Lennox-Gastaut Syndrome (LGS)

Also known as: Lennox-Gastaut syndrome / Lennox Gastaut Syndrome

DrugDrug NameDrug Description
DB00349ClobazamA benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
DB01068ClonazepamA long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures.
DB00555LamotrigineA phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
DB06201RufinamideAn antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS).
DB00273TopiramateAn anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
DrugDrug NameTargetType
DB00349ClobazamCytochrome P450 2C19enzyme
DB00349ClobazamCytochrome P450 3A4enzyme
DB00349ClobazamCytochrome P450 2B6enzyme
DB00349ClobazamCytochrome P450 2C18enzyme
DB00349ClobazamSodium- and chloride-dependent GABA transporter 1transporter
DB00349ClobazamSodium- and chloride-dependent GABA transporter 3transporter
DB00349ClobazamP-glycoprotein 1transporter
DB00349ClobazamGABA(A) Receptortarget
DB00349ClobazamCytochrome P450 2D6enzyme
DB00349ClobazamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB01068ClonazepamCytochrome P450 3A4enzyme
DB01068ClonazepamSerum albumincarrier
DB01068ClonazepamCytochrome P450 2E1enzyme
DB01068ClonazepamArylamine N-acetyltransferase 2enzyme
DB01068ClonazepamGABA(A) Receptortarget
DB01068ClonazepamNuclear receptor subfamily 1 group I member 2target
DB01068ClonazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00555LamotrigineVoltage-gated sodium channel alpha subunittarget
DB00555LamotrigineUDP-glucuronosyltransferases (UGTs)enzyme
DB00555LamotrigineP-glycoprotein 1transporter
DB00555LamotrigineDihydrofolate reductaseenzyme
DB00555Lamotrigine5-hydroxytryptamine receptor 3Atarget
DB00555LamotrigineVoltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)target
DB00555LamotrigineAdenosine receptor A1target
DB00555LamotrigineAdenosine receptor A2atarget
DB00555LamotrigineAlpha-1A adrenergic receptortarget
DB00555LamotrigineAlpha-2A adrenergic receptortarget
DB00555LamotrigineBeta-1 adrenergic receptortarget
DB00555LamotrigineD(1) dopamine receptortarget
DB00555LamotrigineDopamine D2 receptortarget
DB00555LamotrigineGABA(A) Receptortarget
DB00555LamotrigineGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00555LamotrigineHistamine H1 receptortarget
DB00555LamotrigineKappa-type opioid receptortarget
DB00555LamotrigineAcetylcholine receptor subunit alphatarget
DB00555Lamotrigine5-hydroxytryptamine receptor 2Atarget
DB00555LamotrigineSolute carrier family 22 member 2transporter
DB00555LamotrigineSerum albumincarrier
DB00555LamotrigineSolute carrier family 22 member 1transporter
DB00555LamotrigineGlutamate receptor 1target
DB06201RufinamideMetabotropic glutamate receptor 5target
DB06201RufinamideLiver carboxylesterase 1enzyme
DB06201RufinamideSodium channel protein type 9 subunit alphatarget
DB06201RufinamideSerum albumincarrier
DB06201RufinamideCytochrome P450 2E1enzyme
DB06201RufinamideCytochrome P450 3A4enzyme
DB00273TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
DB00273TopiramateVoltage-gated sodium channel alpha subunittarget
DB00273TopiramateCarbonic anhydrase 2target
DB00273TopiramateCarbonic anhydrase 4target
DB00273TopiramateKainate receptorstarget
DB00273TopiramateCytochrome P450 2C19enzyme
DB00273TopiramateCytochrome P450 3A4enzyme
DB00273TopiramateCarbonic anhydrase 1target
DB00273TopiramateCarbonic anhydrase 3target
DB00273TopiramateVoltage gated L-type calcium channeltarget
DB00273TopiramateVoltage-dependent R-type calcium channeltarget
DB00273TopiramateSerum albumincarrier
DB00273TopiramateP-glycoprotein 1transporter
DB00273Topiramate5'-AMP-activated protein kinasetransporter
DrugDrug NamePhaseStatusCount
DB12338Carisbamate1Recruiting2
DB09061Cannabidiol1 / 2Terminated1
DB00574Fenfluramine1 / 2Active Not Recruiting1
DB00574Fenfluramine2Active Not Recruiting1
DB09061Cannabidiol3Completed3
DB09061Cannabidiol3Recruiting1
DB09061Cannabidiol3Withdrawn1
DB00349Clobazam3Completed1
DB00574Fenfluramine3Enrolling by Invitation1
DB00574Fenfluramine3Recruiting1
DB00334Olanzapine3Completed1
DB08883Perampanel3Recruiting1
DB06201Rufinamide3Completed3
DB00273Topiramate3Completed1
DB09061Cannabidiol4Withdrawn1
DB01065Melatonin4Unknown Status1
DB08883PerampanelNot AvailableAvailable1
DB06201RufinamideNot AvailableAvailable1
DB06201RufinamideNot AvailableRecruiting1