Refractory seizure disorders

Also known as: Status-epilepticus / Status Epilepticus / Prolonged seizure / Grand mal status (disorder) / (Grand mal status) or (status epilepticus) / [X]Status epilepticus, unspecified / [X]Status epilepticus, unspecified (disorder)

DrugDrug NameDrug Description
DB00829DiazepamA long-acting benzodiazepine with rapid onset commonly used to treat panic disorders, severe anxiety, alcohol withdrawal, and seizures.
DB00949FelbamateAn anticonvulsant used to treat severe epilepsy.
DB01320FosphenytoinAn antiepileptic agent used for the management of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery.
DB06218LacosamideAn antiepileptic drug used to treat partial onset seizures in adults.
DB00186LorazepamA short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.
DB00683MidazolamA short-acting injectable benzodiazepine with rapid onset that is commonly used in seizures, anesthesia and anxiety disorders.
DrugDrug NameTargetType
DB00829DiazepamCytochrome P450 3A4enzyme
DB00829DiazepamSerum albumincarrier
DB00829DiazepamCytochrome P450 2C9enzyme
DB00829DiazepamCytochrome P450 2C19enzyme
DB00829DiazepamCytochrome P450 3A5enzyme
DB00829DiazepamCytochrome P450 3A7enzyme
DB00829DiazepamP-glycoprotein 1transporter
DB00829DiazepamCytochrome P450 2B6enzyme
DB00829DiazepamProstaglandin G/H synthase 1enzyme
DB00829DiazepamCytochrome P450 2C18enzyme
DB00829DiazepamCytochrome P450 2C8enzyme
DB00829DiazepamCytochrome P450 2E1enzyme
DB00829DiazepamGABA(A) Receptortarget
DB00829DiazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00949FelbamateGlutamate receptor ionotropic, NMDA 2Btarget
DB00949FelbamateGlutamate receptor ionotropic, NMDA 2Atarget
DB00949FelbamateCytochrome P450 2C19enzyme
DB00949FelbamateCytochrome P450 3A4enzyme
DB00949FelbamateCytochrome P450 2E1enzyme
DB00949FelbamateCytochrome P450 2C9enzyme
DB01320FosphenytoinSodium channel protein type 5 subunit alphatarget
DB01320FosphenytoinCytochrome P450 2C19enzyme
DB01320FosphenytoinCytochrome P450 2B6enzyme
DB01320FosphenytoinCytochrome P450 2C9enzyme
DB01320FosphenytoinCytochrome P450 3A4enzyme
DB01320FosphenytoinSerum albumincarrier
DB01320FosphenytoinCytochrome P450 1A2enzyme
DB01320FosphenytoinUDP-glucuronosyltransferase 1-6enzyme
DB01320FosphenytoinUDP-glucuronosyltransferase 1-9enzyme
DB01320FosphenytoinThyroxine-binding globulincarrier
DB06218LacosamideSodium channel protein type 9 subunit alphatarget
DB06218LacosamideSodium channel protein type 3 subunit alphatarget
DB06218LacosamideSodium channel protein type 10 subunit alphatarget
DB06218LacosamideCytochrome P450 2C19enzyme
DB06218LacosamideCytochrome P450 2C9enzyme
DB06218LacosamideCytochrome P450 3A4enzyme
DB00186LorazepamUDP-glucuronosyltransferase 2B15enzyme
DB00186LorazepamGABA(A) Receptortarget
DB00186LorazepamCytochrome P450 3A4enzyme
DB00186LorazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00683MidazolamCytochrome P450 3A4enzyme
DB00683MidazolamCytochrome P450 3A5enzyme
DB00683MidazolamUDP-glucuronosyltransferase 1-4enzyme
DB00683MidazolamCytochrome P450 3A7enzyme
DB00683MidazolamGABA(A) Receptortarget
DB00683MidazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DrugDrug NamePhaseStatusCount
DB00186Lorazepam1Completed1
DB00683Midazolam1Not Yet Recruiting1
DB05087Ganaxolone2Completed1
DB01202Levetiracetam2Recruiting1
DB01202Levetiracetam2Unknown Status1
DB00683Midazolam2Recruiting1
DB11062Octisalate2Completed1
DB09535Octocrylene2Completed1
DB09321Zinc oxide2Completed1
DB00829Diazepam2 / 3Completed1
DB00186Lorazepam2 / 3Completed1
DB01068Clonazepam3Completed1
DB00829Diazepam3Completed1
DB01320Fosphenytoin3Completed1
DB05087Ganaxolone3Recruiting1
DB01221Ketamine3Terminated1
DB01221Ketamine3Withdrawn1
DB06218Lacosamide3Withdrawn1
DB01202Levetiracetam3Withdrawn1
DB00186Lorazepam3Completed6
DB00186Lorazepam3Terminated1
DB11062Octisalate3Completed1
DB11062Octisalate3Recruiting1
DB09535Octocrylene3Completed1
DB09535Octocrylene3Recruiting1
DB09117Paraldehyde3Completed1
DB00312Pentobarbital3Terminated1
DB01174Phenobarbital3Withdrawn1
DB00818Propofol3Terminated1
DB00599Thiopental3Terminated1
DB09321Zinc oxide3Completed1
DB09321Zinc oxide3Recruiting1
DB01202LevetiracetamNot AvailableActive Not Recruiting1
DB00186LorazepamNot AvailableActive Not Recruiting1
DB00186LorazepamNot AvailableRecruiting1
DB00683MidazolamNot AvailableActive Not Recruiting1
DB00818PropofolNot AvailableActive Not Recruiting1
DB00599ThiopentalNot AvailableActive Not Recruiting1
DB00313Valproic acidNot AvailableActive Not Recruiting1
DB00313Valproic acidNot AvailableUnknown Status1