Nicardipine HydrochlorideProduct ingredient for Nicardipine
- Name
- Nicardipine Hydrochloride
- Drug Entry
- Nicardipine
A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
- Accession Number
- DBSALT000499
- Structure
Structure for Nicardipine Hydrochloride (DBSALT000499)
- Synonyms
- Nicardipine HCl
- UNII
- K5BC5011K3
- CAS Number
- 54527-84-3
- Weight
- Average: 515.986
Monoisotopic: 515.182313414 - Chemical Formula
- C26H30ClN3O6
- InChI Key
- AIKVCUNQWYTVTO-UHFFFAOYSA-N
- InChI
- InChI=1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H
- IUPAC Name
- 3-{2-[benzyl(methyl)amino]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
- SMILES
- Cl.COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)N(=O)=O)C(=O)OCCN(C)CC1=CC=CC=C1
- External Links
- PubChem Compound
- 41114
- ChemSpider
- 37526
- ChEBI
- 7551
- ChEMBL
- CHEMBL1200326
- Predicted Properties
Property Value Source Water Solubility 0.00247 mg/mL ALOGPS logP 4.34 ALOGPS logP 3.56 Chemaxon logS -5.3 ALOGPS pKa (Strongest Acidic) 16.97 Chemaxon pKa (Strongest Basic) 8.1 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 113.69 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 134.8 m3·mol-1 Chemaxon Polarizability 50.5 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon