Hot Flashes

Also known as: Hotflashes / Hot Flash / Hot Flushes / Hot flush / Climacteric flushing (disorder) / Menopause flushing / Hot flushes menopausal / Menopausal hot flushes / Feeling of hot flushes / Hot flushes, menopausal / Hot flushes (finding) / Hot flash (finding) / Flush hot / Menopausal flushing (finding) / Flash hot / Hot flushes NOS

Drug	Drug Name	Drug Description
DB06724	Calcium carbonate	An ionic compound used as a calcium supplement or antacid used for the symptomatic relief of heartburn, acid indigestion, and sour stomach.
DB00575	Clonidine	An alpha-2 adrenergic agonist used to treat hypertension and severe cancer pain, among other conditions, and to treat withdrawal symptoms from various substances. It is also used to aid in the diagnosis of pheochromocytoma and to prevent migraines.
DB06700	Desvenlafaxine	An antidepressant agent and SNRI used for the treatment of major depressive disorders in adults.
DB00370	Mirtazapine	A tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
DB01323	St. John's Wort	An herbal ingredient used in non-prescription therapeutic products for the short-term treatment of minor skin irritations, insomnia, depression, and anxiety.

Drug	Drug Name	Target	Type
DB00575	Clonidine	Alpha-2A adrenergic receptor	target
DB00575	Clonidine	Cytochrome P450 2D6	enzyme
DB00575	Clonidine	Alpha-2B adrenergic receptor	target
DB00575	Clonidine	Alpha-2C adrenergic receptor	target
DB00575	Clonidine	Solute carrier family 22 member 3	transporter
DB00575	Clonidine	Solute carrier family 22 member 5	transporter
DB00575	Clonidine	Solute carrier family 22 member 4	transporter
DB00575	Clonidine	Cytochrome P450 1A2	enzyme
DB00575	Clonidine	Cytochrome P450 3A4	enzyme
DB00575	Clonidine	Cytochrome P450 1A1	enzyme
DB00575	Clonidine	Cytochrome P450 3A5	enzyme
DB00575	Clonidine	Alpha-1A adrenergic receptor	target
DB00575	Clonidine	Alpha-1B adrenergic receptor	target
DB00575	Clonidine	Alpha-1D adrenergic receptor	target
DB00575	Clonidine	Serum albumin	carrier
DB06700	Desvenlafaxine	Cytochrome P450 3A4	enzyme
DB06700	Desvenlafaxine	Sodium-dependent serotonin transporter	target
DB06700	Desvenlafaxine	Sodium-dependent noradrenaline transporter	target
DB06700	Desvenlafaxine	Cytochrome P450 2D6	enzyme
DB06700	Desvenlafaxine	Sodium-dependent dopamine transporter	target
DB00370	Mirtazapine	5-hydroxytryptamine receptor 2A	target
DB00370	Mirtazapine	5HT3 serotonin receptor	target
DB00370	Mirtazapine	Alpha-2A adrenergic receptor	target
DB00370	Mirtazapine	5-hydroxytryptamine receptor 2C	target
DB00370	Mirtazapine	Kappa-type opioid receptor	target
DB00370	Mirtazapine	Histamine H1 receptor	target
DB00370	Mirtazapine	Cytochrome P450 1A2	enzyme
DB00370	Mirtazapine	Cytochrome P450 3A4	enzyme
DB00370	Mirtazapine	Cytochrome P450 2D6	enzyme
DB00370	Mirtazapine	Alpha-1 adrenergic receptors	target
DB00370	Mirtazapine	Sodium-dependent serotonin transporter	transporter
DB01323	St. John's Wort	P-glycoprotein 1	transporter
DB01323	St. John's Wort	Cytochrome P450 3A4	enzyme
DB01323	St. John's Wort	Cytochrome P450 2D6	enzyme
DB01323	St. John's Wort	Cytochrome P450 2C19	enzyme

Drug	Drug Name	Phase	Status	Count
DB00297	Bupivacaine	0	Completed	1
DB13975	Black cohosh	1	Terminated	1
DB14726	Dabigatran	1	Completed	1
DB00736	Esomeprazole	1	Completed	1
DB05052	MF101	1	Unknown Status	1
DB00218	Moxifloxacin	1	Active Not Recruiting	1
DB13975	Black cohosh	1 / 2	Completed	1
DB01065	Melatonin	1 / 2	Terminated	1
DB15458	Norleucine	1 / 2	Completed	1
DB13975	Black cohosh	2	Completed	2
DB13975	Black cohosh	2	Withdrawn	1
DB00297	Bupivacaine	2	Active Not Recruiting	1
DB00297	Bupivacaine	2	Completed	1
DB00297	Bupivacaine	2	Terminated	1
DB00575	Clonidine	2	Active Not Recruiting	1
DB00080	Daptomycin	2	Completed	1
DB06374	Elacestrant	2	Completed	1
DB06374	Elacestrant	2	Terminated	1
DB12235	Estetrol	2	Completed	1
DB00783	Estradiol	2	Completed	1
DB13952	Estradiol acetate	2	Completed	1
DB15669	Fezolinetant	2	Completed	3
DB00996	Gabapentin	2	Completed	2
DB05052	MF101	2	Completed	1
DB01377	Magnesium oxide	2	Completed	2
DB00603	Medroxyprogesterone acetate	2	Completed	1
DB01062	Oxybutynin	2	Completed	1
DB15264	PD-0299685	2	Completed	1
DB00715	Paroxetine	2	Completed	1
DB00734	Risperidone	2	Completed	1
DB09153	Sodium chloride	2	Active Not Recruiting	1
DB09153	Sodium chloride	2	Completed	1
DB01591	Solifenacin	2	Active Not Recruiting	1
DB01323	St. John's Wort	2	Terminated	1
DB00675	Tamoxifen	2	Completed	1
DB11558	Toluene	2	Completed	1
DB15530	Trifolium pratense pollen	2	Completed	1
DB01708	Prasterone	2 / 3	Completed	1
DB16080	Acolbifene	3	Completed	1
DB13975	Black cohosh	3	Unknown Status	1
DB00215	Citalopram	3	Completed	1
DB00286	Conjugated estrogens	3	Completed	1
DB04839	Cyproterone acetate	3	Completed	1
DB06700	Desvenlafaxine	3	Completed	1
DB01395	Drospirenone	3	Completed	1
DB00783	Estradiol	3	Completed	4
DB00783	Estradiol	3	Unknown Status	1
DB15669	Fezolinetant	3	Completed	5
DB00996	Gabapentin	3	Completed	7
DB00014	Goserelin	3	Unknown Status	1
DB05052	MF101	3	Unknown Status	1
DB00603	Medroxyprogesterone acetate	3	Completed	2
DB00351	Megestrol acetate	3	Completed	1
DB01062	Oxybutynin	3	Completed	1
DB00715	Paroxetine	3	Completed	1
DB01708	Prasterone	3	Completed	1
DB00230	Pregabalin	3	Completed	1
DB00396	Progesterone	3	Completed	1
DB00391	Sulpiride	3	Completed	1
DB09317	Synthetic Conjugated Estrogens, A	3	Completed	1
DB00624	Testosterone	3	Completed	1
DB00285	Venlafaxine	3	Completed	1
DB00285	Venlafaxine	3	Terminated	1
DB00297	Bupivacaine	4	Terminated	1
DB06700	Desvenlafaxine	4	Terminated	1
DB00378	Dydrogesterone	4	Recruiting	1
DB00783	Estradiol	4	Completed	1
DB00783	Estradiol	4	Recruiting	1
DB00644	Gonadorelin	4	Completed	1
DB12007	Isoflavone	4	Completed	1
DB00007	Leuprolide	4	Completed	2
DB00367	Levonorgestrel	4	Completed	1
DB01224	Quetiapine	4	Completed	1
DB14101	Soy isoflavones	4	Completed	1
DB09068	Vortioxetine	4	Completed	1
DB03128	Acetylcholine	Not Available	Recruiting	1
DB13975	Black cohosh	Not Available	Completed	1
DB00215	Citalopram	Not Available	Active Not Recruiting	1
DB00215	Citalopram	Not Available	Completed	1
DB00286	Conjugated estrogens	Not Available	Terminated	1
DB00286	Conjugated estrogens	Not Available	Unknown Status	1
DB01175	Escitalopram	Not Available	Active Not Recruiting	1
DB01175	Escitalopram	Not Available	Completed	1
DB00783	Estradiol	Not Available	Completed	1
DB00783	Estradiol	Not Available	Terminated	1
DB00783	Estradiol	Not Available	Unknown Status	1
DB00472	Fluoxetine	Not Available	Completed	1
DB00472	Fluoxetine	Not Available	Unknown Status	1
DB00996	Gabapentin	Not Available	Active Not Recruiting	1
DB00996	Gabapentin	Not Available	Completed	2
DB00325	Nitroprusside	Not Available	Recruiting	1
DB00368	Norepinephrine	Not Available	Recruiting	1
DB00715	Paroxetine	Not Available	Terminated	1
DB00396	Progesterone	Not Available	Completed	1
DB00396	Progesterone	Not Available	Unknown Status	1
DB01104	Sertraline	Not Available	Active Not Recruiting	1
DB00675	Tamoxifen	Not Available	Active Not Recruiting	1
DB00871	Terbutaline	Not Available	Recruiting	1
DB00285	Venlafaxine	Not Available	Active Not Recruiting	1
DB00285	Venlafaxine	Not Available	Completed	2
DB00285	Venlafaxine	Not Available	Withdrawn	1
DB06684	Vilazodone	Not Available	Completed	1
DB00425	Zolpidem	Not Available	Completed	1