Nalorphine hydrochlorideProduct ingredient for Nalorphine
- Name
- Nalorphine hydrochloride
- Drug Entry
- Nalorphine
Nalorphine is a mixed opioid agonist–antagonist. It acts at two opioid receptors—at the mu receptor it has antagonistic effects, and at the kappa receptors it exerts high-efficacy agonistic characteristics. It is used to reverse opioid overdose and (starting in the 1950s) in a challenge test to determine opioid dependence.
- Accession Number
- DBSALT001652
- Structure
Structure for Nalorphine hydrochloride (DBSALT001652)
- Synonyms
- Nalorphine HCl
- UNII
- 9FPE56Z2TW
- CAS Number
- 57-29-4
- Weight
- Average: 347.84
Monoisotopic: 347.1288213 - Chemical Formula
- C19H22ClNO3
- InChI Key
- NAHATSPWSULUAA-ZQGPYOJVSA-N
- InChI
- InChI=1S/C19H21NO3.ClH/c1-2-8-20-9-7-19-12-4-6-15(22)18(19)23-17-14(21)5-3-11(16(17)19)10-13(12)20;/h2-6,12-13,15,18,21-22H,1,7-10H2;1H/t12-,13+,15-,18-,19-;/m0./s1
- IUPAC Name
- (1S,5R,13R,14S,17R)-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,15-tetraene-10,14-diol hydrochloride
- SMILES
- Cl.[H][C@@]12OC3=C(O)C=CC4=C3[C@@]11CCN(CC=C)[C@]([H])(C4)[C@]1([H])C=C[C@@H]2O
- External Links
- ChemSpider
- 4588488
- ChEMBL
- CHEMBL1908349
- Predicted Properties
Property Value Source Water Solubility 1.36 mg/mL ALOGPS logP 1.55 ALOGPS logP 1.68 Chemaxon logS -2.4 ALOGPS pKa (Strongest Acidic) 10.2 Chemaxon pKa (Strongest Basic) 8.81 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 52.93 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 89.29 m3·mol-1 Chemaxon Polarizability 33.26 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon