Amyotrophic Lateral Sclerosis (ALS)

Also known as: Lateral Amyotrophic Sclerosis / Amyotrophic lateral sclerosis(ALS) / ALS / Progressive Muscular Atrophy / Amyotrophic Lateral Sclerosis / ALS (Amyotrophic Lateral Sclerosis) / Amyotrophic lateral sclerosis (disorder) / Progressive muscular atrophy (disorder)

Drug	Drug Name	Drug Description
DB12243	Edaravone	A free radical scavenger used to delay the progression of ALS.
DB00740	Riluzole	A glutamate antagonist used to treat amyotrophic lateral sclerosis.

Drug	Drug Name	Target	Type
DB12243	Edaravone	Solute carrier family 22 member 6	transporter
DB12243	Edaravone	Solute carrier family 22 member 8	transporter
DB00740	Riluzole	Sodium channel protein type 5 subunit alpha	target
DB00740	Riluzole	Cytochrome P450 1A2	enzyme
DB00740	Riluzole	Cystine/glutamate transporter	target
DB00740	Riluzole	ATP-binding cassette sub-family G member 2	transporter
DB00740	Riluzole	Cytochrome P450 1A1	enzyme

Drug	Drug Name	Phase	Status	Count
DB06774	Capsaicin	0	Completed	2
DB08883	Perampanel	0	Completed	1
DB14759	Red pepper	0	Completed	2
DB00740	Riluzole	0	Completed	1
DB08839	Serotonin	0	Completed	1
DB06616	Bosutinib	1	Recruiting	1
DB00201	Caffeine	1	Completed	1
DB00190	Carbidopa	1	Enrolling by Invitation	1
DB00482	Celecoxib	1	Active Not Recruiting	1
DB00501	Cimetidine	1	Completed	1
DB00537	Ciprofloxacin	1	Active Not Recruiting	1
DB09130	Copper	1	Completed	1
DB01264	Darunavir	1	Recruiting	1
DB15130	Dexpramipexole	1	Completed	4
DB08930	Dolutegravir	1	Recruiting	1
DB09148	Florbetaben (18F)	1	Recruiting	1
DB14865	Human interleukin-2	1	Unknown Status	1
DB04335	Inosine	1	Completed	1
DB01235	Levodopa	1	Enrolling by Invitation	1
DB00683	Midazolam	1	Completed	1
DB00218	Moxifloxacin	1	Completed	1
DB12891	Ozanezumab	1	Completed	1
DB01129	Rabeprazole	1	Completed	2
DB00503	Ritonavir	1	Recruiting	1
DB12639	Telbermin	1	Terminated	1
DB09299	Tenofovir alafenamide	1	Recruiting	1
DB11817	Baricitinib	1 / 2	Not Yet Recruiting	1
DB09130	Copper	1 / 2	Active Not Recruiting	1
DB09130	Copper	1 / 2	Completed	1
DB00514	Dextromethorphan	1 / 2	Completed	1
DB00467	Enoxacin	1 / 2	Recruiting	1
DB00016	Erythropoietin	1 / 2	Recruiting	1
DB05066	Ibudilast	1 / 2	Completed	1
DB05266	Ibudilast	1 / 2	Completed	1
DB06218	Lacosamide	1 / 2	Completed	1
DB06819	Phenylbutyric acid	1 / 2	Completed	1
DB01132	Pioglitazone	1 / 2	Completed	1
DB00413	Pramipexole	1 / 2	Completed	2
DB00908	Quinidine	1 / 2	Completed	1
DB00740	Riluzole	1 / 2	Recruiting	1
DB00133	Serine	1 / 2	Unknown Status	1
DB00675	Tamoxifen	1 / 2	Completed	1
DB08911	Trametinib	1 / 2	Recruiting	1
DB00755	Tretinoin	1 / 2	Completed	1
DB11677	Triheptanoin	1 / 2	Completed	1
DB01593	Zinc	1 / 2	Completed	1
DB01048	Abacavir	2	Completed	1
DB00062	Albumin human	2	Completed	2
DB00041	Aldesleukin	2	Active Not Recruiting	1
DB00041	Aldesleukin	2	Completed	1
DB00026	Anakinra	2	Unknown Status	1
DB05025	Arimoclomol	2	Completed	1
DB05025	Arimoclomol	2	Withdrawn	1
DB11887	Arundic acid	2	Completed	2
DB00572	Atropine	2	Not Yet Recruiting	1
DB00074	Basiliximab	2	Completed	1
DB00121	Biotin	2	Completed	2
DB00083	Botulinum toxin type A	2	Completed	1
DB00083	Botulinum toxin type A	2	Withdrawn	1
DB00482	Celecoxib	2	Completed	2
DB00537	Ciprofloxacin	2	Completed	1
DB01407	Clenbuterol	2	Completed	1
DB01394	Colchicine	2	Active Not Recruiting	1
DB09130	Copper	2	Recruiting	1
DB01285	Corticotropin	2	Completed	1
DB00148	Creatine	2	Completed	3
DB11846	Creatinine	2	Completed	1
DB01003	Cromoglicic acid	2	Terminated	1
DB08826	Deferiprone	2	Completed	1
DB00633	Dexmedetomidine	2	Not Yet Recruiting	1
DB15130	Dexpramipexole	2	Completed	2
DB00514	Dextromethorphan	2	Completed	1
DB08930	Dolutegravir	2	Completed	1
DB16041	EPI-589	2	Completed	1
DB12243	Edaravone	2	Not Yet Recruiting	1
DB00016	Erythropoietin	2	Completed	1
DB04953	Ezogabine	2	Completed	1
DB08162	Fasudil	2	Recruiting	1
DB12469	Fasudil	2	Unknown Status	1
DB00099	Filgrastim	2	Completed	2
DB08868	Fingolimod	2	Completed	1
DB05259	Glatiramer	2	Completed	1
DB14154	Gold	2	Not Yet Recruiting	1
DB15726	Human Umbilical Cord Mesenchymal Stem Cells	2	Recruiting	1
DB14865	Human interleukin-2	2	Active Not Recruiting	1
DB05266	Ibudilast	2	Completed	1
DB04335	Inosine	2	Completed	1
DB00709	Lamivudine	2	Completed	1
DB00007	Leuprolide	2	Completed	1
DB01202	Levetiracetam	2	Completed	1
DB00922	Levosimendan	2	Completed	1
DB14104	Linoleic acid	2	Recruiting	1
DB14509	Lithium carbonate	2	Completed	2
DB16223	Lunasine	2	Completed	1
DB14009	Medical Cannabis	2	Recruiting	1
DB01043	Memantine	2	Completed	3
DB00959	Methylprednisolone	2	Completed	1
DB01017	Minocycline	2	Completed	1
DB00688	Mycophenolate mofetil	2	Completed	1
DB00336	Nitrofural	2	Recruiting	1
DB12891	Ozanezumab	2	Completed	1
DB16694	Pegcetacoplan	2	Recruiting	1
DB08883	Perampanel	2	Completed	1
DB08883	Perampanel	2	Terminated	1
DB06819	Phenylbutyric acid	2	Completed	1
DB01100	Pimozide	2	Active Not Recruiting	1
DB01100	Pimozide	2	Recruiting	1
DB01132	Pioglitazone	2	Terminated	1
DB00635	Prednisone	2	Completed	1
DB00908	Quinidine	2	Completed	1
DB00243	Ranolazine	2	Recruiting	1
DB01367	Rasagiline	2	Completed	3
DB15256	Reldesemtiv	2	Completed	1
DB00740	Riluzole	2	Active Not Recruiting	2
DB00740	Riluzole	2	Completed	4
DB00740	Riluzole	2	Terminated	1
DB00740	Riluzole	2	Withdrawn	1
DB09446	Safflower oil	2	Recruiting	1
DB00747	Scopolamine	2	Not Yet Recruiting	1
DB00133	Serine	2	Recruiting	1
DB00877	Sirolimus	2	Active Not Recruiting	1
DB00052	Somatotropin	2	Completed	1
DB00864	Tacrolimus	2	Completed	1
DB04982	Talampanel	2	Completed	1
DB04982	Talampanel	2	Terminated	1
DB00675	Tamoxifen	2	Completed	2
DB08834	Tauroursodeoxycholic acid	2	Completed	1
DB00624	Testosterone	2	Completed	1
DB01041	Thalidomide	2	Completed	1
DB01041	Thalidomide	2	Terminated	1
DB12129	Tideglusib	2	Not Yet Recruiting	1
DB12209	Tirasemtiv	2	Completed	4
DB06273	Tocilizumab	2	Completed	1
DB09069	Trimetazidine	2	Recruiting	1
DB09270	Ubidecarenone	2	Completed	1
DB01586	Ursodeoxycholic acid	2	Completed	1
DB05025	Arimoclomol	2 / 3	Completed	1
DB00042	Botulinum toxin type B	2 / 3	Completed	1
DB09061	Cannabidiol	2 / 3	Completed	1
DB01285	Corticotropin	2 / 3	Terminated	1
DB08826	Deferiprone	2 / 3	Recruiting	1
DB00470	Dronabinol	2 / 3	Completed	1
DB00099	Filgrastim	2 / 3	Completed	1
DB05266	Ibudilast	2 / 3	Recruiting	1
DB14509	Lithium carbonate	2 / 3	Terminated	1
DB11526	Masitinib	2 / 3	Completed	1
DB03614	Mecobalamin	2 / 3	Completed	2
DB14009	Medical Cannabis	2 / 3	Completed	1
DB01043	Memantine	2 / 3	Completed	1
DB00334	Olanzapine	2 / 3	Unknown Status	1
DB11947	Pridopidine	2 / 3	Enrolling by Invitation	1
DB11947	Pridopidine	2 / 3	Recruiting	1
DB00740	Riluzole	2 / 3	Completed	2
DB00740	Riluzole	2 / 3	Recruiting	1
DB00740	Riluzole	2 / 3	Terminated	1
DB05185	TRO19622	2 / 3	Completed	1
DB12440	Verdiperstat	2 / 3	Active Not Recruiting	1
DB12440	Verdiperstat	2 / 3	Recruiting	1
DB15636	Zilucoplan	2 / 3	Active Not Recruiting	1
DB15636	Zilucoplan	2 / 3	Recruiting	1
DB01048	Abacavir	3	Not Yet Recruiting	1
DB05025	Arimoclomol	3	Completed	1
DB05025	Arimoclomol	3	Terminated	1
DB01212	Ceftriaxone	3	Completed	1
DB15130	Dexpramipexole	3	Completed	1
DB15130	Dexpramipexole	3	Terminated	1
DB08930	Dolutegravir	3	Not Yet Recruiting	1
DB12243	Edaravone	3	Completed	5
DB12243	Edaravone	3	Not Yet Recruiting	1
DB12243	Edaravone	3	Recruiting	2
DB01175	Escitalopram	3	Completed	1
DB08824	Ioflupane I-123	3	Completed	1
DB00709	Lamivudine	3	Not Yet Recruiting	1
DB00922	Levosimendan	3	Completed	2
DB11526	Masitinib	3	Recruiting	1
DB03614	Mecobalamin	3	Unknown Status	1
DB01017	Minocycline	3	Completed	1
DB11580	Ravulizumab	3	Terminated	1
DB15256	Reldesemtiv	3	Recruiting	1
DB00740	Riluzole	3	Completed	1
DB00740	Riluzole	3	Recruiting	2
DB05185	TRO19622	3	Completed	1
DB08834	Tauroursodeoxycholic acid	3	Recruiting	1
DB12209	Tirasemtiv	3	Completed	2
DB14782	Tofersen	3	Completed	1
DB01586	Ursodeoxycholic acid	3	Recruiting	1
DB00313	Valproic acid	3	Completed	1
DB00740	Riluzole	4	Completed	1
DB15729	Adipose-Derived Mesenchymal Stem Cells: Autologous or Allogeneic Origins	Not Available	No Longer Available	1
DB06774	Capsaicin	Not Available	Recruiting	1
DB08826	Deferiprone	Not Available	Completed	1
DB00470	Dronabinol	Not Available	Completed	1
DB12243	Edaravone	Not Available	Recruiting	1
DB00099	Filgrastim	Not Available	Completed	1
DB14914	Flortaucipir F-18	Not Available	Completed	1
DB14154	Gold	Not Available	Available	1
DB00166	Lipoic acid	Not Available	Recruiting	1
DB14043	Palmidrol	Not Available	Completed	1
DB08883	Perampanel	Not Available	Recruiting	1
DB00413	Pramipexole	Not Available	Temporarily Not Available	1
DB00740	Riluzole	Not Available	Completed	1
DB00740	Riluzole	Not Available	No Longer Available	1