Pruritus

Also known as: Pruritis generalized / Pruritis / Itch / Pruritus NOS / Itching / Unspecified pruritic disorder / Pruritus cutaneous / Itchy skin / Itchy

DrugDrug NameDrug Description
DB09488AcrivastineAn antihistamine agent used for the symptomatic relief of seasonal allergic rhinitis such as sneezing, rhinorrhea, pruritus, lacrimation, and nasal congestion.
DB01246AlimemazineAn antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria.
DB00288AmcinonideA topical corticosteroid used in the treatment of inflammation and pruritus due to a variety of dermatoses.
DB13489BamipineNot Annotated
DB01432CholestyramineA bile acid sequestrant used as an adjunct in the reduction of elevated serum cholesterol in patients with primary hypercholesterolemia, and for the relief of pruritus associated with partial biliary obstruction.
DB00434CyproheptadineA combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome.
DB13679DexchlorpheniramineDexchlorpheniramine is a potent S-enantiomer of chlorpheniramine. The salt form dexchlorpheniramine maleate as the active ingredient is available as a prescription drug indicated for adjunctive therapy for allergic and anaphylactic...
DB01142DoxepinA psychotropic agent used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
DB01047FluocinonideA high potency corticosteroid commonly used topically for a number of inflammatory skin conditions.
DB14544Hydrocortisone valerateA corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
DB00557HydroxyzineAn antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria.
DB00764MometasoneA corticosteroid with no indications.
DB14512Mometasone furoateA corticosteroid used to treat asthma, allergic rhinitis, nasal congestion, nasal polyps, dermatitis, and pruritus.
DB01183NaloxoneAn opioid receptor antagonist used to rapidly reverse an opioid overdose. Also included in some drug formulations as an abuse deterrent to prevent injection.
DB12877OxatomideOxatomide has been used in trials studying the treatment of Muscular Dystrophy, Duchenne.
DB11614RupatadineA selective histamine H1 receptor antagonist and platelet activating factor (PAF) antagonist used to treat allergic rhinitis.
DB09321Zinc oxideA mineral ingredient of various pharmacological preparations to treat diaper dermatitis and other skin conditions, to protect the epidermis, and to prevent sunburn.
DrugDrug NameTargetType
DB09488AcrivastineHistamine H1 receptortarget
DB01246AlimemazineHistamine H1 receptortarget
DB00288AmcinonideGlucocorticoid receptortarget
DB00288AmcinonideAnnexin A1target
DB00288AmcinonideCytochrome P450 3A4enzyme
DB00288AmcinonideCytochrome P450 3A5enzyme
DB01432CholestyramineBile acidstarget
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Atarget
DB00434CyproheptadineHistamine H1 receptortarget
DB00434CyproheptadineMuscarinic acetylcholine receptor M1target
DB00434CyproheptadineMuscarinic acetylcholine receptor M2target
DB00434CyproheptadineMuscarinic acetylcholine receptor M3target
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Ctarget
DB00434CyproheptadineUDP-glucuronosyltransferase 1-3enzyme
DB00434Cyproheptadine5-hydroxytryptamine receptor 7target
DB00434CyproheptadineUDP-glucuronosyltransferase 2B10enzyme
DB00434CyproheptadineUDP-glucuronosyltransferase 1-4enzyme
DB00434Cyproheptadine5-hydroxytryptamine receptor 2Btarget
DB00434CyproheptadineHistamine H2 receptortarget
DB00434CyproheptadineSolute carrier family 22 member 1transporter
DB00434CyproheptadineSerum albumincarrier
DB13679DexchlorpheniramineCytochrome P450 2D6enzyme
DB01142DoxepinSodium-dependent serotonin transportertarget
DB01142DoxepinSodium-dependent noradrenaline transportertarget
DB01142DoxepinHistamine H1 receptortarget
DB01142DoxepinHistamine H2 receptortarget
DB01142DoxepinCytochrome P450 2D6enzyme
DB01142DoxepinMuscarinic acetylcholine receptor M1target
DB01142DoxepinMuscarinic acetylcholine receptor M2target
DB01142DoxepinMuscarinic acetylcholine receptor M3target
DB01142DoxepinMuscarinic acetylcholine receptor M4target
DB01142DoxepinMuscarinic acetylcholine receptor M5target
DB01142DoxepinAlpha-1A adrenergic receptortarget
DB01142Doxepin5-hydroxytryptamine receptor 1Atarget
DB01142Doxepin5-hydroxytryptamine receptor 2Atarget
DB01142DoxepinCytochrome P450 2C19enzyme
DB01142DoxepinCytochrome P450 2C9enzyme
DB01142DoxepinCytochrome P450 1A2enzyme
DB01142DoxepinP-glycoprotein 1transporter
DB01142Doxepin5-hydroxytryptamine receptor 2Btarget
DB01142Doxepin5-hydroxytryptamine receptor 2Ctarget
DB01142DoxepinAlpha-1B adrenergic receptortarget
DB01142DoxepinAlpha-1D adrenergic receptortarget
DB01142DoxepinCytochrome P450 3A4enzyme
DB01142Doxepin5-hydroxytryptamine receptor 6target
DB01142DoxepinHistamine H4 receptortarget
DB01142DoxepinPotassium voltage-gated channel subfamily H member 2target
DB01142DoxepinSerum albumincarrier
DB01142DoxepinAlpha-1-acid glycoprotein 1carrier
DB01047FluocinonideCorticosteroid-binding globulincarrier
DB01047FluocinonideGlucocorticoid receptortarget
DB01047FluocinonideSmoothened homologtarget
DB01047FluocinonideCytochrome P450 3A4enzyme
DB01047FluocinonideCytochrome P450 3A5enzyme
DB14544Hydrocortisone valerateAnnexin A1target
DB14544Hydrocortisone valerateGlucocorticoid receptortarget
DB14544Hydrocortisone valerateSex hormone-binding globulincarrier
DB14544Hydrocortisone valerateCytochrome P450 3A4enzyme
DB14544Hydrocortisone valerateCytochrome P450 3A5enzyme
DB14544Hydrocortisone valerateCytochrome P450 3A7enzyme
DB14544Hydrocortisone valerateP-glycoprotein 1transporter
DB14544Hydrocortisone valerateSolute carrier organic anion transporter family member 1A2transporter
DB14544Hydrocortisone valerateATP-binding cassette sub-family G member 2transporter
DB14544Hydrocortisone valerateCytochrome P450 11B1, mitochondrialenzyme
DB14544Hydrocortisone valerateCytochrome P450 11B2, mitochondrialenzyme
DB14544Hydrocortisone valerateCytochrome P450 2C8enzyme
DB14544Hydrocortisone valerateCorticosteroid-binding globulincarrier
DB14544Hydrocortisone valerateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14544Hydrocortisone valerate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14544Hydrocortisone valerateSolute carrier family 22 member 8transporter
DB00557HydroxyzineHistamine H1 receptortarget
DB00557HydroxyzineCytochrome P450 2D6enzyme
DB00557HydroxyzineCytochrome P450 3A4enzyme
DB00557HydroxyzineCytochrome P450 3A5enzyme
DB00557HydroxyzinePotassium voltage-gated channel subfamily H member 2target
DB00557HydroxyzineP-glycoprotein 1transporter
DB00557HydroxyzineSerum albumincarrier
DB00764MometasoneGlucocorticoid receptortarget
DB00764MometasoneCytochrome P450 2C8enzyme
DB00764MometasoneProgesterone receptortarget
DB00764MometasoneCytochrome P450 3A4enzyme
DB00764MometasoneCytochrome P450 3A5enzyme
DB14512Mometasone furoateGlucocorticoid receptortarget
DB14512Mometasone furoateCytochrome P450 2C8enzyme
DB14512Mometasone furoateProgesterone receptortarget
DB14512Mometasone furoateCytochrome P450 3A4enzyme
DB14512Mometasone furoateCytochrome P450 3A5enzyme
DB01183NaloxoneMu-type opioid receptortarget
DB01183NaloxoneEstrogen receptor alphatarget
DB01183NaloxoneCyclic AMP-responsive element-binding protein 1target
DB01183NaloxoneDelta-type opioid receptortarget
DB01183NaloxoneSolute carrier organic anion transporter family member 1A2transporter
DB01183NaloxoneP-glycoprotein 1transporter
DB01183NaloxoneKappa-type opioid receptortarget
DB01183NaloxoneCytochrome P450 3A4enzyme
DB01183NaloxoneSerum albumincarrier
DB01183NaloxoneToll-like receptor 4target
DB01183NaloxoneLiver carboxylesterase 1target
DB01183NaloxoneUDP-glucuronosyltransferase 1-1enzyme
DB11614RupatadineCytochrome P450 3A4enzyme
DB11614RupatadineCytochrome P450 2C9enzyme
DB11614RupatadineCytochrome P450 2C19enzyme
DB11614RupatadineCytochrome P450 2D6enzyme
DB11614RupatadinePlatelet-activating factor receptortarget
DB11614RupatadineHistamine H1 receptortarget
DrugDrug NamePhaseStatusCount
DB00683Midazolam0Recruiting1
DB00818Propofol0Not Yet Recruiting1
DB04890Bepotastine1Completed1
DB00996Gabapentin1Withdrawn1
DB12580Tradipitant1Completed1
DB00316Acetaminophen1 / 2Completed1
DB00083Botulinum toxin type A1 / 2Completed1
DB06774Capsaicin1 / 2Completed1
DB14091Carbomer homopolymer type C1 / 2Completed1
DB00321Amitriptyline2Terminated1
DB00673Aprepitant2Completed1
DB05104Asimadoline2Completed1
DB02300Calcipotriol2Completed1
DB01003Cromoglicic acid2Completed1
DB11938Difelikefalin2Active Not Recruiting1
DB11938Difelikefalin2Completed2
DB11938Difelikefalin2Recruiting1
DB01075Diphenhydramine2Completed1
DB12159Dupilumab2Recruiting1
DB00889Granisetron2Unknown Status1
DB12154Itacitinib2Withdrawn1
DB01221Ketamine2Terminated1
DB00281Lidocaine2Terminated1
DB00295Morphine2Recruiting1
DB00295Morphine2Unknown Status1
DB00844Nalbuphine2Recruiting1
DB01183Naloxone2Completed1
DB00704Naltrexone2Not Yet Recruiting2
DB12427Orvepitant2Withdrawn1
DB16280Pegcantratinib2Completed2
DB12973Serlopitant2Completed4
DB12973Serlopitant2Terminated1
DB01104Sertraline2Completed1
DB00193Tramadol2Terminated1
DB16350Vixarelimab2Completed1
DB16350Vixarelimab2Recruiting1
DB14487Zinc acetate2Completed1
DB09321Zinc oxide2Not Yet Recruiting1
DB09321Zinc oxide2Terminated1
DB00295Morphine2 / 3Completed1
DB00844Nalbuphine2 / 3Completed3
DB01183Naloxone2 / 3Completed1
DB04890Bepotastine3Completed1
DB00341Cetirizine3Completed1
DB00996Gabapentin3Completed1
DB00295Morphine3Completed1
DB00844Nalbuphine3Completed1
DB11062Octisalate3Completed1
DB09535Octocrylene3Completed1
DB00497Oxycodone3Completed1
DB12973Serlopitant3Completed2
DB12973Serlopitant3Terminated1
DB09321Zinc oxide3Completed1
DB00673Aprepitant4Terminated1
DB00297Bupivacaine4Completed1
DB00341Cetirizine4Terminated1
DB01234Dexamethasone4Completed1
DB00153Ergocalciferol4Completed1
DB00950Fexofenadine4Completed2
DB00557Hydroxyzine4Completed1
DB06282Levocetirizine4Completed2
DB00295Morphine4Completed2
DB00904Ondansetron4Completed1
DB00904Ondansetron4Terminated1
DB01069Promethazine4Not Yet Recruiting1
DB08604Triclosan4Completed1
DB00518AlbendazoleNot AvailableCompleted1
DB00673AprepitantNot AvailableCompleted1
DB00297BupivacaineNot AvailableRecruiting1
DB06774CapsaicinNot AvailableUnknown Status1
DB14184CinnamaldehydeNot AvailableUnknown Status1
DB00967DesloratadineNot AvailableCompleted2
DB01234DexamethasoneNot AvailableCompleted1
DB00813FentanylNot AvailableCompleted1
DB00996GabapentinNot AvailableCompleted1
DB00996GabapentinNot AvailableUnknown Status1
DB00602IvermectinNot AvailableCompleted1
DB00920KetotifenNot AvailableCompleted1
DB06282LevocetirizineNot AvailableCompleted1
DB00825LevomentholNot AvailableUnknown Status1
DB00455LoratadineNot AvailableCompleted1
DB00295MorphineNot AvailableRecruiting1
DB01183NaloxoneNot AvailableCompleted1
DB00904OndansetronNot AvailableCompleted1
DB15889Senna leafNot AvailableCompleted1