Cluster Headache

Also known as: Cluster headaches / Cluster headache / Headaches, Cluster / Ciliary neuralgia / Headache histamine / Horton's headache / Headache vasomotor / Migrainous neuralgia / Headaches cluster

DrugDrug NameDrug Description
DB00320DihydroergotamineAn ergot alkaloid used in the acute treatment of migraine headache and cluster headache.
DB00696ErgotamineAn alpha-1 selective adrenergic agonist vasoconstrictor used to treat migraines with or without aura and cluster headaches.
DB15790MecloxamineA medication indicated in combination with caffeine, ergotamine, and acetaminophen for the treatment of headaches and migraines.
DB00661VerapamilA non-dihydropyridine calcium channel blocker used in the treatment of angina, arrhythmia, and hypertension.
DB00315ZolmitriptanA member of the triptan class of 5-HT(1B/1D/1F) receptor agonist drugs used for the acute treatment of migraine with or without aura in adults.
DrugDrug NameTargetType
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Dtarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Btarget
DB00320DihydroergotamineCytochrome P450 3A4enzyme
DB00320DihydroergotamineAlpha-2A adrenergic receptortarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 2Btarget
DB00320DihydroergotamineP-glycoprotein 1transporter
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Atarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Etarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 2Atarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 2Ctarget
DB00320DihydroergotamineAlpha-1 adrenergic receptorstarget
DB00320DihydroergotamineAlpha-2 adrenergic receptorstarget
DB00320DihydroergotamineDopamine D2 receptortarget
DB00320DihydroergotamineDopamine D3 receptortarget
DB00320DihydroergotamineDopamine D4 receptortarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 1Ftarget
DB00320Dihydroergotamine5-hydroxytryptamine receptor 4target
DB00320DihydroergotamineBeta-3 adrenergic receptortarget
DB00696ErgotamineAlpha-1A adrenergic receptortarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Dtarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Btarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Atarget
DB00696ErgotamineAlpha-2A adrenergic receptortarget
DB00696ErgotamineDopamine D2 receptortarget
DB00696ErgotamineCytochrome P450 3A4enzyme
DB00696ErgotamineAlpha-1B adrenergic receptortarget
DB00696ErgotamineAlpha-1D adrenergic receptortarget
DB00696ErgotamineP-glycoprotein 1transporter
DB00696ErgotamineD(1) dopamine receptortarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Atarget
DB00696Ergotamine5-hydroxytryptamine receptor 1Ftarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Ctarget
DB00696Ergotamine5-hydroxytryptamine receptor 2Btarget
DB00696ErgotamineAlpha-2C adrenergic receptortarget
DB00661VerapamilATP-sensitive inward rectifier potassium channel 11target
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB00661VerapamilPotassium voltage-gated channel subfamily H member 2target
DB00661VerapamilVoltage-dependent L-type calcium channel subunit alpha-1Ctarget
DB00661VerapamilCytochrome P450 1A2enzyme
DB00661VerapamilCytochrome P450 3A5enzyme
DB00661VerapamilVoltage-dependent N-type calcium channel subunit alpha-1Btarget
DB00661VerapamilVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DB00661VerapamilSodium-dependent serotonin transportertarget
DB00661VerapamilCytochrome P450 3A4enzyme
DB00661VerapamilP-glycoprotein 1transporter
DB00661VerapamilSolute carrier family 22 member 1transporter
DB00661VerapamilCanalicular multispecific organic anion transporter 2transporter
DB00661VerapamilMultidrug resistance-associated protein 4transporter
DB00661VerapamilSolute carrier family 22 member 5transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1A2transporter
DB00661VerapamilMultidrug resistance-associated protein 7transporter
DB00661VerapamilSolute carrier family 22 member 4transporter
DB00661VerapamilSolute carrier organic anion transporter family member 1B1transporter
DB00661VerapamilCytochrome P450 2C8enzyme
DB00661VerapamilCytochrome P450 2C9enzyme
DB00661VerapamilCytochrome P450 2B6enzyme
DB00661VerapamilCytochrome P450 2C19enzyme
DB00661VerapamilCytochrome P450 2D6enzyme
DB00661VerapamilAlpha-1A adrenergic receptortarget
DB00661VerapamilAlpha-1B adrenergic receptortarget
DB00661VerapamilAlpha-1D adrenergic receptortarget
DB00661VerapamilSerum albumincarrier
DB00661VerapamilAlpha-1-acid glycoprotein 1carrier
DB00661VerapamilCytochrome P450 2C18enzyme
DB00661VerapamilCytochrome P450 2E1enzyme
DB00661VerapamilMultidrug resistance-associated protein 1transporter
DB00661VerapamilMultidrug and toxin extrusion protein 1transporter
DB00661VerapamilMultidrug and toxin extrusion protein 2transporter
DB00661VerapamilVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB00315Zolmitriptan5-hydroxytryptamine receptor 1Dtarget
DB00315Zolmitriptan5-hydroxytryptamine receptor 1Btarget
DB00315Zolmitriptan5-hydroxytryptamine receptor 1Ftarget
DB00315ZolmitriptanCytochrome P450 1A2enzyme
DB00315ZolmitriptanAmine oxidase [flavin-containing] Aenzyme
DB00315Zolmitriptan5-hydroxytryptamine receptor 1Atarget
DB00315ZolmitriptanP-glycoprotein 1transporter
DB00315Zolmitriptan5-hydroxytryptamine receptor 7target
DB00315Zolmitriptan5-hydroxytryptamine receptor 2Atarget
DB00315Zolmitriptan5-hydroxytryptamine receptor 2Btarget
DB00315Zolmitriptan5-hydroxytryptamine receptor 1Etarget
DrugDrug NamePhaseStatusCount
DB06774Capsaicin1Active Not Recruiting1
DB01234Dexamethasone1Withdrawn1
DB00465Ketorolac1Withdrawn1
DB09140Oxygen1Terminated1
DB11664Psilocybin1Active Not Recruiting1
DB00083Botulinum toxin type A1 / 2Completed2
DB01075Diphenhydramine1 / 2Completed1
DB01221Ketamine1 / 2Completed1
DB11664Psilocybin1 / 2Recruiting1
DB11842Angiotensin II2Completed1
DB00297Bupivacaine2Not Yet Recruiting1
DB00796Candesartan cilexetil2Completed1
DB09157Carbon dioxide2Terminated1
DB14039Erenumab2Not Yet Recruiting1
DB04829Lysergic acid diethylamide2Recruiting1
DB13003Cortivazol2 / 3Completed1
DB00661Verapamil2 / 3Completed1
DB00315Zolmitriptan2 / 3Completed1
DB00083Botulinum toxin type A3Recruiting1
DB14041Fremanezumab3Terminated1
DB09153Sodium chloride3Recruiting1
DB09072Sodium oxybate3Unknown Status1
DB11094Vitamin D3Recruiting1
DB00273Topiramate4Terminated1
DB00661Verapamil4Not Yet Recruiting1
DB00315Zolmitriptan4Unknown Status1
DB06379Calcitonin gene-related peptideNot AvailableUnknown Status1
DB00313Valproic acidNot AvailableCompleted1