Number
- 52-49-3
- Weight
- Average: 337.927
Monoisotopic: 337.217242358 - Chemical Formula
- C20H32ClNO
- InChI Key
- QDWJJTJNXAKQKD-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H31NO.ClH/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21;/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2;1H
- IUPAC Name
- 1-cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride
- SMILES
- Cl.OC(CCN1CCCCC1)(C1CCCCC1)C1=CC=CC=C1
- External Links
- PubChem Compound
- 66007
- ChemSpider
- 59399
- ChEBI
- 9721
- ChEMBL
- CHEMBL1092
- Wikipedia
- Trihexyphenidyl
- Predicted Properties
Property Value Source Water Solubility 0.00314 mg/mL ALOGPS logP 4.93 ALOGPS logP 4.23 Chemaxon logS -5 ALOGPS pKa (Strongest Acidic) 13.84 Chemaxon pKa (Strongest Basic) 9.32 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 23.47 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 93.21 m3·mol-1 Chemaxon Polarizability 36.69 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon