NYHA Functional Class II-III Pulmonary arterial hypertension

Drug	Drug Name	Drug Description
DB00203	Sildenafil	A phosphodiesterase inhibitor used for the treatment of erectile dysfunction.

Drug	Drug Name	Target	Type
DB00203	Sildenafil	cGMP-specific 3',5'-cyclic phosphodiesterase	target
DB00203	Sildenafil	Cytochrome P450 2C9	enzyme
DB00203	Sildenafil	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
DB00203	Sildenafil	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	target
DB00203	Sildenafil	Cytochrome P450 3A4	enzyme
DB00203	Sildenafil	Cytochrome P450 3A5	enzyme
DB00203	Sildenafil	Cytochrome P450 3A7	enzyme
DB00203	Sildenafil	Multidrug resistance-associated protein 4	transporter
DB00203	Sildenafil	Multidrug resistance-associated protein 5	transporter
DB00203	Sildenafil	Multidrug resistance-associated protein 7	transporter
DB00203	Sildenafil	Cytochrome P450 2C19	enzyme
DB00203	Sildenafil	Cytochrome P450 2D6	enzyme
DB00203	Sildenafil	Cytochrome P450 2E1	enzyme
DB00203	Sildenafil	Solute carrier organic anion transporter family member 1B1	transporter
DB00203	Sildenafil	P-glycoprotein 1	transporter
DB00203	Sildenafil	Ornithine decarboxylase	target
DB00203	Sildenafil	Programmed cell death 1 ligand 1	target

Drug	Drug Name	Phase	Status	Count