Refractory, metastatic hormone-refractory Prostate cancer

Also known as: Metastatic Prostate Carcinoma / Prostate Cancer Metastatic / Metastatic Prostate Cancer / Metastatic Hormone Refractory Prostate Cancer / Carcinoma of the prostate metastatic / Prostatic cancer metastatic

DrugDrug NameDrug Description
DB06772CabazitaxelAn antineoplastic agent used for the treatment of hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen.
DB04839Cyproterone acetateA steroid used in combination with ethinyl estradiol to treat women with severe acne and symptoms of androgenization. Also used alone at much higher doses for palliative treatment of patients with prostate cancer
DB01248DocetaxelA taxoid antineoplastic agent used in the treatment of various cancers, such as locally advanced or metastatic breast cancer, metastatic prostate cancer, gastric adenocarcinoma, and head and neck cancer.
DB01196EstramustineAn antineoplastic agent used for the management of metastatic and/or progressive prostate cancer in palliative setting.
DB00665NilutamideAn antineoplastic hormone used to treat prostate cancer.
DrugDrug NameTargetType
DB06772CabazitaxelCytochrome P450 3A4enzyme
DB06772CabazitaxelCytochrome P450 3A5enzyme
DB06772CabazitaxelCytochrome P450 2C8enzyme
DB06772CabazitaxelP-glycoprotein 1transporter
DB06772CabazitaxelATP-binding cassette sub-family G member 2transporter
DB06772CabazitaxelTubulin alpha-4A chaintarget
DB06772CabazitaxelTubulin beta-1 chaintarget
DB06772CabazitaxelSolute carrier organic anion transporter family member 1B1transporter
DB06772CabazitaxelSolute carrier organic anion transporter family member 1B3transporter
DB04839Cyproterone acetateAndrogen receptortarget
DB04839Cyproterone acetateProstate-specific antigentarget
DB04839Cyproterone acetateCytochrome P450 3A4enzyme
DB04839Cyproterone acetateCytochrome P450 19A1enzyme
DB01248DocetaxelApoptosis regulator Bcl-2target
DB01248DocetaxelTubulin beta-1 chaintarget
DB01248DocetaxelCytochrome P450 3A4enzyme
DB01248DocetaxelCytochrome P450 3A5enzyme
DB01248DocetaxelCytochrome P450 3A7enzyme
DB01248DocetaxelP-glycoprotein 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 7transporter
DB01248DocetaxelCytochrome P450 1B1enzyme
DB01248DocetaxelMicrotubule-associated protein 2target
DB01248DocetaxelMicrotubule-associated protein 4target
DB01248DocetaxelMicrotubule-associated protein tautarget
DB01248DocetaxelSolute carrier organic anion transporter family member 1B3transporter
DB01248DocetaxelSolute carrier family 22 member 7transporter
DB01248DocetaxelATP-binding cassette sub-family G member 2transporter
DB01248DocetaxelCanalicular multispecific organic anion transporter 1transporter
DB01248DocetaxelMultidrug resistance-associated protein 1transporter
DB01248DocetaxelNuclear receptor subfamily 1 group I member 2target
DB01196EstramustineEstrogen receptor betatarget
DB01196EstramustineEstrogen receptor alphatarget
DB01196EstramustineMicrotubule-associated protein 2target
DB01196EstramustineMicrotubule-associated protein 1Atarget
DB01196EstramustineP-glycoprotein 1transporter
DB01196EstramustineCytochrome P450 3A4enzyme
DB00665NilutamideAndrogen receptortarget
DB00665NilutamideCytochrome P450 2C19enzyme
DB00665NilutamideNADPH--cytochrome P450 reductaseenzyme
DrugDrug NamePhaseStatusCount
DB15029AZD-81861Recruiting1
DB05812Abiraterone1Active Not Recruiting1
DB05812Abiraterone1Recruiting1
DB11901Apalutamide1Active Not Recruiting1
DB11595Atezolizumab1Completed1
DB01128Bicalutamide1Completed1
DB06772Cabazitaxel1Withdrawn1
DB08875Cabozantinib1Recruiting2
DB00531Cyclophosphamide1Completed1
DB00531Cyclophosphamide1Recruiting1
DB01248Docetaxel1Active Not Recruiting1
DB01248Docetaxel1Completed1
DB01248Docetaxel1Recruiting1
DB05094Enzalutamide1Completed1
DB08899Enzalutamide1Completed1
DB05094Enzalutamide1Recruiting1
DB08899Enzalutamide1Recruiting1
DB08899Enzalutamide1Terminated1
DB01073Fludarabine1Recruiting1
DB09150Fludeoxyglucose (18F)1Terminated1
DB09502Fludeoxyglucose (18F)1Terminated1
DB09398Fluoride ion F-181Completed1
DB09398Fluoride ion F-181Terminated1
DB13134Fluorine F-181Terminated1
DB13034Foxy-51Completed1
DB16019Gallium Ga-68 gozetotide1Recruiting1
DB16303Gallium-68 PSMA1Recruiting1
DB06186Ipilimumab1Recruiting1
DB00007Leuprolide1Completed1
DB13982Lutetium Lu-1771Not Yet Recruiting1
DB13982Lutetium Lu-1771Recruiting1
DB13982Lutetium Lu-1771Unknown Status1
DB15306MEDI-64691Completed1
DB06803Niclosamide1Completed1
DB06803Niclosamide1Recruiting1
DB11793Niraparib1Terminated1
DB09035Nivolumab1Recruiting2
DB09330Osimertinib1Recruiting1
DB09037Pembrolizumab1Recruiting2
DB14805Piflufolastat F 181Completed2
DB00635Prednisone1Active Not Recruiting1
DB00635Prednisone1Recruiting1
DB15185Rasdegafusp alfa1Completed1
DB06688Sipuleucel-T1Completed1
DB00877Sirolimus1Completed1
DB11760Talazoparib1Recruiting1
DB12887Tazemetostat1Recruiting1
DB03904Urea1Recruiting1
DB00399Zoledronic acid1Completed1
DB05812Abiraterone1 / 2Recruiting1
DB05812Abiraterone1 / 2Unknown Status1
DB11595Atezolizumab1 / 2Recruiting1
DB11945Avelumab1 / 2Recruiting2
DB06772Cabazitaxel1 / 2Active Not Recruiting1
DB06772Cabazitaxel1 / 2Completed1
DB00958Carboplatin1 / 2Completed1
DB00958Carboplatin1 / 2Terminated1
DB14681Cortisone1 / 2Active Not Recruiting1
DB14772DCFBC F-181 / 2Completed1
DB01254Dasatinib1 / 2Completed1
DB01248Docetaxel1 / 2Completed1
DB01248Docetaxel1 / 2Terminated1
DB08899Enzalutamide1 / 2Active Not Recruiting1
DB05094Enzalutamide1 / 2Recruiting2
DB08899Enzalutamide1 / 2Recruiting4
DB11717Epacadostat1 / 2Recruiting1
DB16479Inbakicept1 / 2Recruiting1
DB00328Indomethacin1 / 2Recruiting1
DB11743Ipatasertib1 / 2Recruiting1
DB16208Ivuxolimab1 / 2Recruiting1
DB00959Methylprednisolone1 / 2Active Not Recruiting1
DB16252Nedisertib1 / 2Recruiting1
DB12637Onapristone1 / 2Unknown Status1
DB09037Pembrolizumab1 / 2Active Not Recruiting1
DB00635Prednisone1 / 2Active Not Recruiting1
DB00635Prednisone1 / 2Recruiting1
DB11730Ribociclib1 / 2Recruiting1
DB04974Rimiducid1 / 2Recruiting1
DB00877Sirolimus1 / 2Terminated1
DB11760Talazoparib1 / 2Recruiting1
DB12887Tazemetostat1 / 2Recruiting1
DB00853Temozolomide1 / 2Recruiting1
DB15113Utomilumab1 / 2Recruiting1
DB11581Venetoclax1 / 2Recruiting1
DB05812Abiraterone2Active Not Recruiting1
DB05812Abiraterone2Completed5
DB05812Abiraterone2Not Yet Recruiting2
DB05812Abiraterone2Recruiting8
DB05812Abiraterone2Terminated1
DB12775Abituzumab2Completed1
DB11901Apalutamide2Active Not Recruiting1
DB11901Apalutamide2Recruiting2
DB11901Apalutamide2Withdrawn1
DB11595Atezolizumab2Recruiting1
DB11794Berzosertib2Active Not Recruiting1
DB00112Bevacizumab2Completed1
DB06772Cabazitaxel2Active Not Recruiting2
DB06772Cabazitaxel2Completed1
DB06772Cabazitaxel2Recruiting3
DB06772Cabazitaxel2Terminated1
DB05153Cabozantinib2Terminated1
DB08875Cabozantinib2Terminated1
DB00958Carboplatin2Active Not Recruiting3
DB00958Carboplatin2Recruiting2
DB00958Carboplatin2Terminated1
DB04849Cediranib2Active Not Recruiting1
DB14707Cemiplimab2Recruiting1
DB15421Cetrelimab2Recruiting1
DB14681Cortisone2Active Not Recruiting1
DB14681Cortisone2Completed1
DB14681Cortisone2Recruiting4
DB12941Darolutamide2Active Not Recruiting1
DB12941Darolutamide2Not Yet Recruiting1
DB12941Darolutamide2Recruiting3
DB01254Dasatinib2Not Yet Recruiting1
DB06699Degarelix2Recruiting1
DB06699Degarelix2Withdrawn1
DB01248Docetaxel2Active Not Recruiting2
DB01248Docetaxel2Completed7
DB01248Docetaxel2Recruiting5
DB01248Docetaxel2Terminated2
DB14554Dotatate2Active Not Recruiting1
DB13925Dotatate gallium Ga-682Active Not Recruiting1
DB08899Enzalutamide2Completed4
DB08899Enzalutamide2Recruiting5
DB08899Enzalutamide2Terminated1
DB12147Erdafitinib2Recruiting1
DB01196Estramustine2Completed1
DB14674Estramustine phosphate2Completed1
DB13146Fluciclovine (18F)2Recruiting1
DB09502Fludeoxyglucose (18F)2Recruiting2
DB09398Fluoride ion F-182Recruiting1
DB16019Gallium Ga-68 gozetotide2Completed1
DB16019Gallium Ga-68 gozetotide2Not Yet Recruiting1
DB16019Gallium Ga-68 gozetotide2Recruiting2
DB16303Gallium-68 PSMA2Completed1
DB16303Gallium-68 PSMA2Not Yet Recruiting1
DB16303Gallium-68 PSMA2Recruiting3
DB12827Indoximod2Completed1
DB11997Interleukin-72Completed1
DB06186Ipilimumab2Active Not Recruiting1
DB06186Ipilimumab2Recruiting1
DB12167LY-30234142Completed1
DB00480Lenalidomide2Completed1
DB09078Lenvatinib2Recruiting1
DB00007Leuprolide2Recruiting2
DB00007Leuprolide2Withdrawn1
DB00281Lidocaine2Withdrawn1
DB00331Metformin2Completed1
DB00331Metformin2Not Yet Recruiting2
DB00959Methylprednisolone2Active Not Recruiting1
DB00959Methylprednisolone2Completed3
DB00959Methylprednisolone2Recruiting3
DB01204Mitoxantrone2Terminated1
DB11828Neratinib2Recruiting1
DB06803Niclosamide2Recruiting1
DB11793Niraparib2Recruiting1
DB09035Nivolumab2Active Not Recruiting1
DB09035Nivolumab2Recruiting2
DB09074Olaparib2Active Not Recruiting2
DB09074Olaparib2Recruiting1
DB03010Patupilone2Completed1
DB09037Pembrolizumab2Recruiting3
DB01174Phenobarbital2Recruiting1
DB14805Piflufolastat F 182Recruiting2
DB00635Prednisone2Active Not Recruiting1
DB00635Prednisone2Completed6
DB00635Prednisone2Recruiting8
DB00635Prednisone2Terminated2
DB12813Radium Ra-2232Active Not Recruiting1
DB12332Rucaparib2Recruiting1
DB06688Sipuleucel-T2Completed4
DB00398Sorafenib2Terminated1
DB01268Sunitinib2Completed1
DB11760Talazoparib2Not Yet Recruiting1
DB11760Talazoparib2Recruiting2
DB05861Tasquinimod2Completed1
DB15232Telaglenastat2Not Yet Recruiting1
DB00624Testosterone2Active Not Recruiting1
DB00624Testosterone2Recruiting1
DB08911Trametinib2Active Not Recruiting1
DB00135Tyrosine2Recruiting1
DB03904Urea2Completed1
DB03904Urea2Not Yet Recruiting1
DB03904Urea2Recruiting1
DB05812Abiraterone2 / 3Active Not Recruiting1
DB05812Abiraterone2 / 3Recruiting1
DB11901Apalutamide2 / 3Recruiting1
DB01128Bicalutamide2 / 3Recruiting1
DB06772Cabazitaxel2 / 3Active Not Recruiting1
DB06699Degarelix2 / 3Recruiting1
DB01248Docetaxel2 / 3Recruiting1
DB08899Enzalutamide2 / 3Active Not Recruiting1
DB08899Enzalutamide2 / 3Recruiting1
DB00499Flutamide2 / 3Recruiting1
DB00014Goserelin2 / 3Recruiting1
DB06788Histrelin2 / 3Recruiting1
DB00007Leuprolide2 / 3Recruiting1
DB00959Methylprednisolone2 / 3Recruiting1
DB00665Nilutamide2 / 3Recruiting1
DB00635Prednisone2 / 3Recruiting1
DB06825Triptorelin2 / 3Recruiting1
DB05812Abiraterone3Active Not Recruiting2
DB05812Abiraterone3Recruiting2
DB11595Atezolizumab3Recruiting1
DB01076Atorvastatin3Recruiting1
DB00112Bevacizumab3Active Not Recruiting1
DB06772Cabazitaxel3Completed1
DB06772Cabazitaxel3Recruiting1
DB08875Cabozantinib3Recruiting1
DB14547Chloride ion3Active Not Recruiting1
DB00122Choline3Completed1
DB09277Choline C 113Completed1
DB00515Cisplatin3Active Not Recruiting1
DB12941Darolutamide3Not Yet Recruiting1
DB06643Denosumab3Active Not Recruiting1
DB01248Docetaxel3Active Not Recruiting1
DB08899Enzalutamide3Recruiting2
DB00099Filgrastim3Recruiting1
DB13146Fluciclovine (18F)3Recruiting1
DB00441Gemcitabine3Active Not Recruiting1
DB11743Ipatasertib3Active Not Recruiting1
DB13144Lenograstim3Recruiting1
DB14805Piflufolastat F 183Completed1
DB12257Platinum3Active Not Recruiting1
DB00860Prednisolone3Active Not Recruiting1
DB00635Prednisone3Active Not Recruiting1
DB00635Prednisone3Recruiting3
DB00884Risedronic acid3Terminated1
DB05812Abiraterone4Completed1
DB05812Abiraterone4Recruiting1
DB01128Bicalutamide4Withdrawn1
DB06772Cabazitaxel4Completed2
DB01234Dexamethasone4Recruiting1
DB08899Enzalutamide4Completed1
DB08899Enzalutamide4Recruiting1
DB00644Gonadorelin4Recruiting1
DB00014Goserelin4Withdrawn1
DB00007Leuprolide4Terminated1
DB00860Prednisolone4Completed1
DB00635Prednisone4Completed2
DB00635Prednisone4Recruiting1
DB12813Radium Ra-2234Recruiting1
DB01098Rosuvastatin4Completed1
DB00482CelecoxibNot AvailableCompleted1
DB01234DexamethasoneNot AvailableTerminated1
DB01248DocetaxelNot AvailableCompleted1
DB05094EnzalutamideNot AvailableTerminated1
DB08899EnzalutamideNot AvailableTerminated1
DB16019Gallium Ga-68 gozetotideNot AvailableAvailable2
DB16303Gallium-68 PSMANot AvailableAvailable1
DB00644GonadorelinNot AvailableRecruiting1
DB00014GoserelinNot AvailableRecruiting1
DB08913Radium Ra 223 dichlorideNot AvailableCompleted1
DB08913Radium Ra 223 dichlorideNot AvailableRecruiting1
DB00399Zoledronic acidNot AvailableCompleted1