Constipation

Also known as: Constipations / Constipation, unspecified / Constipation (& symptom)

DrugDrug NameDrug Description
DB09278Activated charcoalA gastric decontamination agent used in emergency clinical settings as a antidote to treat poisonings following excessive oral ingestion of certain medications or poisons.
DB09020BisacodylA stimulant laxative used for the temporary relief of occasional constipation and cleansing of the colon as a preparation for colonoscopy in adults.
DB14684Calcium polycarbophilA bulk forming laxative used to treat constipation.
DB11113Castor oilAn ingredient used in a variety of natural health products.
DB11089DocusateA medication used to treat constipation associated with dry, hard stools, or opioid induced constipation.
DB15478Frangula purshiana barkNot Annotated
DB09462GlycerinIt is used as a solvent, emollient, pharmaceutical agent, and sweetening agent.
DB12942LactitolAn orally administered osmotic laxative used to treat chronic idiopathic constipation.
DB00581LactuloseA disaccharide derivative of lactose used to treat constipation and portal systemic encephalopathy.
DB01046LubiprostoneA prostaglandin derivative used to treat constipation caused by irritable bowel syndrome and opioid-use.
DB09104Magnesium hydroxideAn inorganic compound used as a laxative and antacid.
DB00653Magnesium sulfateA drug used to treat convulsions during pregnancy, nephritis in children, magnesium deficiency, and tetany.
DB11228MethylcelluloseA compound used as a bulk forming laxative and is not an approved medication.
DB11057Mineral oilMineral oil is not considered an active pharmacological ingredient in pharmaceutical preparations and so has no official indication. It is typically present in topical formulations as an emollient and occlusive...
DB04824PhenolphthaleinA drug used for symptomatic relief of constipation and bowel cleansing prior to medical procedures.
DB09268Picosulfuric acidA stimulant laxative used for cleansing of the colon as a preparation for colonoscopy in adults.
DB14585Plantago ovata seedA plant extract indicated in the treatment of occasional constipation.
DB11097Plantago seedAn ingredient used in a variety of natural health products.
DB09287Polyethylene glycolA laxative used to treat constipation and used for bowel preparation before colonoscopies and other procedures.
DB11077Polyethylene glycol 400An ingredient used in a wide variety of medications, and is not an approved medication.
DB09125Potassium citrateAn agent used to manage renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.
DB00545PyridostigmineA cholinesterase inhibitor used for symptomatic treatment of myasthenia gravis and congenital myasthenic syndromes and to reverse neuromuscular blockade by nondepolarizing muscle relaxants.
DB10651RhubarbAn extract from Rhubarb used in allergy testing.
DB00140RiboflavinA vitamin used to correct vitamin B2 deficiency.
DB15889Senna leafA stimulant laxative indicated in the treatment of occasional constipation.
DB11365SennosidesA laxative used to treat constipation.
DB01390Sodium bicarbonateA compound used for the symptomatic treatment of heartburn, acid indigestion, and upset stomach as well as the treatment of metabolic acidosis associated with conditions such as severe renal disease and circulatory insufficiency due to shock.
DB13157Sodium lauryl sulfoacetateA laxative indicated in the treatment of constipation and bowel preparation for rectal endoscopy.
DB14502Sodium phosphate, dibasicAn osmotic laxative used to cleanse the colon before a colonoscopy.
DB09449Sodium phosphate, monobasicA source of phosphorus used prevent or correct hypophosphatemia in patients with restricted or no oral intake.
DB14503Sodium phosphate, monobasic, unspecified formAn osmotic laxative used to cleanse the colon before a colonoscopy.
DB01638SorbitolA product that can be used as a laxative to relieve constipation, and also as a urologic irrigating fluid. May also be used as a pharmaceutical sweetener.
DB16556SpermacetiA lubricant used in medications to treat constipation associated with hemorrhoids.
DB00391SulpirideA selective D2 dopamine receptor antagonist indicated to treat chronic and acute schizophrenia.
DrugDrug NameTargetType
DB09020BisacodylAquaporin-3target
DB09020BisacodylSodium/Potassium Transporting ATPase subunitstarget
DB11113Castor oilProstaglandin E2 receptor EP3 subtypetarget
DB11113Castor oilProstaglandin E2 receptor EP4 subtypetarget
DB09462GlycerinGroup IIE secretory phospholipase A2target
DB09462GlycerinInositol-3-phosphate synthase 1target
DB09462GlycerinAlcohol dehydrogenase 1Btarget
DB09462GlycerinInositol 1,4,5-trisphosphate receptor type 1target
DB09462GlycerinGlycodelintarget
DB09462GlycerinAlpha-N-acetylgalactosaminidasetarget
DB09462GlycerinADP-ribosylation factor 1target
DB09462GlycerinBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1target
DB09462GlycerinDNA mismatch repair protein MutLtarget
DB09462GlycerinRibonucleoside-diphosphate reductase 1 subunit betatarget
DB09462GlycerinA/G-specific adenine glycosylasetarget
DB09462GlycerintRNA (cytosine(38)-C(5))-methyltransferasetarget
DB09462GlycerinCytochrome P450 2E1enzyme
DB09462GlycerinRetinal dehydrogenase 1enzyme
DB09462GlycerinPeroxisome proliferator-activated receptor deltatarget
DB09462GlycerinMaleylacetoacetate isomerasetarget
DB09462GlycerinAquaporin-7transporter
DB09462GlycerinAquaporin-9transporter
DB09462GlycerinGlycerol uptake facilitator proteintransporter
DB00581LactuloseEvolved beta-galactosidase subunit alphatarget
DB01046LubiprostoneChloride channel protein 2target
DB01046LubiprostoneCarbonyl reductase [NADPH] 1enzyme
DB00653Magnesium sulfateVoltage-dependent L-type calcium channeltarget
DB04824PhenolphthaleinUDP-glucuronosyltransferase 1-9target
DB04824PhenolphthaleinNuclear receptor subfamily 1 group I member 2target
DB04824PhenolphthaleinNuclear receptor subfamily 1 group I member 3target
DB04824PhenolphthaleinEstrogen receptor alphatarget
DB04824PhenolphthaleinSex hormone-binding globulintarget
DB09268Picosulfuric acidArylsulfate sulfotransferaseenzyme
DB09287Polyethylene glycolP-glycoprotein 1transporter
DB11077Polyethylene glycol 400Oxidoreductase HTATIP2target
DB11077Polyethylene glycol 400Cytochrome P450 4A11enzyme
DB11077Polyethylene glycol 400Alcohol dehydrogenase class-3enzyme
DB11077Polyethylene glycol 400Sulfotransferase 1A1enzyme
DB11077Polyethylene glycol 400Ectonucleotide pyrophosphatase/phosphodiesterase family member 1target
DB11077Polyethylene glycol 400P-glycoprotein 1transporter
DB00545PyridostigmineAcetylcholinesterasetarget
DB00545PyridostigmineCholinesterasetarget
DB00545PyridostigmineAcetylcholinesteraseenzyme
DB00545PyridostigmineCholinesteraseenzyme
DB00545PyridostigmineCytochrome P450 3A4enzyme
DB00140RiboflavinFlavin reductase (NADPH)target
DB00140RiboflavinRiboflavin kinasetarget
DB00140RiboflavinRiboflavin synthasetarget
DB00140RiboflavinAmine oxidase [flavin-containing] Aenzyme
DB00140RiboflavinMethylenetetrahydrofolate reductaseenzyme
DB00140RiboflavinSolute carrier family 22 member 6transporter
DB11365SennosidesReverse transcriptase/RNaseHtarget
DB11365SennosidesAquaporin-3target
DB01390Sodium bicarbonateElectrogenic sodium bicarbonate cotransporter 1transporter
DB01390Sodium bicarbonateSodium bicarbonate cotransporter 3transporter
DB01390Sodium bicarbonateElectroneutral sodium bicarbonate exchanger 1transporter
DB01390Sodium bicarbonateElectrogenic sodium bicarbonate cotransporter 4transporter
DB01390Sodium bicarbonateHydrogen ionstarget
DB01390Sodium bicarbonateSodium-driven chloride bicarbonate exchangertransporter
DB14502Sodium phosphate, dibasicSodium-dependent phosphate transporter 1transporter
DB14502Sodium phosphate, dibasicSodium-dependent phosphate transporter 2transporter
DB14502Sodium phosphate, dibasicSodium-dependent phosphate transport protein 2Atransporter
DB14502Sodium phosphate, dibasicSodium-dependent phosphate transport protein 2Btransporter
DB14502Sodium phosphate, dibasicSodium-dependent phosphate transport protein 2Ctransporter
DB09449Sodium phosphate, monobasicSodium-dependent phosphate transporter 1transporter
DB09449Sodium phosphate, monobasicSodium-dependent phosphate transporter 2transporter
DB09449Sodium phosphate, monobasicSodium-dependent phosphate transport protein 2Atransporter
DB09449Sodium phosphate, monobasicSodium-dependent phosphate transport protein 2Btransporter
DB09449Sodium phosphate, monobasicSodium-dependent phosphate transport protein 2Ctransporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transporter 1transporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transporter 2transporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transport protein 2Atransporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transport protein 2Btransporter
DB14503Sodium phosphate, monobasic, unspecified formSodium-dependent phosphate transport protein 2Ctransporter
DB00391SulpirideDopamine D2 receptortarget
DB00391SulpirideDopamine D3 receptortarget
DB00391SulpirideCholinesteraseenzyme
DB00391SulpirideCarbonic anhydrase 2target
DB00391SulpirideCarbonic anhydrase 3target
DB00391SulpirideSerum albumincarrier
DB00391SulpirideSolute carrier family 22 member 1transporter
DB00391SulpirideSolute carrier family 22 member 2transporter
DB00391SulpirideMultidrug and toxin extrusion protein 1transporter
DB00391SulpirideMultidrug and toxin extrusion protein 2transporter
DB00391SulpirideDopamine D4 receptortarget
DB00391SulpirideSolute carrier family 22 member 3transporter
DB00391SulpirideP-glycoprotein 1transporter
DB00391SulpirideATP-binding cassette sub-family G member 2transporter
DrugDrug NamePhaseStatusCount
DB09341Dextrose, unspecified form0Completed1
DB00929Misoprostol0Not Yet Recruiting1
DB09287Polyethylene glycol0Completed1
DB12013Axelopran1Completed1
DB08890Linaclotide1Completed1
DB12583Maltodextrin1Completed1
DB00218Moxifloxacin1Completed1
DB06480Prucalopride1Completed5
DB00545Pyridostigmine1 / 2Completed1
DB00346Alfuzosin2Completed1
DB06274Alvimopan2Completed1
DB06274Alvimopan2Terminated1
DB12464Bevenopran2Completed1
DB09020Bisacodyl2Completed1
DB09020Bisacodyl2Terminated1
DB11089Docusate2Completed1
DB13112Dolcanatide2Completed1
DB12486Elobixibat2Completed1
DB00898Ethanol2Completed1
DB09462Glycerin2Completed1
DB14811Isatuximab2Active Not Recruiting1
DB04924Itopride2Completed1
DB00581Lactulose2Completed1
DB08890Linaclotide2Completed1
DB06800Methylnaltrexone2Completed2
DB09049Naloxegol2Terminated1
DB01183Naloxone2Completed2
DB11062Octisalate2Recruiting2
DB09535Octocrylene2Recruiting2
DB00497Oxycodone2Completed1
DB09287Polyethylene glycol2Completed3
DB09287Polyethylene glycol2Recruiting1
DB01839Propylene glycol2Completed1
DB06480Prucalopride2Completed5
DB12798Relenopride2Completed1
DB00512Vancomycin2Recruiting1
DB09321Zinc oxide2Recruiting2
DB11089Docusate2 / 3Completed1
DB00327Hydromorphone2 / 3Completed1
DB01046Lubiprostone2 / 3Completed1
DB09049Naloxegol2 / 3Recruiting1
DB01183Naloxone2 / 3Completed1
DB11062Octisalate2 / 3Completed1
DB09535Octocrylene2 / 3Completed1
DB15889Senna leaf2 / 3Completed1
DB11365Sennosides2 / 3Completed1
DB01079Tegaserod2 / 3Terminated1
DB09321Zinc oxide2 / 3Completed1
DB06274Alvimopan3Completed3
DB09020Bisacodyl3Completed2
DB15648Calcium oxide3Completed1
DB01151Desipramine3Completed1
DB11089Docusate3Completed1
DB09462Glycerin3Completed1
DB08890Linaclotide3Completed1
DB01046Lubiprostone3Completed3
DB06800Methylnaltrexone3Completed3
DB11675Mosapride3Completed1
DB09049Naloxegol3Withdrawn1
DB01183Naloxone3Completed1
DB01183Naloxone3Terminated1
DB00497Oxycodone3Completed1
DB00497Oxycodone3Terminated1
DB11158Pectin3Completed1
DB09268Picosulfuric acid3Completed1
DB09287Polyethylene glycol3Completed2
DB09287Polyethylene glycol3Withdrawn2
DB00761Potassium chloride3Completed1
DB06480Prucalopride3Completed8
DB15889Senna leaf3Completed2
DB15889Senna leaf3Suspended1
DB09512Simethicone3Completed1
DB01390Sodium bicarbonate3Completed1
DB09153Sodium chloride3Completed1
DB01638Sorbitol3Completed1
DB02772Sucrose3Completed1
DB01079Tegaserod3Completed1
DB09536Titanium dioxide3Withdrawn1
DB09321Zinc oxide3Withdrawn1
DB00316Acetaminophen4Completed1
DB00316Acetaminophen4Unknown Status1
DB06274Alvimopan4Completed1
DB00181Baclofen4Terminated1
DB09020Bisacodyl4Completed3
DB09020Bisacodyl4Recruiting2
DB09020Bisacodyl4Terminated1
DB00297Bupivacaine4Unknown Status1
DB00482Celecoxib4Completed1
DB01234Dexamethasone4Completed1
DB11089Docusate4Completed2
DB11089Docusate4Terminated3
DB16603Escherichia coli strain Nissle 19174Completed1
DB00187Esmolol4Terminated1
DB00813Fentanyl4Unknown Status1
DB00996Gabapentin4Completed1
DB00996Gabapentin4Unknown Status1
DB00956Hydrocodone4Completed1
DB00956Hydrocodone4Unknown Status1
DB00327Hydromorphone4Completed1
DB00327Hydromorphone4Unknown Status1
DB01050Ibuprofen4Completed1
DB01221Ketamine4Unknown Status1
DB00465Ketorolac4Unknown Status1
DB00581Lactulose4Completed2
DB00581Lactulose4Unknown Status2
DB00281Lidocaine4Terminated1
DB00281Lidocaine4Unknown Status1
DB01046Lubiprostone4Completed4
DB01046Lubiprostone4Terminated1
DB11110Magnesium citrate4Terminated1
DB09104Magnesium hydroxide4Completed1
DB00742Mannitol4Completed1
DB00333Methadone4Unknown Status1
DB06800Methylnaltrexone4Completed1
DB06800Methylnaltrexone4Terminated1
DB00295Morphine4Unknown Status1
DB09049Naloxegol4Terminated3
DB01183Naloxone4Completed1
DB01183Naloxone4Terminated1
DB01183Naloxone4Unknown Status1
DB00104Octreotide4Completed1
DB00904Ondansetron4Completed1
DB01173Orphenadrine4Unknown Status1
DB00497Oxycodone4Completed2
DB00497Oxycodone4Unknown Status1
DB11097Plantago seed4Completed1
DB09287Polyethylene glycol4Completed7
DB09287Polyethylene glycol4Recruiting1
DB09287Polyethylene glycol4Terminated2
DB09287Polyethylene glycol4Unknown Status2
DB06480Prucalopride4Completed2
DB15889Senna leaf4Completed1
DB15889Senna leaf4Terminated2
DB15889Senna leaf4Unknown Status1
DB11365Sennosides4Completed1
DB11365Sennosides4Terminated2
DB11365Sennosides4Unknown Status1
DB01638Sorbitol4Completed1
DB01079Tegaserod4Completed1
DB09536Titanium dioxide4Completed1
DB09536Titanium dioxide4Recruiting1
DB00193Tramadol4Unknown Status1
DB09321Zinc oxide4Completed1
DB09321Zinc oxide4Recruiting1
DB00829DiazepamNot AvailableCompleted1
DB11089DocusateNot AvailableCompleted1
DB00581LactuloseNot AvailableUnknown Status2
DB01046LubiprostoneNot AvailableCompleted3
DB01046LubiprostoneNot AvailableTerminated1
DB06800MethylnaltrexoneNot AvailableTerminated1
DB11062OctisalateNot AvailableCompleted1
DB09535OctocryleneNot AvailableCompleted1
DB11097Plantago seedNot AvailableCompleted1
DB09287Polyethylene glycolNot AvailableCompleted1
DB09287Polyethylene glycolNot AvailableTerminated1
DB06480PrucaloprideNot AvailableCompleted2
DB06480PrucaloprideNot AvailableWithdrawn1
DB15889Senna leafNot AvailableCompleted1
DB11365SennosidesNot AvailableCompleted1
DB08839SerotoninNot AvailableCompleted1
DB01079TegaserodNot AvailableTerminated1
DB01079TegaserodNot AvailableUnknown Status1
DB09321Zinc oxideNot AvailableCompleted1