Primary apnea of premature newborns

Also known as: Apneas of Prematurity / Apnea of Prematurity / Primary apnoea of premature newborns / Other apnea of newborn / Apnea of prematurity (disorder) / Infantile apnoea / Infantile apnea / Apnea of infancy (disorder)

Drug	Drug Name	Drug Description
DB00201	Caffeine	A stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. It is also used in to prevent and treat pulmonary complications of premature birth.

Drug	Drug Name	Target	Type
DB00201	Caffeine	Adenosine receptor A1	target
DB00201	Caffeine	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	target
DB00201	Caffeine	Adenosine receptor A2a	target
DB00201	Caffeine	Cytochrome P450 1A2	enzyme
DB00201	Caffeine	Ryanodine receptor 1	target
DB00201	Caffeine	Cytochrome P450 3A4	enzyme
DB00201	Caffeine	Cytochrome P450 2E1	enzyme
DB00201	Caffeine	Cytochrome P450 2C8	enzyme
DB00201	Caffeine	Cytochrome P450 2C9	enzyme
DB00201	Caffeine	Cytochrome P450 1A1	enzyme
DB00201	Caffeine	Cytochrome P450 1B1	enzyme
DB00201	Caffeine	Cytochrome P450 2D6	enzyme
DB00201	Caffeine	Cyclic nucleotide phosphodiesterase	target
DB00201	Caffeine	DNA-dependent protein kinase catalytic subunit	target
DB00201	Caffeine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	target
DB00201	Caffeine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	target
DB00201	Caffeine	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	target
DB00201	Caffeine	Inositol 1,4,5-trisphosphate receptor	target
DB00201	Caffeine	Serine-protein kinase ATM	target
DB00201	Caffeine	ATP-binding cassette sub-family G member 2	transporter
DB00201	Caffeine	Adenosine receptor A2b	target
DB00201	Caffeine	Adenosine receptor A3	target
DB00201	Caffeine	Phosphodiesterase enzymes	target

Drug	Drug Name	Phase	Status	Count
DB00201	Caffeine	1	Unknown Status	1
DB00201	Caffeine	2	Recruiting	1
DB00277	Theophylline	2 / 3	Completed	1
DB00201	Caffeine	3	Active Not Recruiting	1
DB00201	Caffeine	3	Completed	3
DB00561	Doxapram	3	Recruiting	1
DB00201	Caffeine	4	Active Not Recruiting	1
DB00201	Caffeine	4	Completed	2
DB00201	Caffeine	Not Available	Completed	2
DB00201	Caffeine	Not Available	Terminated	1
DB00201	Caffeine	Not Available	Unknown Status	1
DB09140	Oxygen	Not Available	Unknown Status	1