Lomefloxacin hydrochlorideProduct ingredient for Lomefloxacin

Name
Lomefloxacin hydrochloride
Drug Entry
Lomefloxacin

Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.

Accession Number
DBSALT000795
Structure
Synonyms
Lomefloxacin HCl
UNII
9VC7S3ZXXB
CAS Number
98079-52-8
Weight
Average: 387.809
Monoisotopic: 387.116125638
Chemical Formula
C17H20ClF2N3O3
InChI Key
KXEBLAPZMOQCKO-UHFFFAOYSA-N
InChI
InChI=1S/C17H19F2N3O3.ClH/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22;/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25);1H
IUPAC Name
1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride
SMILES
Cl.CCN1C=C(C(O)=O)C(=O)C2=CC(F)=C(N3CCNC(C)C3)C(F)=C12
KEGG Compound
C08053
PubChem Compound
68624
ChemSpider
61883
ChEBI
6518
ChEMBL
CHEMBL1728
Wikipedia
Lomefloxacin
Predicted Properties
PropertyValueSource
Water Solubility0.106 mg/mLALOGPS
logP0ALOGPS
logP-0.43Chemaxon
logS-3.5ALOGPS
pKa (Strongest Acidic)5.45Chemaxon
pKa (Strongest Basic)8.78Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area72.88 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity90.11 m3·mol-1Chemaxon
Polarizability34.56 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon