Meclizine hydrochlorideProduct ingredient for Meclizine
- Name
- Meclizine hydrochloride
- Drug Entry
- Meclizine
Meclizine is a histamine H1 antagonist with antiemetic and antivertigo properties. It is used in the symptomatic treatment of motion sickness and control of vertigo associated with vestibular system diseases. It also exhibits anticholinergic, central nervous system depressant, and local anesthetic effects.4 Commonly marketed under the brand name Antivert in the U.S., meclizine is available as oral tablets.
- Accession Number
- DBSALT000678
- Structure
Structure for Meclizine hydrochloride (DBSALT000678)
- Synonyms
- Meclizine HCl
- UNII
- HDP7W44CIO
- CAS Number
- 31884-77-2
- Weight
- Average: 445.424
Monoisotopic: 444.173519006 - Chemical Formula
- C25H30Cl2N2O
- InChI Key
- BAAVORPTHSKWGJ-UHFFFAOYSA-N
- InChI
- InChI=1S/C25H27ClN2.ClH.H2O/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;1H;1H2
- IUPAC Name
- 1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine hydrate hydrochloride
- SMILES
- O.Cl.CC1=CC(CN2CCN(CC2)C(C2=CC=CC=C2)C2=CC=C(Cl)C=C2)=CC=C1
- External Links
- PubChem Compound
- 49800000
- ChemSpider
- 25043461
- ChEBI
- 774541
- ChEMBL
- CHEMBL1200590
- Wikipedia
- Meclizine
- Predicted Properties
Property Value Source Water Solubility 0.00103 mg/mL ALOGPS logP 5.59 ALOGPS logP 6.39 Chemaxon logS -5.6 ALOGPS pKa (Strongest Basic) 7.71 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 6.48 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 119.39 m3·mol-1 Chemaxon Polarizability 44.46 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon