Lennox-Gastaut Syndrome

Also known as: Lennox Gastaut Syndrome (LGS) / Lennox-Gastaut Syndrome (LGS) / Lennox Gastaut Syndrome / Lennox-Gastaut syndrome (disorder) / Cutis verticis gyrata / Cutis verticis gyrata (disorder)

DrugDrug NameDrug Description
DB09061CannabidiolAn active cannabinoid used as an adjunctive treatment for the management of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome and symptomatic relief of moderate to severe neuropathic pain or other painful conditions, like cancer.
DB00349ClobazamA benzodiazepine used as adjunct treatment in seizures associated with Lennox-Gastaut syndrome.
DB01068ClonazepamA long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures.
DB00574FenfluramineFenfluramine is a phenethylamine that is structurally similar to serotonin. Due to its ability to increase extracellular serotonin levels, modulate serotonergic and other neurologic receptors, and control neurotransmission, it is effective in treating pharmacoresistant seizures.
DB00555LamotrigineA phenyltriazine antiepileptic used to treat some types of epilepsy and bipolar I disorder.
DB06201RufinamideAn antiepileptic drug used as adjunctive therapy to treat seizures associated with Lennox-Gastaut Syndrome (LGS).
DB00273TopiramateAn anticonvulsant drug used in the control of epilepsy and in the prophylaxis and treatment of migraines.
DrugDrug NameTargetType
DB09061CannabidiolCytochrome P450 2C9enzyme
DB09061CannabidiolCytochrome P450 2C19enzyme
DB09061CannabidiolCytochrome P450 2D6enzyme
DB09061CannabidiolCytochrome P450 3A4enzyme
DB09061CannabidiolCannabinoid receptor 1target
DB09061CannabidiolCannabinoid receptor 2target
DB09061CannabidiolG-protein coupled receptor 12target
DB09061CannabidiolGlycine receptor subunit alpha-1target
DB09061CannabidiolGlycine receptor (alpha-1/beta)target
DB09061CannabidiolGlycine receptor subunit alpha-3target
DB09061CannabidiolN-arachidonyl glycine receptortarget
DB09061CannabidiolG-protein coupled receptor 55target
DB09061Cannabidiol5-hydroxytryptamine receptor 1Atarget
DB09061Cannabidiol5-hydroxytryptamine receptor 2Atarget
DB09061CannabidiolNeuronal acetylcholine receptor subunit alpha-7target
DB09061CannabidiolDelta-type opioid receptortarget
DB09061CannabidiolMu-type opioid receptortarget
DB09061CannabidiolPeroxisome proliferator-activated receptor gammatarget
DB09061CannabidiolCytochrome P450 3A5enzyme
DB09061CannabidiolSerotonin N-acetyltransferaseenzyme
DB09061CannabidiolCytochrome P450 1A1enzyme
DB09061CannabidiolFatty-acid amide hydrolase 1enzyme
DB09061CannabidiolArachidonate 5-lipoxygenaseenzyme
DB09061CannabidiolArachidonate 15-lipoxygenaseenzyme
DB09061CannabidiolQuinone oxidoreductaseenzyme
DB09061CannabidiolMultidrug resistance-associated protein 1transporter
DB09061CannabidiolATP-binding cassette sub-family G member 2transporter
DB09061CannabidiolEquilibrative nucleoside transporter 1transporter
DB09061CannabidiolTransient receptor potential cation channel subfamily V member 1target
DB09061CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1Gtarget
DB09061CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1Htarget
DB09061CannabidiolVoltage-dependent T-type calcium channel subunit alpha-1Itarget
DB09061CannabidiolTransient receptor potential cation channel subfamily A member 1target
DB09061CannabidiolTransient receptor potential cation channel subfamily M member 8target
DB09061CannabidiolTransient receptor potential cation channel subfamily V member 2target
DB09061CannabidiolTransient receptor potential cation channel subfamily V member 3target
DB09061CannabidiolTransient receptor potential cation channel subfamily V member 4target
DB09061CannabidiolVoltage-dependent anion-selective channel protein 1target
DB09061Cannabidiol5-hydroxytryptamine receptor 3Atarget
DB09061CannabidiolAdenosine receptor A1target
DB09061CannabidiolProstaglandin G/H synthase 1target
DB09061CannabidiolProstaglandin G/H synthase 2target
DB09061CannabidiolAcetyl-CoA acetyltransferase, mitochondrialtarget
DB09061CannabidiolSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB09061Cannabidiol3-hydroxy-3-methylglutaryl-coenzyme A reductasetarget
DB09061CannabidiolGlutathione reductase, mitochondrialtarget
DB09061CannabidiolGlutathione peroxidase 1target
DB09061CannabidiolIndoleamine 2,3-dioxygenase 1target
DB09061CannabidiolCytochrome P450 1B1target
DB09061CannabidiolNAD(P)H dehydrogenase [quinone] 1target
DB09061CannabidiolCatalasetarget
DB09061CannabidiolCytochrome P450 3A5target
DB09061CannabidiolCytochrome P450 2D6target
DB09061CannabidiolSuperoxide dismutase [Cu-Zn]target
DB09061CannabidiolCytochrome P450 1A2target
DB09061CannabidiolCytochrome P450 3A7target
DB09061CannabidiolSerotonin N-acetyltransferasetarget
DB09061CannabidiolN-acylethanolamine-hydrolyzing acid amidasetarget
DB09061CannabidiolCytochrome P450 1A2enzyme
DB09061CannabidiolCytochrome P450 1B1enzyme
DB09061CannabidiolCytochrome P450 2A6enzyme
DB09061CannabidiolCytochrome P450 2B6enzyme
DB09061CannabidiolCytochrome P450 2C8enzyme
DB09061CannabidiolCytochrome P450 2E1enzyme
DB09061CannabidiolCytochrome P450 3A7enzyme
DB09061CannabidiolUDP-glucuronosyltransferase 1-7enzyme
DB09061CannabidiolUDP-glucuronosyltransferase 1-9enzyme
DB09061CannabidiolUDP-glucuronosyltransferase 2B7enzyme
DB09061CannabidiolUDP-glucuronosyltransferase 2B17enzyme
DB09061CannabidiolP-glycoprotein 1transporter
DB09061CannabidiolCytochrome P450 2J2enzyme
DB09061CannabidiolLiver carboxylesterase 1enzyme
DB00349ClobazamCytochrome P450 2C19enzyme
DB00349ClobazamCytochrome P450 3A4enzyme
DB00349ClobazamCytochrome P450 2B6enzyme
DB00349ClobazamCytochrome P450 2C18enzyme
DB00349ClobazamP-glycoprotein 1transporter
DB00349ClobazamGABA(A) Receptortarget
DB00349ClobazamCytochrome P450 2D6enzyme
DB00349ClobazamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00349ClobazamSerum albumincarrier
DB00349ClobazamAlpha-1-acid glycoprotein 1carrier
DB00349ClobazamCytochrome P450 2C9enzyme
DB00349ClobazamUDP-glucuronosyltransferase 1-4enzyme
DB00349ClobazamUDP-glucuronosyltransferase 1-6enzyme
DB00349ClobazamUDP-glucuronosyltransferase 2B4enzyme
DB00349ClobazamUDP-glucuronosyltransferase 1-1enzyme
DB00349ClobazamCytochrome P450 1A2enzyme
DB00349ClobazamCytochrome P450 2C8enzyme
DB00349ClobazamCytochrome P450 3A5enzyme
DB00349ClobazamCytochrome P450 3A7enzyme
DB01068ClonazepamCytochrome P450 3A4enzyme
DB01068ClonazepamSerum albumincarrier
DB01068ClonazepamCytochrome P450 2E1enzyme
DB01068ClonazepamArylamine N-acetyltransferase 2enzyme
DB01068ClonazepamGABA(A) Receptortarget
DB01068ClonazepamNuclear receptor subfamily 1 group I member 2target
DB01068ClonazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00574Fenfluramine5-hydroxytryptamine receptor 2Ctarget
DB00574Fenfluramine5-hydroxytryptamine receptor 2Btarget
DB00574FenfluramineCytochrome P450 2D6enzyme
DB00574FenfluramineSodium-dependent serotonin transportertarget
DB00574Fenfluramine5-hydroxytryptamine receptor 2Atarget
DB00574Fenfluramine5-hydroxytryptamine receptor 1Dtarget
DB00574FenfluramineSigma non-opioid intracellular receptor 1target
DB00574Fenfluramine5-hydroxytryptamine receptor 1Atarget
DB00574FenfluramineCytochrome P450 1A2enzyme
DB00574FenfluramineCytochrome P450 2B6enzyme
DB00574FenfluramineCytochrome P450 2C9enzyme
DB00574FenfluramineCytochrome P450 2C19enzyme
DB00574FenfluramineCytochrome P450 3A4enzyme
DB00574FenfluramineCytochrome P450 3A5enzyme
DB00555LamotrigineVoltage-gated sodium channel alpha subunittarget
DB00555LamotrigineUDP-glucuronosyltransferases (UGTs)enzyme
DB00555LamotrigineP-glycoprotein 1transporter
DB00555LamotrigineDihydrofolate reductaseenzyme
DB00555Lamotrigine5-hydroxytryptamine receptor 3Atarget
DB00555LamotrigineVoltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)target
DB00555LamotrigineAdenosine receptor A1target
DB00555LamotrigineAdenosine receptor A2atarget
DB00555LamotrigineAlpha-1A adrenergic receptortarget
DB00555LamotrigineAlpha-2A adrenergic receptortarget
DB00555LamotrigineBeta-1 adrenergic receptortarget
DB00555LamotrigineD(1) dopamine receptortarget
DB00555LamotrigineDopamine D2 receptortarget
DB00555LamotrigineGABA(A) Receptortarget
DB00555LamotrigineGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00555LamotrigineHistamine H1 receptortarget
DB00555LamotrigineKappa-type opioid receptortarget
DB00555LamotrigineAcetylcholine receptor subunit alphatarget
DB00555Lamotrigine5-hydroxytryptamine receptor 2Atarget
DB00555LamotrigineSolute carrier family 22 member 2transporter
DB00555LamotrigineSerum albumincarrier
DB00555LamotrigineSolute carrier family 22 member 1transporter
DB00555LamotrigineGlutamate receptor 1target
DB06201RufinamideMetabotropic glutamate receptor 5target
DB06201RufinamideLiver carboxylesterase 1enzyme
DB06201RufinamideSodium channel protein type 9 subunit alphatarget
DB06201RufinamideSerum albumincarrier
DB06201RufinamideCytochrome P450 2E1enzyme
DB06201RufinamideCytochrome P450 3A4enzyme
DB00273TopiramateGamma-aminobutyric acid receptor subunit alpha-1target
DB00273TopiramateVoltage-gated sodium channel alpha subunittarget
DB00273TopiramateCarbonic anhydrase 2target
DB00273TopiramateCarbonic anhydrase 4target
DB00273TopiramateKainate receptorstarget
DB00273TopiramateCytochrome P450 2C19enzyme
DB00273TopiramateCytochrome P450 3A4enzyme
DB00273TopiramateCarbonic anhydrase 1target
DB00273TopiramateCarbonic anhydrase 3target
DB00273TopiramateVoltage gated L-type calcium channeltarget
DB00273TopiramateVoltage-dependent R-type calcium channeltarget
DB00273TopiramateSerum albumincarrier
DB00273TopiramateP-glycoprotein 1transporter
DB00273Topiramate5'-AMP-activated protein kinasetransporter
DrugDrug NamePhaseStatusCount
DB09061Cannabidiol1Completed1
DB12338Carisbamate1Completed2
DB00574Fenfluramine1Completed1
DB18885Bexicaserin1 / 2Completed1
DB09061Cannabidiol1 / 2Terminated1
DB18885Bexicaserin2Active Not Recruiting1
DB15932Clemizole2Not Yet Recruiting1
DB00574Fenfluramine2Active Not Recruiting1
DB16987Soticlestat2Active Not Recruiting1
DB16987Soticlestat2Completed1
DB09061Cannabidiol3Completed3
DB09061Cannabidiol3Unknown Status1
DB09061Cannabidiol3Withdrawn1
DB12338Carisbamate3Recruiting1
DB00349Clobazam3Completed1
DB00574Fenfluramine3Active Not Recruiting2
DB00334Olanzapine3Completed1
DB08883Perampanel3Terminated1
DB06201Rufinamide3Completed3
DB16987Soticlestat3Completed1
DB16987Soticlestat3Recruiting2
DB00273Topiramate3Completed1
DB09061Cannabidiol4Active Not Recruiting1
DB09061Cannabidiol4Withdrawn1
DB16956L-Acetylleucine4Withdrawn1
DB01065Melatonin4Withdrawn1
DB18885BexicaserinNot AvailableAvailable1
DB09061CannabidiolNot AvailableNot Yet Recruiting1
DB08883PerampanelNot AvailableAvailable1
DB06201RufinamideNot AvailableAvailable1
DB06201RufinamideNot AvailableCompleted1