Bipolar 1 Disorder

Also known as: Bipolar Disease Type I / Bipolar Type I Disorder / Bipolar I disorder / Bipolar disorder / Bipolar I disorder (disorder)

DrugDrug NameDrug Description
DB01238AripiprazoleAn atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's syndrome.
DB06216AsenapineAn atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia.
DB00564CarbamazepineAn anticonvulsant used to treat various types of seizures and pain resulting from trigeminal neuralgia.
DB06016CariprazineAn atypical antipsychotic used to treat schizophrenia and acute manic or mixed episodes due to bipolar I disorder.
DB00472FluoxetineA selective serotonin reuptake inhibitor used to treat major depressive disorder, bulimia, OCD, premenstrual dysphoric disorder, panic disorder, and bipolar I.
DB00555LamotrigineA phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
DB00408LoxapineA antipsychotic used for the treatment of schizophrenia.
DB08815LurasidoneAn atypical antipsychotic used to treat schizophrenia and depressive episodes associated with bipolar I disorder.
DB00334OlanzapineAn antipsychotic drug used in the management of schizophrenia, bipolar 1 disorder, and agitation associated with these disorders.
DB01224QuetiapineA psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder.
DB00734RisperidoneA second-generation antipsychotic medication used to treat a number of mental health disorders including schizophrenia, bipolar mania, psychosis, or as an adjunct in severe depression.
DB12543SamidorphanA novel opioid-system modulator, similar to naltrexone, that functions primarily as a μ-opioid receptor antagonist in vivo and is used primarily in combination with antipsychotics to reduce their metabolic dysfunction-associated adverse effects.
DB00246ZiprasidoneAn atypical antipsychotic used to manage schizophrenia, bipolar mania, and agitation in patients with schizophrenia.
DrugDrug NameTargetType
DB01238AripiprazoleDopamine D2 receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Atarget
DB01238AripiprazoleCytochrome P450 3A4enzyme
DB01238AripiprazoleCytochrome P450 2D6enzyme
DB01238Aripiprazole5-hydroxytryptamine receptor 1Btarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Dtarget
DB01238Aripiprazole5-hydroxytryptamine receptor 1Etarget
DB01238AripiprazoleDopamine D1 receptortarget
DB01238AripiprazoleDopamine D5 receptortarget
DB01238AripiprazoleDopamine D3 receptortarget
DB01238AripiprazoleDopamine D4 receptortarget
DB01238Aripiprazole5-hydroxytryptamine receptor 2Ctarget
DB01238Aripiprazole5-hydroxytryptamine receptor 3Atarget
DB01238Aripiprazole5-hydroxytryptamine receptor 6target
DB01238Aripiprazole5-hydroxytryptamine receptor 7target
DB01238AripiprazoleHistamine H1 receptortarget
DB01238AripiprazoleAlpha-1A adrenergic receptortarget
DB01238AripiprazoleAlpha-1B adrenergic receptortarget
DB01238AripiprazoleAlpha-2A adrenergic receptortarget
DB01238AripiprazoleAlpha-2B adrenergic receptortarget
DB01238AripiprazoleAlpha-2C adrenergic receptortarget
DB01238AripiprazoleCytochrome P450 3A5enzyme
DB01238AripiprazoleCytochrome P450 3A7enzyme
DB01238AripiprazoleSerum albumincarrier
DB01238Aripiprazole5-hydroxytryptamine receptor 2Btarget
DB01238Aripiprazole5-hydroxytryptamine receptor 5Atarget
DB01238AripiprazoleBeta-1 adrenergic receptortarget
DB01238AripiprazoleBeta-2 adrenergic receptortarget
DB01238AripiprazoleHistamine H2 receptortarget
DB01238AripiprazoleHistamine H3 receptortarget
DB01238AripiprazoleHistamine H4 receptortarget
DB01238AripiprazoleMuscarinic acetylcholine receptor M1target
DB01238AripiprazoleMuscarinic acetylcholine receptor M2target
DB01238AripiprazoleMuscarinic acetylcholine receptor M3target
DB01238AripiprazoleMuscarinic acetylcholine receptor M4target
DB01238AripiprazoleMuscarinic acetylcholine receptor M5target
DB01238AripiprazoleKappa-type opioid receptortarget
DB01238AripiprazoleMu-type opioid receptortarget
DB01238AripiprazoleDelta-type opioid receptortarget
DB01238AripiprazoleGlutamate (NMDA) receptortarget
DB01238AripiprazoleSodium-dependent dopamine transportertarget
DB01238AripiprazoleSodium-dependent serotonin transportertarget
DB06216Asenapine5-hydroxytryptamine receptor 1Atarget
DB06216Asenapine5-hydroxytryptamine receptor 1Btarget
DB06216Asenapine5-hydroxytryptamine receptor 2Atarget
DB06216Asenapine5-hydroxytryptamine receptor 2Btarget
DB06216Asenapine5-hydroxytryptamine receptor 2Ctarget
DB06216Asenapine5-hydroxytryptamine receptor 6target
DB06216Asenapine5-hydroxytryptamine receptor 7target
DB06216AsenapineAlpha-2A adrenergic receptortarget
DB06216AsenapineAlpha-2B adrenergic receptortarget
DB06216AsenapineAlpha-2C adrenergic receptortarget
DB06216AsenapineAlpha-1A adrenergic receptortarget
DB06216AsenapineDopamine D1 receptortarget
DB06216AsenapineDopamine D2 receptortarget
DB06216AsenapineDopamine D3 receptortarget
DB06216AsenapineDopamine D4 receptortarget
DB06216AsenapineHistamine H1 receptortarget
DB06216AsenapineHistamine H2 receptortarget
DB06216AsenapineCytochrome P450 1A2enzyme
DB06216AsenapineCytochrome P450 2D6enzyme
DB06216Asenapine5-hydroxytryptamine receptor 5Atarget
DB06216AsenapineUDP-glucuronosyltransferase 1-4enzyme
DB06216AsenapineCytochrome P450 3A4enzyme
DB06216AsenapineBeta-1 adrenergic receptortarget
DB06216AsenapineBeta-2 adrenergic receptortarget
DB06216AsenapineSerum albumincarrier
DB06216Asenapinealpha1-acid glycoproteincarrier
DB00564CarbamazepineVoltage-gated sodium channel alpha subunittarget
DB00564CarbamazepineCytochrome P450 2C8enzyme
DB00564CarbamazepineCytochrome P450 2B6enzyme
DB00564CarbamazepineCytochrome P450 3A4enzyme
DB00564CarbamazepineCytochrome P450 1A2enzyme
DB00564CarbamazepineCytochrome P450 2C19enzyme
DB00564CarbamazepineCytochrome P450 2C9enzyme
DB00564CarbamazepineP-glycoprotein 1transporter
DB00564CarbamazepineCytochrome P450 3A5enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 2B7enzyme
DB00564CarbamazepineRalA-binding protein 1transporter
DB00564CarbamazepineCanalicular multispecific organic anion transporter 1transporter
DB00564CarbamazepineNeuronal acetylcholine receptor subunit alpha-4target
DB00564CarbamazepineNuclear receptor subfamily 1 group I member 2target
DB00564CarbamazepineUDP-glucuronosyltransferase 1-1enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 1-6enzyme
DB00564CarbamazepineUDP-glucuronosyltransferase 1-7enzyme
DB06016CariprazineDopamine D3 receptortarget
DB06016CariprazineDopamine D2 receptortarget
DB06016CariprazineCytochrome P450 3A4enzyme
DB06016CariprazineCytochrome P450 2D6enzyme
DB06016Cariprazine5-hydroxytryptamine receptor 1Atarget
DB06016Cariprazine5-hydroxytryptamine receptor 2Btarget
DB06016Cariprazine5-hydroxytryptamine receptor 2Atarget
DB06016CariprazineHistamine H1 receptortarget
DB00472FluoxetineSodium-dependent serotonin transportertarget
DB00472FluoxetineCytochrome P450 2C9enzyme
DB00472FluoxetineCytochrome P450 2D6enzyme
DB00472FluoxetineCYP2B proteinenzyme
DB00472FluoxetineCytochrome P450 1A2enzyme
DB00472FluoxetineCytochrome P450 3A4enzyme
DB00472FluoxetineCytochrome P450 2C19enzyme
DB00472FluoxetineP-glycoprotein 1transporter
DB00472FluoxetineCytochrome P450 2B6enzyme
DB00472FluoxetineCytochrome P450 3A5enzyme
DB00472FluoxetineSerum albumincarrier
DB00472FluoxetineAlpha-1-acid glycoprotein 1carrier
DB00472FluoxetinePotassium voltage-gated channel subfamily H member 2target
DB00472Fluoxetine5-hydroxytryptamine receptor 2Ctarget
DB00472FluoxetineCyclin-dependent kinases regulatory subunit 1target
DB00472FluoxetineNeuronal acetylcholine receptor subunit alpha-2target
DB00472FluoxetineNeuronal acetylcholine receptor subunit alpha-3target
DB00472FluoxetineNeuronal acetylcholine receptor subunit beta-4target
DB00555LamotrigineVoltage-gated sodium channel alpha subunittarget
DB00555LamotrigineUDP-glucuronosyltransferases (UGTs)enzyme
DB00555LamotrigineP-glycoprotein 1transporter
DB00555LamotrigineDihydrofolate reductaseenzyme
DB00555Lamotrigine5-hydroxytryptamine receptor 3Atarget
DB00555LamotrigineVoltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)target
DB00555LamotrigineAdenosine receptor A1target
DB00555LamotrigineAdenosine receptor A2atarget
DB00555LamotrigineAlpha-1A adrenergic receptortarget
DB00555LamotrigineAlpha-2A adrenergic receptortarget
DB00555LamotrigineBeta-1 adrenergic receptortarget
DB00555LamotrigineD(1) dopamine receptortarget
DB00555LamotrigineDopamine D2 receptortarget
DB00555LamotrigineGABA(A) Receptortarget
DB00555LamotrigineGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00555LamotrigineHistamine H1 receptortarget
DB00555LamotrigineKappa-type opioid receptortarget
DB00555LamotrigineAcetylcholine receptor subunit alphatarget
DB00555Lamotrigine5-hydroxytryptamine receptor 2Atarget
DB00555LamotrigineSolute carrier family 22 member 2transporter
DB00555LamotrigineSerum albumincarrier
DB00555LamotrigineSolute carrier family 22 member 1transporter
DB00555LamotrigineGlutamate receptor 1target
DB00408LoxapineDopamine D1 receptortarget
DB00408LoxapineDopamine D2 receptortarget
DB00408Loxapine5-hydroxytryptamine receptor 2Atarget
DB00408Loxapine5-hydroxytryptamine receptor 2Ctarget
DB00408Loxapine5-hydroxytryptamine receptor 1Atarget
DB00408Loxapine5-hydroxytryptamine receptor 1Btarget
DB00408Loxapine5-hydroxytryptamine receptor 1Dtarget
DB00408Loxapine5-hydroxytryptamine receptor 1Etarget
DB00408Loxapine5-hydroxytryptamine receptor 3Atarget
DB00408Loxapine5-hydroxytryptamine receptor 5Atarget
DB00408Loxapine5-hydroxytryptamine receptor 6target
DB00408Loxapine5-hydroxytryptamine receptor 7target
DB00408LoxapineAlpha-1A adrenergic receptortarget
DB00408LoxapineAlpha-1B adrenergic receptortarget
DB00408LoxapineAlpha-2A adrenergic receptortarget
DB00408LoxapineAlpha-2B adrenergic receptortarget
DB00408LoxapineAlpha-2C adrenergic receptortarget
DB00408LoxapineBeta-1 adrenergic receptortarget
DB00408LoxapineMuscarinic acetylcholine receptor M1target
DB00408LoxapineMuscarinic acetylcholine receptor M2target
DB00408LoxapineMuscarinic acetylcholine receptor M3target
DB00408LoxapineMuscarinic acetylcholine receptor M4target
DB00408LoxapineMuscarinic acetylcholine receptor M5target
DB00408LoxapineD(1) dopamine receptortarget
DB00408LoxapineDopamine D3 receptortarget
DB00408LoxapineDopamine D4 receptortarget
DB00408LoxapineDopamine D5 receptortarget
DB00408LoxapineHistamine H1 receptortarget
DB00408LoxapineHistamine H2 receptortarget
DB00408LoxapineHistamine H4 receptortarget
DB00408LoxapineSodium-dependent serotonin transportertarget
DB00408LoxapineSodium-dependent noradrenaline transportertarget
DB00408LoxapineSodium-dependent dopamine transportertarget
DB08815LurasidoneCytochrome P450 3A4enzyme
DB08815LurasidoneDopamine D2 receptortarget
DB08815Lurasidone5-hydroxytryptamine receptor 2Atarget
DB08815Lurasidone5-hydroxytryptamine receptor 7target
DB08815Lurasidone5-hydroxytryptamine receptor 1Atarget
DB08815LurasidoneAlpha-2C adrenergic receptortarget
DB08815LurasidoneAlpha-2A adrenergic receptortarget
DB00334OlanzapineDopamine D1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M1target
DB00334OlanzapineMuscarinic acetylcholine receptor M3target
DB00334Olanzapine5-hydroxytryptamine receptor 2Atarget
DB00334OlanzapineDopamine D4 receptortarget
DB00334OlanzapineHistamine H1 receptortarget
DB00334OlanzapineMuscarinic acetylcholine receptor M4target
DB00334OlanzapineMuscarinic acetylcholine receptor M2target
DB00334OlanzapineDopamine D2 receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 2Ctarget
DB00334OlanzapineDopamine D3 receptortarget
DB00334OlanzapineAlpha-1B adrenergic receptortarget
DB00334OlanzapineCytochrome P450 1A2enzyme
DB00334Olanzapine5-hydroxytryptamine receptor 3Atarget
DB00334Olanzapine5-hydroxytryptamine receptor 6target
DB00334OlanzapineAlpha-1A adrenergic receptortarget
DB00334OlanzapineDopamine D5 receptortarget
DB00334OlanzapineSerum albumincarrier
DB00334OlanzapineAlpha-1-acid glycoprotein 1carrier
DB00334OlanzapineDimethylaniline monooxygenase [N-oxide-forming] 3enzyme
DB00334OlanzapineCytochrome P450 2D6enzyme
DB00334OlanzapineP-glycoprotein 1transporter
DB00334OlanzapineCytochrome P450 2C19enzyme
DB00334OlanzapineD(1) dopamine receptortarget
DB00334OlanzapineBeta adrenergic receptortarget
DB00334Olanzapine5-hydroxytryptamine receptor 1target
DB00334OlanzapineGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00334OlanzapineCytochrome P450 2C9enzyme
DB00334OlanzapineUDP-glucuronosyltransferase 1-4enzyme
DB00334OlanzapineCytochrome P450 3A4enzyme
DB00334OlanzapineCytochrome P450 3A Subfamilyenzyme
DB01224Quetiapine5-hydroxytryptamine receptor 2Atarget
DB01224Quetiapine5-hydroxytryptamine receptor 2Ctarget
DB01224QuetiapineDopamine D2 receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Atarget
DB01224QuetiapineHistamine H1 receptortarget
DB01224QuetiapineCytochrome P450 3A4enzyme
DB01224QuetiapineAlpha-1 adrenergic receptorstarget
DB01224QuetiapineAlpha-2A adrenergic receptortarget
DB01224QuetiapineAlpha-2B adrenergic receptortarget
DB01224QuetiapineAlpha-2C adrenergic receptortarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Dtarget
DB01224QuetiapineMuscarinic acetylcholine receptor M1target
DB01224QuetiapineMuscarinic acetylcholine receptor M2target
DB01224QuetiapineMuscarinic acetylcholine receptor M3target
DB01224QuetiapineMuscarinic acetylcholine receptor M4target
DB01224QuetiapineMuscarinic acetylcholine receptor M5target
DB01224Quetiapine5-hydroxytryptamine receptor 1Btarget
DB01224Quetiapine5-hydroxytryptamine receptor 1Etarget
DB01224Quetiapine5-hydroxytryptamine receptor 3Atarget
DB01224Quetiapine5-hydroxytryptamine receptor 6target
DB01224Quetiapine5-hydroxytryptamine receptor 7target
DB01224QuetiapineDopamine D5 receptortarget
DB01224QuetiapineDopamine D1 receptortarget
DB01224QuetiapineDopamine D3 receptortarget
DB01224QuetiapineDopamine D4 receptortarget
DB01224QuetiapineCytochrome P450 3A5enzyme
DB01224QuetiapineP-glycoprotein 1transporter
DB01224QuetiapineCytochrome P450 2C19enzyme
DB01224QuetiapineCytochrome P450 2D6enzyme
DB01224QuetiapineCytochrome P450 3A7enzyme
DB00734RisperidoneCytochrome P450 2D6enzyme
DB00734RisperidoneCytochrome P450 3A4enzyme
DB00734RisperidoneP-glycoprotein 1transporter
DB00734RisperidoneSerum albumincarrier
DB00734RisperidoneAlpha-1-acid glycoprotein 1carrier
DB00734Risperidone5-hydroxytryptamine receptor 2Atarget
DB00734RisperidoneDopamine D2 receptortarget
DB00734RisperidoneAlpha-1B adrenergic receptortarget
DB00734RisperidoneAlpha-2B adrenergic receptortarget
DB00734RisperidoneAlpha-1A adrenergic receptortarget
DB00734RisperidoneAlpha-2C adrenergic receptortarget
DB00734RisperidoneHistamine H1 receptortarget
DB00734Risperidone5-hydroxytryptamine receptor 2Ctarget
DB00734Risperidone5-hydroxytryptamine receptor 1Dtarget
DB00734Risperidone5-hydroxytryptamine receptor 1Atarget
DB00734Risperidone5-hydroxytryptamine receptor 7target
DB00734RisperidoneD(2L) dopamine receptortarget
DB00734RisperidoneDopamine D1 receptortarget
DB12543SamidorphanMu-type opioid receptortarget
DB12543SamidorphanKappa-type opioid receptortarget
DB12543SamidorphanDelta-type opioid receptortarget
DB12543SamidorphanCytochrome P450 3A4enzyme
DB12543SamidorphanCytochrome P450 3A5enzyme
DB12543SamidorphanCytochrome P450 2C19enzyme
DB12543SamidorphanCytochrome P450 2C8enzyme
DB00246ZiprasidoneAlpha-1A adrenergic receptortarget
DB00246ZiprasidoneDopamine D2 receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 2Ctarget
DB00246ZiprasidoneDopamine D3 receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 1Atarget
DB00246Ziprasidone5-hydroxytryptamine receptor 1Dtarget
DB00246ZiprasidoneHistamine H1 receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 2Atarget
DB00246ZiprasidoneDopamine D4 receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 7target
DB00246ZiprasidoneCytochrome P450 3A4enzyme
DB00246ZiprasidoneAlpha-2A adrenergic receptortarget
DB00246ZiprasidoneAlpha-1B adrenergic receptortarget
DB00246ZiprasidoneAlpha-2B adrenergic receptortarget
DB00246ZiprasidoneAlpha-2C adrenergic receptortarget
DB00246ZiprasidoneDopamine D1 receptortarget
DB00246ZiprasidoneDopamine D5 receptortarget
DB00246ZiprasidoneMuscarinic acetylcholine receptor M1target
DB00246ZiprasidoneMuscarinic acetylcholine receptor M2target
DB00246ZiprasidoneMuscarinic acetylcholine receptor M3target
DB00246ZiprasidoneMuscarinic acetylcholine receptor M4target
DB00246ZiprasidoneMuscarinic acetylcholine receptor M5target
DB00246Ziprasidone5-hydroxytryptamine receptor 1Btarget
DB00246Ziprasidone5-hydroxytryptamine receptor 1Etarget
DB00246Ziprasidone5-hydroxytryptamine receptor 6target
DB00246ZiprasidoneAldehyde oxidaseenzyme
DB00246ZiprasidoneSerum albumincarrier
DB00246ZiprasidoneP-glycoprotein 1transporter
DB00246ZiprasidoneAlpha-1-acid glycoprotein 1carrier
DB00246Ziprasidone5-hydroxytryptamine 3 receptortarget
DB00246Ziprasidone5-hydroxytryptamine receptor 5Atarget
DrugDrug NamePhaseStatusCount
DB01221Ketamine0Completed1
DB00683Midazolam0Completed1
DB01238Aripiprazole1Completed1
DB06216Asenapine1Completed1
DB09128Brexpiprazole1Completed1
DB00633Dexmedetomidine1Recruiting1
DB04946Iloperidone1Completed1
DB01221Ketamine1Active Not Recruiting1
DB01238Aripiprazole1 / 2Completed1
DB01238Aripiprazole2Completed1
DB01238Aripiprazole2Withdrawn1
DB06698Betahistine2Completed1
DB04888Bifeprunox2Completed1
DB09119Eslicarbazepine acetate2Completed2
DB09119Eslicarbazepine acetate2Terminated1
DB00996Gabapentin2Completed1
DB00996Gabapentin2Not Yet Recruiting1
DB00030Insulin human2Recruiting1
DB00555Lamotrigine2Terminated1
DB08815Lurasidone2Completed1
DB00184Nicotine2Completed1
DB00313Valproic acid2Terminated1
DB15490Zuranolone2Completed1
DB11931scyllo-inositol2Terminated1
DB01238Aripiprazole3Completed9
DB01238Aripiprazole3Terminated1
DB06216Asenapine3Completed3
DB09128Brexpiprazole3Completed3
DB01156Bupropion3Completed1
DB06016Cariprazine3Active Not Recruiting1
DB06016Cariprazine3Completed2
DB06016Cariprazine3Recruiting3
DB01175Escitalopram3Completed1
DB04946Iloperidone3Recruiting1
DB14509Lithium carbonate3Completed3
DB00408Loxapine3Completed1
DB08815Lurasidone3Completed4
DB00334Olanzapine3Active Not Recruiting1
DB00334Olanzapine3Completed3
DB01224Quetiapine3Completed5
DB01224Quetiapine3Terminated1
DB00734Risperidone3Completed2
DB00734Risperidone3Terminated1
DB00313Valproic acid3Completed4
DB00246Ziprasidone3Completed1
DB01238Aripiprazole4Terminated1
DB01238Aripiprazole4Unknown Status1
DB00564Carbamazepine4Completed2
DB00363Clozapine4Not Yet Recruiting1
DB00555Lamotrigine4Completed1
DB14509Lithium carbonate4Completed2
DB14509Lithium carbonate4Unknown Status2
DB14509Lithium carbonate4Withdrawn1
DB08815Lurasidone4Withdrawn1
DB00334Olanzapine4Completed2
DB01224Quetiapine4Completed1
DB00734Risperidone4Not Yet Recruiting1
DB00313Valproic acid4Completed3
DB01238AripiprazoleNot AvailableNot Yet Recruiting1
DB01238AripiprazoleNot AvailableRecruiting1
DB11695CarnosineNot AvailableCompleted1
DB14509Lithium carbonateNot AvailableNot Yet Recruiting1
DB01224QuetiapineNot AvailableCompleted2