Macular Edema

Also known as: Edema Macular / Macular Oedema / Macular Edema (ME) / Macular retinal edema (disorder)

Drug	Drug Name	Drug Description
DB08885	Aflibercept	A vascular endothelial growth factor (VEGF) inhibitor used to treat Neovascular (Wet) Age-Related Macular Degeneration (AMD), various types of macular edema and diabetic retinopathy, and metastatic colorectal cancer
DB01234	Dexamethasone	A glucocorticoid available in various modes of administration that is used for the treatment of various inflammatory conditions, including bronchial asthma, as well as endocrine and rheumatic disorders.
DB01270	Ranibizumab	A recombinant humanized monoclonal antibody and VEGF-A antagonist used for the management of macular edema after retinal vein occlusion, age-related macular degeneration (wet), and diabetic macular edema.
DB00620	Triamcinolone	A glucocorticoid used to treat a wide variety of inflammatory conditions of organ systems and tissues.

Drug	Drug Name	Target	Type
DB08885	Aflibercept	Vascular endothelial growth factor A	target
DB08885	Aflibercept	Placenta growth factor	target
DB08885	Aflibercept	Vascular endothelial growth factor B	target
DB01234	Dexamethasone	Glucocorticoid receptor	target
DB01234	Dexamethasone	Annexin A1	target
DB01234	Dexamethasone	Nitric oxide synthase, inducible	target
DB01234	Dexamethasone	Nuclear receptor subfamily 0 group B member 1	target
DB01234	Dexamethasone	Cytochrome P450 3A4	enzyme
DB01234	Dexamethasone	Cytochrome P450 3A5	enzyme
DB01234	Dexamethasone	Cytochrome P450 3A7	enzyme
DB01234	Dexamethasone	Bile salt export pump	transporter
DB01234	Dexamethasone	P-glycoprotein 1	transporter
DB01234	Dexamethasone	Canalicular multispecific organic anion transporter 1	transporter
DB01234	Dexamethasone	Solute carrier organic anion transporter family member 1A2	transporter
DB01234	Dexamethasone	ATP-binding cassette sub-family G member 2	transporter
DB01234	Dexamethasone	Steroid 17-alpha-hydroxylase/17,20 lyase	enzyme
DB01234	Dexamethasone	Cytochrome P450 1A1	enzyme
DB01234	Dexamethasone	Cytochrome P450 2A6	enzyme
DB01234	Dexamethasone	Cytochrome P450 2B6	enzyme
DB01234	Dexamethasone	Cytochrome P450 2C19	enzyme
DB01234	Dexamethasone	Cytochrome P450 2C8	enzyme
DB01234	Dexamethasone	Cytochrome P450 2E1	enzyme
DB01234	Dexamethasone	Cytochrome P450 3A43	enzyme
DB01234	Dexamethasone	Cytochrome P450 4A11	enzyme
DB01234	Dexamethasone	Nuclear receptor subfamily 1 group I member 2	target
DB01234	Dexamethasone	Cytochrome P450 11B1, mitochondrial	enzyme
DB01234	Dexamethasone	Serum albumin	carrier
DB01234	Dexamethasone	Corticosteroid 11-beta-dehydrogenase isozyme 2	enzyme
DB01234	Dexamethasone	Corticosteroid 11-beta-dehydrogenase isozyme 1	enzyme
DB01234	Dexamethasone	Solute carrier family 22 member 8	transporter
DB01270	Ranibizumab	Vascular endothelial growth factor A	target
DB00620	Triamcinolone	Corticosteroid-binding globulin	carrier
DB00620	Triamcinolone	Glucocorticoid receptor	target
DB00620	Triamcinolone	Cytochrome P450 3A4	enzyme
DB00620	Triamcinolone	Prostaglandin G/H synthase 2	enzyme
DB00620	Triamcinolone	Cholinesterase	enzyme
DB00620	Triamcinolone	Cytochrome P450 3A5	enzyme
DB00620	Triamcinolone	Cytochrome P450 3A7	enzyme
DB00620	Triamcinolone	Serum albumin	carrier

Drug	Drug Name	Phase	Status	Count
DB08885	Aflibercept	1	Completed	1
DB08885	Aflibercept	1	Unknown Status	1
DB01234	Dexamethasone	1	Active Not Recruiting	1
DB05311	Ecallantide	1	Terminated	1
DB00095	Efalizumab	1	Completed	1
DB16033	GSK2798745	1	Completed	1
DB00163	Vitamin E	1	Completed	2
DB01234	Dexamethasone	1 / 2	Completed	2
DB01234	Dexamethasone	1 / 2	Terminated	1
DB01270	Ranibizumab	1 / 2	Completed	3
DB06461	Squalamine	1 / 2	Completed	1
DB12258	Abicipar Pegol	2	Completed	1
DB00819	Acetazolamide	2	Active Not Recruiting	1
DB00819	Acetazolamide	2	Completed	1
DB08885	Aflibercept	2	Completed	1
DB08885	Aflibercept	2	Recruiting	1
DB08885	Aflibercept	2	Unknown Status	1
DB00112	Bevacizumab	2	Active Not Recruiting	1
DB00112	Bevacizumab	2	Completed	3
DB00112	Bevacizumab	2	Terminated	1
DB00112	Bevacizumab	2	Unknown Status	1
DB00484	Brimonidine	2	Completed	1
DB01234	Dexamethasone	2	Completed	5
DB01234	Dexamethasone	2	Terminated	1
DB00898	Ethanol	2	Completed	1
DB00591	Fluocinolone acetonide	2	Terminated	1
DB00465	Ketorolac	2	Completed	3
DB06802	Nepafenac	2	Completed	2
DB06802	Nepafenac	2	Unknown Status	1
DB11077	Polyethylene glycol 400	2	Completed	1
DB15566	Prednisolone acetate	2	Completed	1
DB11078	Propylene glycol	2	Completed	1
DB01270	Ranibizumab	2	Completed	6
DB01270	Ranibizumab	2	Terminated	1
DB01270	Ranibizumab	2	Unknown Status	2
DB01270	Ranibizumab	2	Withdrawn	1
DB00620	Triamcinolone	2	Terminated	1
DB00620	Triamcinolone	2	Withdrawn	1
DB00460	Verteporfin	2	Completed	1
DB00112	Bevacizumab	2 / 3	Unknown Status	1
DB12460	Conbercept	2 / 3	Terminated	1
DB01234	Dexamethasone	2 / 3	Completed	1
DB08885	Aflibercept	3	Completed	7
DB08885	Aflibercept	3	Terminated	1
DB00112	Bevacizumab	3	Completed	2
DB00112	Bevacizumab	3	Terminated	1
DB14864	Brolucizumab	3	Recruiting	1
DB00963	Bromfenac	3	Recruiting	1
DB12460	Conbercept	3	Completed	2
DB01234	Dexamethasone	3	Completed	9
DB01234	Dexamethasone	3	Recruiting	1
DB15303	Faricimab	3	Completed	2
DB14999	Human interferon beta	3	Completed	1
DB00465	Ketorolac	3	Recruiting	1
DB00563	Methotrexate	3	Completed	2
DB04895	Pegaptanib	3	Completed	1
DB00388	Phenylephrine	3	Recruiting	1
DB01270	Ranibizumab	3	Completed	13
DB01270	Ranibizumab	3	Recruiting	1
DB01270	Ranibizumab	3	Terminated	2
DB00620	Triamcinolone	3	Completed	4
DB00620	Triamcinolone	3	Recruiting	1
DB00620	Triamcinolone	3	Terminated	2
DB08885	Aflibercept	4	Completed	3
DB08885	Aflibercept	4	Recruiting	1
DB00112	Bevacizumab	4	Completed	1
DB00112	Bevacizumab	4	Recruiting	1
DB00112	Bevacizumab	4	Unknown Status	2
DB01234	Dexamethasone	4	Completed	4
DB01234	Dexamethasone	4	Unknown Status	2
DB06781	Difluprednate	4	Terminated	1
DB00328	Indomethacin	4	Completed	1
DB00465	Ketorolac	4	Completed	1
DB00563	Methotrexate	4	Terminated	1
DB06802	Nepafenac	4	Completed	1
DB06802	Nepafenac	4	Terminated	1
DB11133	Omega-3 fatty acids	4	Completed	1
DB13514	Pranoprofen	4	Completed	1
DB15566	Prednisolone acetate	4	Terminated	1
DB01270	Ranibizumab	4	Completed	5
DB01270	Ranibizumab	4	Recruiting	1
DB01270	Ranibizumab	4	Terminated	1
DB01270	Ranibizumab	4	Unknown Status	1
DB00620	Triamcinolone	4	Unknown Status	1
DB08885	Aflibercept	Not Available	Completed	5
DB00112	Bevacizumab	Not Available	Completed	4
DB00112	Bevacizumab	Not Available	Unknown Status	1
DB12460	Conbercept	Not Available	Unknown Status	1
DB01234	Dexamethasone	Not Available	Completed	12
DB01234	Dexamethasone	Not Available	Terminated	4
DB01234	Dexamethasone	Not Available	Unknown Status	2
DB00586	Diclofenac	Not Available	Completed	2
DB00465	Ketorolac	Not Available	Completed	1
DB01270	Ranibizumab	Not Available	Completed	5
DB01270	Ranibizumab	Not Available	Recruiting	1
DB01270	Ranibizumab	Not Available	Unknown Status	3
DB01270	Ranibizumab	Not Available	Withdrawn	1
DB00620	Triamcinolone	Not Available	Completed	2
DB00620	Triamcinolone	Not Available	Recruiting	1