Pirenzepine hydrochlorideProduct ingredient for Pirenzepine
- Name
- Pirenzepine hydrochloride
- Drug Entry
- Pirenzepine
An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as cimetidine and ranitidine. It is generally well tolerated by patients.
- Accession Number
- DBSALT001002
- Structure
Structure for Pirenzepine hydrochloride (DBSALT001002)
- Synonyms
- Pirenzepine HCl
- UNII
- 10YM403FLS
- CAS Number
- 29868-97-1
- Weight
- Average: 424.33
Monoisotopic: 423.1228804 - Chemical Formula
- C19H23Cl2N5O2
- InChI Key
- FFNMBRCFFADNAO-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H21N5O2.2ClH/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);2*1H
- IUPAC Name
- 2-[2-(4-methylpiperazin-1-yl)acetyl]-2,4,9-triazatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-10-one dihydrochloride
- SMILES
- Cl.Cl.CN1CCN(CC(=O)N2C3=CC=CC=C3C(=O)NC3=C2N=CC=C3)CC1
- External Links
- ChemSpider
- 64497
- ChEBI
- 32014
- ChEMBL
- CHEMBL1531864
- Predicted Properties
Property Value Source Water Solubility 0.682 mg/mL ALOGPS logP 1.26 ALOGPS logP 0.97 Chemaxon logS -2.7 ALOGPS pKa (Strongest Acidic) 12.02 Chemaxon pKa (Strongest Basic) 7.2 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 68.78 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 100.93 m3·mol-1 Chemaxon Polarizability 36.76 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon