Piperazine citrateProduct ingredient for Piperazine
- Name
- Piperazine citrate
- Drug Entry
- Piperazine
Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.
- Accession Number
- DBSALT000775
- Structure
Structure for Piperazine citrate (DBSALT000775)
- Synonyms
- Not Available
- UNII
- 63KP7FXF2I
- CAS Number
- 41372-10-5
- Weight
- Average: 278.2591
Monoisotopic: 278.11140094 - Chemical Formula
- C10H18N2O7
- InChI Key
- SWDXALWLRYIJHK-UHFFFAOYSA-N
- InChI
- InChI=1S/C6H8O7.C4H10N2/c7-3(8)1-6(13,5(11)12)2-4(9)10;1-2-6-4-3-5-1/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);5-6H,1-4H2
- IUPAC Name
- 2-hydroxypropane-1,2,3-tricarboxylic acid; piperazine
- SMILES
- C1CNCCN1.OC(=O)CC(O)(CC(O)=O)C(O)=O
- External Links
- PubChem Compound
- 114763
- ChemSpider
- 102744
- ChEBI
- 774793
- ChEMBL
- CHEMBL1200842
- Wikipedia
- Piperazine
- Predicted Properties
Property Value Source Water Solubility 106.0 mg/mL ALOGPS logP -1.3 ALOGPS logP -1.3 Chemaxon logS -0.26 ALOGPS pKa (Strongest Acidic) 3.05 Chemaxon pKa (Strongest Basic) -4.2 Chemaxon Physiological Charge -3 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 132.13 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 35.62 m3·mol-1 Chemaxon Polarizability 15.5 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon