Zolpidem tartrateProduct ingredient for Zolpidem
- Name
- Zolpidem tartrate
- Drug Entry
- Zolpidem
Zolpidem, also known as Ambien, is a hypnotic drug that was initially approved by the FDA in 1992 Label. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of sleep, and decreases the number of awakenings during sleep in patients with temporary (transient) insomnia. It is available in both immediate acting and extended release forms Label, 18.
Its tolerability profile is favorable when administered according to the manufacturer’s instructions, with a low risk of drug withdrawal, drug dependence, and drug tolerance 6. In addition, zolpidem improves sleep quality in patients suffering from chronic insomnia and can show mild muscle relaxant properties 15. Research also shows that zolpidem is rapid and effective in restoring brain function for patients in a vegetative state following brain injury. This drug has the propensity to completely or partially reverse the abnormal metabolism of damaged brain cells after injury 15, 9.
- Accession Number
- DBSALT001047
- Structure
Structure for Zolpidem tartrate (DBSALT001047)
- Synonyms
- N,N,6-Trimethyl-2-p-tolylimidazo(1,2-a)pyridine-3-acetamide L-(+)-tartrate (2:1) / Zolpidem hemitartrate / Zolpidem L-(+)-hemitartrate
- External IDs
- SL 80.0750-23N / SL-80.0750 / SL-80.0750-23N
- UNII
- WY6W63843K
- CAS Number
- 99294-93-6
- Weight
- Average: 764.88
Monoisotopic: 764.35336253 - Chemical Formula
- C42H48N6O8
- InChI Key
- VXRDAMSNTXUHFX-CEAXSRTFSA-N
- InChI
- InChI=1S/2C19H21N3O.C4H6O6/c2*1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19;5-1(3(7)8)2(6)4(9)10/h2*5-10,12H,11H2,1-4H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1
- IUPAC Name
- (2R,3R)-2,3-dihydroxybutanedioic acid; bis(N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide)
- SMILES
- O[C@H]([C@@H](O)C(O)=O)C(O)=O.CN(C)C(=O)CC1=C(N=C2C=CC(C)=CN12)C1=CC=C(C)C=C1.CN(C)C(=O)CC1=C(N=C2C=CC(C)=CN12)C1=CC=C(C)C=C1
- External Links
- KEGG Drug
- D00706
- ChemSpider
- 390093
- ChEBI
- 10126
- ChEMBL
- CHEMBL1723343
- Wikipedia
- Zolpidem
- Predicted Properties
Property Value Source Water Solubility 0.0313 mg/mL ALOGPS logP 3.15 ALOGPS logP 3.02 Chemaxon logS -4 ALOGPS pKa (Strongest Basic) 5.65 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 37.61 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 93.58 m3·mol-1 Chemaxon Polarizability 35.19 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon