Itching

Also known as: ITCH / Pruritus / Pruritus NOS / Pruritis / Unspecified pruritic disorder / Pruritus cutaneous / Itchy skin / Itchy

DrugDrug NameDrug Description
DB04890BepotastineAn ophthalmic H1 antagonist used to treat itchiness associated with allergic conjunctivitis.
DB00443BetamethasoneA systemic corticosteroid used to relieve inflammation in various conditions, including but not limited to allergic states, dermatologic disorders, gastrointestinal diseases, and hematological disorders.
DB01222BudesonideA corticosteroid used to treat Crohn's disease, asthma, COPD, hay fever and allergies, and ulcerative colitis.
DB14256Centella asiaticaCentella asiatica is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.
DB01718CetrimoniumA compound that can be used as a topical antiseptic.
DB01114ChlorpheniramineA histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.
DB09357DexpanthenolAn alcoholic analogue of D-pantothenic acid that is used as a supplement or application to support a healthy epithelium and is also used to prevent vitamin deficiency in patients receiving total parenteral nutrition (TPN).
DB01075DiphenhydramineA H1 receptor antihistamine used in the treatment of seasonal allergies, and various allergic reactions including sneezing, runny nose, itchy/watery eyes, itching of nose or throat, pruritus, urticaria, insect bites/stings, and allergic rashes.
DB00196FluconazoleA triazole antifungal used to treat various fungal infections including candidiasis.
DB00591Fluocinolone acetonideA corticosteroid used to treat skin conditions, eczematous otitis externa, diabetic macular edema, and non-infectious uveitis of the posterior segment of the eye.
DB08818Hyaluronic acidA glycosaminoglycan used for the relief of joint pain, wound healing, ophthalmologic treatment, cosmetic treatment, and various other applications.
DB14539Hydrocortisone acetateA corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses and ulcerative colitis.
DB14543Hydrocortisone probutateA corticosteroid used to treat inflammatory and pruritic corticosteroid-responsive dermatoses.
DB00455LoratadineA second generation antihistamine used to manage the symptoms of allergic rhinitis.
DB15840Pine tarA medication indicated in itchy, inflamed, and flaky skin conditions.
DB00860PrednisoloneA glucocorticoid used to treat adrenocortical insufficiency, inflammatory conditions, and some cancers.
DB00936Salicylic acidAn acid used to treat acne, psoriasis, calluses, corns, keratosis pilaris, and warts.
DB14156Synthetic camphorNot Annotated
DB14487Zinc acetateA medication used to treat zinc deficiency.
DB09321Zinc oxideA mineral ingredient of various pharmacological preparations to treat diaper dermatitis and other skin conditions, to protect the epidermis, and to prevent sunburn.
DrugDrug NameTargetType
DB04890BepotastineHistamine H1 receptortarget
DB00443BetamethasoneGlucocorticoid receptortarget
DB00443BetamethasoneCytochrome P450 3A4enzyme
DB00443BetamethasoneP-glycoprotein 1transporter
DB00443BetamethasoneCytochrome P450 19A1enzyme
DB00443BetamethasoneCytochrome P450 3A5enzyme
DB00443BetamethasoneCytochrome P450 3A7enzyme
DB00443BetamethasoneCytochrome P450 2A6enzyme
DB00443BetamethasoneCytochrome P450 1B1enzyme
DB00443BetamethasoneCytochrome P450 2B6enzyme
DB00443BetamethasoneCytochrome P450 2C8enzyme
DB00443BetamethasoneCytochrome P450 2C9enzyme
DB00443BetamethasoneCytochrome P450 2C19enzyme
DB00443BetamethasoneSerum albumincarrier
DB00443BetamethasoneCorticosteroid-binding globulincarrier
DB01222BudesonideGlucocorticoid receptortarget
DB01222BudesonideCytochrome P450 3A4enzyme
DB01222BudesonideCytochrome P450 3A5enzyme
DB01222BudesonideBile salt export pumptransporter
DB01222BudesonideP-glycoprotein 1transporter
DB01222BudesonideAnnexin A1target
DB01222BudesonideCytochrome P450 3A Subfamilyenzyme
DB01222BudesonideCytochrome P450 2A6enzyme
DB01222BudesonideCytochrome P450 1B1enzyme
DB01222BudesonideCytochrome P450 2B6enzyme
DB01222BudesonideCytochrome P450 2C8enzyme
DB01222BudesonideCytochrome P450 2C9enzyme
DB01222BudesonideCytochrome P450 2C19enzyme
DB01222BudesonideCorticosteroid-binding globulincarrier
DB01222BudesonideSolute carrier organic anion transporter family member 1A2transporter
DB01222BudesonideSolute carrier family 22 member 8transporter
DB01222BudesonideSerum albumincarrier
DB01718CetrimoniumCyclopropane mycolic acid synthase MmaA2target
DB01718CetrimoniumCyclopropane mycolic acid synthase 1target
DB01114ChlorpheniramineHistamine H1 receptortarget
DB01114ChlorpheniramineCytochrome P450 3A4enzyme
DB01114ChlorpheniramineCytochrome P450 2D6enzyme
DB01114ChlorpheniramineSodium-dependent serotonin transportertarget
DB01114ChlorpheniramineSodium-dependent noradrenaline transportertarget
DB01114ChlorpheniramineSodium-dependent dopamine transportertarget
DB01114ChlorpheniramineCytochrome P450 3A5enzyme
DB01114ChlorpheniramineCytochrome P450 3A7enzyme
DB01114ChlorpheniramineSolute carrier family 22 member 2transporter
DB01114ChlorpheniramineSolute carrier family 22 member 1transporter
DB01075DiphenhydramineHistamine H1 receptortarget
DB01075DiphenhydramineCytochrome P450 2D6enzyme
DB01075DiphenhydramineCytochrome P450 2C9enzyme
DB01075DiphenhydramineCytochrome P450 2C19enzyme
DB01075DiphenhydramineSolute carrier family 22 member 2transporter
DB01075DiphenhydramineSolute carrier family 22 member 5transporter
DB01075DiphenhydramineProstaglandin G/H synthase 1enzyme
DB01075DiphenhydramineMuscarinic acetylcholine receptor M2target
DB00196FluconazoleCytochrome P450 3A4enzyme
DB00196FluconazoleCytochrome P450 2C9enzyme
DB00196FluconazoleCytochrome P450 2C19enzyme
DB00196FluconazoleP-glycoprotein 1transporter
DB00196FluconazoleCytochrome P450 51target
DB00196FluconazoleCytochrome P450 3A5enzyme
DB00591Fluocinolone acetonideCorticosteroid-binding globulincarrier
DB00591Fluocinolone acetonideGlucocorticoid receptortarget
DB00591Fluocinolone acetonideCytochrome P450 3A4enzyme
DB00591Fluocinolone acetonideAnnexin A1target
DB00591Fluocinolone acetonideAnnexin A2target
DB00591Fluocinolone acetonideAnnexin A3target
DB00591Fluocinolone acetonideAnnexin A4target
DB00591Fluocinolone acetonideAnnexin A5target
DB08818Hyaluronic acidCD44 antigentarget
DB08818Hyaluronic acidIntercellular adhesion molecule 1target
DB08818Hyaluronic acidHyaluronan mediated motility receptortarget
DB08818Hyaluronic acidNeurocan core proteintarget
DB08818Hyaluronic acidVersican core proteintarget
DB08818Hyaluronic acidComplement component 1 Q subcomponent-binding protein, mitochondrialtarget
DB08818Hyaluronic acidHyaluronan and proteoglycan link protein 1target
DB08818Hyaluronic acidHyaluronan and proteoglycan link protein 3target
DB08818Hyaluronic acidHyaluronan-binding protein 2target
DB08818Hyaluronic acidLayilintarget
DB08818Hyaluronic acidStabilin-2target
DB08818Hyaluronic acidTumor necrosis factor-inducible gene 6 proteintarget
DB08818Hyaluronic acidInterphotoreceptor matrix proteoglycan 2target
DB08818Hyaluronic acidIntracellular hyaluronan-binding protein 4target
DB08818Hyaluronic acidHyaluronidase enzymesenzyme
DB08818Hyaluronic acidMultidrug resistance-associated protein 5transporter
DB08818Hyaluronic acidLymphatic vessel endothelial hyaluronic acid receptor 1target
DB14539Hydrocortisone acetateAnnexin A1target
DB14539Hydrocortisone acetateGlucocorticoid receptortarget
DB14539Hydrocortisone acetateSex hormone-binding globulincarrier
DB14539Hydrocortisone acetateCytochrome P450 3A4enzyme
DB14539Hydrocortisone acetateCytochrome P450 3A5enzyme
DB14539Hydrocortisone acetateCytochrome P450 3A7enzyme
DB14539Hydrocortisone acetateP-glycoprotein 1transporter
DB14539Hydrocortisone acetateSolute carrier organic anion transporter family member 1A2transporter
DB14539Hydrocortisone acetateATP-binding cassette sub-family G member 2transporter
DB14539Hydrocortisone acetateCytochrome P450 11B1, mitochondrialenzyme
DB14539Hydrocortisone acetateCytochrome P450 11B2, mitochondrialenzyme
DB14539Hydrocortisone acetateCytochrome P450 2C8enzyme
DB14539Hydrocortisone acetateCorticosteroid-binding globulincarrier
DB14539Hydrocortisone acetateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14539Hydrocortisone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14539Hydrocortisone acetateSolute carrier family 22 member 8transporter
DB14543Hydrocortisone probutateAnnexin A1target
DB14543Hydrocortisone probutateGlucocorticoid receptortarget
DB14543Hydrocortisone probutateSex hormone-binding globulincarrier
DB14543Hydrocortisone probutateCytochrome P450 3A4enzyme
DB14543Hydrocortisone probutateCytochrome P450 3A5enzyme
DB14543Hydrocortisone probutateCytochrome P450 3A7enzyme
DB14543Hydrocortisone probutateP-glycoprotein 1transporter
DB14543Hydrocortisone probutateSolute carrier organic anion transporter family member 1A2transporter
DB14543Hydrocortisone probutateATP-binding cassette sub-family G member 2transporter
DB14543Hydrocortisone probutateCytochrome P450 11B1, mitochondrialenzyme
DB14543Hydrocortisone probutateCytochrome P450 11B2, mitochondrialenzyme
DB14543Hydrocortisone probutateCytochrome P450 2C8enzyme
DB14543Hydrocortisone probutateCorticosteroid-binding globulincarrier
DB14543Hydrocortisone probutateCorticosteroid 11-beta-dehydrogenase isozyme 2target
DB14543Hydrocortisone probutate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1target
DB14543Hydrocortisone probutateSolute carrier family 22 member 8transporter
DB00455LoratadineHistamine H1 receptortarget
DB00455LoratadineCytochrome P450 3A4enzyme
DB00455LoratadineCytochrome P450 2C19enzyme
DB00455LoratadineCytochrome P450 2D6enzyme
DB00455LoratadineCytochrome P450 2C8enzyme
DB00455LoratadineP-glycoprotein 1transporter
DB00455LoratadinePotassium voltage-gated channel subfamily H member 2target
DB00455LoratadineBile salt export pumptransporter
DB00455LoratadineCytochrome P450 1A1enzyme
DB00455LoratadineCytochrome P450 1A2enzyme
DB00455LoratadineCytochrome P450 2B6enzyme
DB00455LoratadineCytochrome P450 2C9enzyme
DB00455LoratadineCytochrome P450 3A5enzyme
DB00455LoratadineUDP-glucuronosyltransferase 2B10enzyme
DB00455LoratadineUDP-glucuronosyltransferase 1-1enzyme
DB00455LoratadineUDP-glucuronosyltransferase 1-3enzyme
DB00455LoratadineUDP-glucuronosyltransferase 2B15enzyme
DB00860PrednisoloneCorticosteroid-binding globulincarrier
DB00860PrednisoloneCytochrome P450 3A4enzyme
DB00860PrednisoloneGlucocorticoid receptortarget
DB00860PrednisoloneSolute carrier organic anion transporter family member 1A2transporter
DB00860PrednisoloneP-glycoprotein 1transporter
DB00860PrednisoloneSerum albumincarrier
DB00936Salicylic acidSerum albumincarrier
DB00936Salicylic acidProstaglandin G/H synthase 1target
DB00936Salicylic acidProstaglandin G/H synthase 2target
DB00936Salicylic acidAldo-keto reductase family 1 member C1target
DB00936Salicylic acidSolute carrier family 22 member 6transporter
DB00936Salicylic acidSolute carrier family 22 member 10transporter
DB00936Salicylic acidSolute carrier family 22 member 8transporter
DB00936Salicylic acidSolute carrier family 22 member 11transporter
DB00936Salicylic acidSolute carrier organic anion transporter family member 2B1transporter
DB00936Salicylic acidMonocarboxylate transporter 1transporter
DB00936Salicylic acidSolute carrier family 22 member 7transporter
DB00936Salicylic acidCytochrome P450 2C9enzyme
DB14487Zinc acetateB1 bradykinin receptortarget
DB14487Zinc acetateMethylated-DNA--protein-cysteine methyltransferasetarget
DB14487Zinc acetateFructose-bisphosphate aldolase Atarget
DB14487Zinc acetateElongation factor 1-alpha 1target
DB14487Zinc acetateAlpha-enolasetarget
DB14487Zinc acetateGlyceraldehyde-3-phosphate dehydrogenase, testis-specifictarget
DB14487Zinc acetateNucleoside diphosphate kinase Atarget
DB14487Zinc acetateProtein disulfide-isomerasetarget
DB14487Zinc acetateProtein disulfide-isomerase A3target
DB14487Zinc acetatePeroxiredoxin-1target
DB14487Zinc acetatePhosphoserine phosphatasetarget
DB14487Zinc acetateTriosephosphate isomerasetarget
DB14487Zinc acetateElongation factor Tu, mitochondrialtarget
DB14487Zinc acetateEstrogen receptor alphatarget
DB14487Zinc acetateInterleukin-3target
DB14487Zinc acetateMetallothionein-2target
DB14487Zinc acetateCopper chaperone for superoxide dismutasetarget
DB14487Zinc acetateHistone deacetylase 1target
DB14487Zinc acetateHistone deacetylase 4target
DB14487Zinc acetateDNA-3-methyladenine glycosylasetarget
DB14487Zinc acetateSemenogelin-1target
DB14487Zinc acetateSuperoxide dismutase [Cu-Zn]target
DB14487Zinc acetateHistone deacetylase 8target
DB14487Zinc acetateApoptosis regulatory protein Sivatarget
DB14487Zinc acetateGlycine receptor subunit alpha-1target
DB14487Zinc acetateE3 ubiquitin-protein ligase Mdm2target
DB14487Zinc acetateInsulintarget
DB14487Zinc acetateUtrophintarget
DB14487Zinc acetateAspartoacylasetarget
DB14487Zinc acetateProtein S100-A8target
DB14487Zinc acetateProtein S100-A9target
DB14487Zinc acetateMatrix metalloproteinase-9target
DB14487Zinc acetateTumor protein p73target
DB14487Zinc acetateProtein S100-A2target
DB14487Zinc acetateCellular tumor antigen p53target
DB14487Zinc acetateMetallothionein-3target
DB14487Zinc acetateProgrammed cell death protein 6target
DB14487Zinc acetateDAN domain family member 5target
DB14487Zinc acetateMetallothionein-1Atarget
DB14487Zinc acetateAlpha-1B-glycoproteintarget
DB14487Zinc acetateAlpha-2-macroglobulintarget
DB14487Zinc acetateAngiotensinogentarget
DB14487Zinc acetateAlpha-2-HS-glycoproteintarget
DB14487Zinc acetateSerum amyloid P-componenttarget
DB14487Zinc acetateApolipoprotein A-Itarget
DB14487Zinc acetateApolipoprotein A-IItarget
DB14487Zinc acetateApolipoprotein A-IVtarget
DB14487Zinc acetateApolipoprotein B receptortarget
DB14487Zinc acetateApolipoprotein Etarget
DB14487Zinc acetateApolipoprotein L1target
DB14487Zinc acetateComplement C1q subcomponent subunit Btarget
DB14487Zinc acetateComplement C1q subcomponent subunit Ctarget
DB14487Zinc acetateComplement C1r subcomponenttarget
DB14487Zinc acetateComplement C1s subcomponenttarget
DB14487Zinc acetateComplement C3target
DB14487Zinc acetateComplement C4-Btarget
DB14487Zinc acetateC4b-binding protein alpha chaintarget
DB14487Zinc acetateC4b-binding protein beta chaintarget
DB14487Zinc acetateComplement C5target
DB14487Zinc acetateLys-63-specific deubiquitinase BRCC36target
DB14487Zinc acetateComplement component C8 alpha chaintarget
DB14487Zinc acetateComplement component C8 beta chaintarget
DB14487Zinc acetateComplement component C8 gamma chaintarget
DB14487Zinc acetateComplement factor Btarget
DB14487Zinc acetateComplement factor Htarget
DB14487Zinc acetateComplement factor Itarget
DB14487Zinc acetateClusterintarget
DB14487Zinc acetateCeruloplasmintarget
DB14487Zinc acetateCarboxypeptidase N catalytic chaintarget
DB14487Zinc acetateCarboxypeptidase N subunit 2target
DB14487Zinc acetateDermcidintarget
DB14487Zinc acetateDesmoplakintarget
DB14487Zinc acetateCoagulation factor XIItarget
DB14487Zinc acetateCoagulation factor XIII B chaintarget
DB14487Zinc acetateProthrombintarget
DB14487Zinc acetateFicolin-3target
DB14487Zinc acetateFibrinogen alpha chaintarget
DB14487Zinc acetateFibronectintarget
DB14487Zinc acetateGelsolintarget
DB14487Zinc acetateHemoglobin subunit alphatarget
DB14487Zinc acetateHemoglobin subunit betatarget
DB14487Zinc acetateHaptoglobin-related proteintarget
DB14487Zinc acetateHornerintarget
DB14487Zinc acetateInsulin-like growth factor-binding protein complex acid labile subunittarget
DB14487Zinc acetateIg alpha-1 chain C regiontarget
DB14487Zinc acetateIg mu chain C regiontarget
DB14487Zinc acetateImmunoglobulin kappa variable 1-17target
DB14487Zinc acetateIg kappa chain V-III region GOLtarget
DB14487Zinc acetateImmunoglobulin lambda variable 3-21target
DB14487Zinc acetateInter-alpha-trypsin inhibitor heavy chain H1target
DB14487Zinc acetateInter-alpha-trypsin inhibitor heavy chain H2target
DB14487Zinc acetateInter-alpha-trypsin inhibitor heavy chain H3target
DB14487Zinc acetateInter-alpha-trypsin inhibitor heavy chain H4target
DB14487Zinc acetateImmunoglobulin J chaintarget
DB14487Zinc acetateJunction plakoglobintarget
DB14487Zinc acetatePlasma kallikreintarget
DB14487Zinc acetateKininogen-1target
DB14487Zinc acetateKeratin, type II cytoskeletal 1target
DB14487Zinc acetateKeratin, type I cytoskeletal 10target
DB14487Zinc acetateKeratin, type I cytoskeletal 14target
DB14487Zinc acetateKeratin, type I cytoskeletal 16target
DB14487Zinc acetateKeratin, type II cytoskeletal 2 epidermaltarget
DB14487Zinc acetateKeratin, type II cytoskeletal 5target
DB14487Zinc acetateKeratin, type II cytoskeletal 6Atarget
DB14487Zinc acetateKeratin, type I cytoskeletal 9target
DB14487Zinc acetateAlpha-1-acid glycoprotein 2target
DB14487Zinc acetateN-acetylmuramoyl-L-alanine amidasetarget
DB14487Zinc acetateSerum paraoxonase/arylesterase 1target
DB14487Zinc acetatePregnancy zone proteintarget
DB14487Zinc acetateProtein S100-A7target
DB14487Zinc acetateSelenoprotein Ptarget
DB14487Zinc acetateAlpha-1-antitrypsintarget
DB14487Zinc acetateAlpha-1-antichymotrypsintarget
DB14487Zinc acetateKallistatintarget
DB14487Zinc acetateCorticosteroid-binding globulintarget
DB14487Zinc acetateHeparin cofactor 2target
DB14487Zinc acetateSex hormone-binding globulintarget
DB14487Zinc acetateSerotransferrintarget
DB14487Zinc acetateTransthyretintarget
DB14487Zinc acetateVitronectintarget
DB14487Zinc acetateAmyloid-like protein 1target
DB14487Zinc acetateAmyloid-like protein 2target
DB14487Zinc acetateAmyloid beta A4 proteintarget
DB14487Zinc acetatePoly [ADP-ribose] polymerase 1target
DB14487Zinc acetateCarbonic anhydrase 1enzyme
DB14487Zinc acetateCarboxypeptidase Eenzyme
DB14487Zinc acetateAlcohol dehydrogenase 1Cenzyme
DB14487Zinc acetateInsulin-degrading enzymeenzyme
DB14487Zinc acetateSuperoxide dismutase [Cu-Zn]enzyme
DrugDrug NamePhaseStatusCount
DB00240Alclometasone2Completed1
DB05676Apremilast2Completed1
DB00673Aprepitant2Completed1
DB00950Fexofenadine2Completed1
DB00635Prednisone2Completed1
DB09321Zinc oxide2Completed1
DB09061Cannabidiol2 / 3Withdrawn1
DB09321Zinc oxide2 / 3Withdrawn1
DB00996Gabapentin3Completed1
DB14512Mometasone furoate3Unknown Status1
DB00230Pregabalin3Recruiting1
DB06774CapsaicinNot AvailableRecruiting1
DB14547Chloride ionNot AvailableRecruiting1
DB01075DiphenhydramineNot AvailableCompleted1
DB01075DiphenhydramineNot AvailableRecruiting1
DB01142DoxepinNot AvailableNot Yet Recruiting2
DB01142DoxepinNot AvailableWithdrawn1
DB00813FentanylNot AvailableCompleted1
DB05381HistamineNot AvailableCompleted2
DB05381HistamineNot AvailableNot Yet Recruiting2
DB05381HistamineNot AvailableRecruiting1
DB00724ImiquimodNot AvailableWithdrawn1
DB00281LidocaineNot AvailableCompleted2
DB00281LidocaineNot AvailableNot Yet Recruiting1
DB00295MorphineNot AvailableCompleted1
DB00295MorphineNot AvailableRecruiting1
DB00904OndansetronNot AvailableCompleted1
DB11193PapainNot AvailableActive Not Recruiting1
DB11193PapainNot AvailableNot Yet Recruiting1
DB00750PrilocaineNot AvailableNot Yet Recruiting1
DB09321Zinc oxideNot AvailableWithdrawn1