Sialorrhea

Also known as: Sialorrhea (Excessive Drooling) / Disturbances of salivary secretion / Saliva secretion increased / Saliva increased / Increased salivation / Sialorrhoea / Hypersalivation / Excessive salivation (disorder) / Saliva secretion excessive / Salivary hypersecretion / Ptyalism

Drug	Drug Name	Drug Description
DB00083	Botulinum toxin type A	A purified form of botulinum toxin type A used to block acetylcholine release in the treatment of chronic sialorrhea, muscle spasticity, and dystonia, as well as in cosmetic applications.
DB00986	Glycopyrronium	An anticholinergic agent used to treat hyperhidrosis, severe drooling, COPD, used with other medications to treat ulcers, and used in anesthesia.

Drug	Drug Name	Target	Type
DB00083	Botulinum toxin type A	Synaptosomal-associated protein 25	target
DB00083	Botulinum toxin type A	Rho-related GTP-binding protein RhoB	target
DB00083	Botulinum toxin type A	Serum albumin	carrier
DB00986	Glycopyrronium	Muscarinic acetylcholine receptor M1	target
DB00986	Glycopyrronium	Muscarinic acetylcholine receptor M3	target
DB00986	Glycopyrronium	Muscarinic acetylcholine receptor M2	target
DB00986	Glycopyrronium	Cytochrome P450 2D6	enzyme
DB00986	Glycopyrronium	Cytochrome P450 1A2	enzyme
DB00986	Glycopyrronium	Cytochrome P450 2B6	enzyme
DB00986	Glycopyrronium	Cytochrome P450 2C9	enzyme
DB00986	Glycopyrronium	Cytochrome P450 2C18	enzyme
DB00986	Glycopyrronium	Cytochrome P450 2C19	enzyme
DB00986	Glycopyrronium	Cytochrome P450 3A4	enzyme
DB00986	Glycopyrronium	Solute carrier family 22 member 2	transporter
DB00986	Glycopyrronium	Multidrug and toxin extrusion protein 1	transporter
DB00986	Glycopyrronium	Muscarinic acetylcholine receptor M4	target
DB00986	Glycopyrronium	Muscarinic acetylcholine receptor M5	target
DB00986	Glycopyrronium	Serum albumin	carrier
DB00986	Glycopyrronium	alpha1-acid glycoprotein	carrier

Drug	Drug Name	Phase	Status	Count
DB00572	Atropine	0	Active Not Recruiting	1
DB00986	Glycopyrronium	1 / 2	Completed	1
DB00747	Scopolamine	1 / 2	Completed	1
DB00083	Botulinum toxin type A	2	Completed	2
DB00986	Glycopyrronium	2	Unknown Status	1
DB00332	Ipratropium	2	Unknown Status	1
DB00809	Tropicamide	2	Completed	1
DB00083	Botulinum toxin type A	2 / 3	Completed	1
DB00083	Botulinum toxin type A	2 / 3	Unknown Status	1
DB00042	Botulinum toxin type B	2 / 3	Completed	1
DB00042	Botulinum toxin type B	3	Completed	2
DB00042	Botulinum toxin type B	3	Not Yet Recruiting	1
DB00986	Glycopyrronium	3	Completed	1
DB00936	Salicylic acid	3	Completed	1
DB00986	Glycopyrronium	4	Recruiting	1
DB00572	Atropine	Not Available	Completed	1
DB00083	Botulinum toxin type A	Not Available	Completed	1
DB00363	Clozapine	Not Available	Completed	1
DB00986	Glycopyrronium	Not Available	Completed	1
DB00424	Hyoscyamine	Not Available	Completed	1
DB01221	Ketamine	Not Available	Completed	1
DB09153	Sodium chloride	Not Available	Completed	1