Vasomotor Symptoms Associated With Menopause

Also known as: Vasomotor menopausal symptoms / Vasomotor Symptoms caused by Menopause / Menopausal Vasomotor Symptoms / Vasomotor Symptoms / Vasomotor Symptoms (VMS) / Efaffb79-f1b2-421d-a6aa-65ec8e42c33e caused by Menopause / Menopausal symptoms / Menopausal symptoms (finding) / Menopausal symptom (finding) / Menopausal symptoms NOS (disorder)

DrugDrug NameDrug Description
DB00783EstradiolAn estrogenic steroid used to treat vasomotor symptoms of vulvar and vaginal atrophy in menopause, hypoestrogenism, prevention of postmenopausal osteoporosis, treatment of breast cancer, and advanced androgen-dependent carcinoma of the prostate.
DB00603Medroxyprogesterone acetateA progestin used as a contraceptive and in the treatment of secondary amenorrhea, abnormal uterine bleeding, pain from endometriosis, endometrial and renal carcinomas, paraphilia in males, and GnRH-dependent precocious puberty.
DB00715ParoxetineA selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder.
DB09070TiboloneFor the relief of post-menopausal symptoms and for the prevention of osteoporosis .
DB00285VenlafaxineA selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression, generalized or social anxiety disorder, and panic disorder.
DrugDrug NameTargetType
DB00783EstradiolEstrogen receptor alphatarget
DB00783EstradiolNuclear receptor subfamily 1 group I member 2target
DB00783EstradiolSex hormone-binding globulincarrier
DB00783EstradiolEstrogen receptor betatarget
DB00783EstradiolCytochrome P450 1A2enzyme
DB00783EstradiolUDP-glucuronosyltransferase 1-1enzyme
DB00783EstradiolSerum albumincarrier
DB00783EstradiolFatty acid-binding protein, intestinalcarrier
DB00783EstradiolCytochrome P450 3A4enzyme
DB00783EstradiolCytochrome P450 3A5enzyme
DB00783EstradiolCytochrome P450 3A7enzyme
DB00783EstradiolSolute carrier family 22 member 2transporter
DB00783EstradiolSolute carrier family 22 member 3transporter
DB00783EstradiolMultidrug resistance-associated protein 7transporter
DB00783EstradiolSolute carrier family 22 member 11transporter
DB00783EstradiolATP-binding cassette sub-family G member 2transporter
DB00783EstradiolSolute carrier organic anion transporter family member 1B1transporter
DB00783EstradiolP-glycoprotein 1transporter
DB00783EstradiolCytochrome P450 1A1enzyme
DB00783EstradiolCytochrome P450 1B1enzyme
DB00783EstradiolCytochrome P450 2C19enzyme
DB00783EstradiolCytochrome P450 2C8enzyme
DB00783EstradiolCytochrome P450 2C9enzyme
DB00783EstradiolSolute carrier family 22 member 8transporter
DB00783EstradiolSolute carrier organic anion transporter family member 1B3transporter
DB00783EstradiolSolute carrier organic anion transporter family member 1C1transporter
DB00783EstradiolNeuronal acetylcholine receptor subunit alpha-4target
DB00783EstradiolG-protein coupled estrogen receptor 1target
DB00783EstradiolATP synthase subunit atarget
DB00783EstradiolBeclin-1target
DB00783EstradiolUDP-glucuronosyltransferase 2B15enzyme
DB00783EstradiolCatechol O-methyltransferaseenzyme
DB00783EstradiolUDP-glucuronosyltransferases (UGTs)enzyme
DB00783EstradiolCytochrome P450 19A1enzyme
DB00603Medroxyprogesterone acetateProgesterone receptortarget
DB00603Medroxyprogesterone acetateEstrogen receptor alphatarget
DB00603Medroxyprogesterone acetateCytochrome P450 3A4enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 2C8enzyme
DB00603Medroxyprogesterone acetate3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 2C9enzyme
DB00603Medroxyprogesterone acetateCytochrome P450 3A1enzyme
DB00603Medroxyprogesterone acetateSerum albumincarrier
DB00603Medroxyprogesterone acetateP-glycoprotein 1target
DB00603Medroxyprogesterone acetateGABA(A) Receptortarget
DB00603Medroxyprogesterone acetateP-glycoprotein 1transporter
DB00715ParoxetineSodium-dependent serotonin transportertarget
DB00715ParoxetineSodium-dependent noradrenaline transportertarget
DB00715Paroxetine5-hydroxytryptamine receptor 2Atarget
DB00715ParoxetineCytochrome P450 2D6enzyme
DB00715ParoxetineCytochrome P450 2C9enzyme
DB00715ParoxetineP-glycoprotein 1transporter
DB00715ParoxetineCytochrome P450 2B6enzyme
DB00715ParoxetineCytochrome P450 1A2enzyme
DB00715ParoxetineCytochrome P450 3A4enzyme
DB00715ParoxetineAlpha-1 adrenergic receptorstarget
DB00715ParoxetineAlpha-2 adrenergic receptorstarget
DB00715ParoxetineBeta adrenergic receptortarget
DB00715ParoxetineDopamine D2 receptortarget
DB00715ParoxetineHistamine H1 receptortarget
DB00715ParoxetineSerotonin Receptorstarget
DB00715ParoxetineMuscarinic acetylcholine receptortarget
DB00715Paroxetine5-hydroxytryptamine receptor 2Btarget
DB00715ParoxetineD(1) dopamine receptortarget
DB00715ParoxetineCytochrome P450 2C19enzyme
DB09070TiboloneEstrogen receptor alphatarget
DB09070TiboloneSteryl-sulfataseenzyme
DB09070Tibolone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1enzyme
DB09070Tibolone3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2enzyme
DB09070TiboloneSulfotransferase 1A1enzyme
DB09070TiboloneSerum albumincarrier
DB00285VenlafaxineSodium-dependent serotonin transportertarget
DB00285VenlafaxineSodium-dependent noradrenaline transportertarget
DB00285VenlafaxineCytochrome P450 2D6enzyme
DB00285VenlafaxineCytochrome P450 3A4enzyme
DB00285VenlafaxineSodium-dependent dopamine transportertarget
DB00285VenlafaxineP-glycoprotein 1transporter
DB00285VenlafaxineATP-binding cassette sub-family G member 2transporter
DB00285VenlafaxineCytochrome P450 2C9enzyme
DB00285VenlafaxineCytochrome P450 2C19enzyme
DrugDrug NamePhaseStatusCount
DB00318Codeine1Completed1
DB06700Desvenlafaxine1Completed2
DB15287Elismetrep1Completed1
DB00783Estradiol1Active Not Recruiting1
DB00715Paroxetine1Completed1
DB00396Progesterone1Active Not Recruiting1
DB00297Bupivacaine2Recruiting1
DB00297Bupivacaine2Terminated1
DB06374Elacestrant2Terminated1
DB15287Elismetrep2Completed1
DB00783Estradiol2Completed1
DB00603Medroxyprogesterone acetate2Completed1
DB00481Raloxifene2Completed1
DB09153Sodium chloride2Recruiting1
DB16080Acolbifene3Completed1
DB06401Bazedoxifene3Completed1
DB06700Desvenlafaxine3Completed3
DB01395Drospirenone3Completed3
DB06678Esmirtazapine3Completed2
DB12235Estetrol3Active Not Recruiting1
DB12235Estetrol3Recruiting1
DB00783Estradiol3Completed5
DB15669Fezolinetant3Recruiting1
DB05052MF1013Unknown Status1
DB00717Norethisterone3Completed1
DB01708Prasterone3Completed1
DB00396Progesterone3Recruiting1
DB13975Black cohosh4Unknown Status1
DB00476Duloxetine4Completed1
DB00783Estradiol4Completed1
DB00783Estradiol4Unknown Status1
DB00603Medroxyprogesterone acetate4Unknown Status1
DB09070Tibolone4Completed1
DB06700DesvenlafaxineNot AvailableTerminated1
DB01175EscitalopramNot AvailableCompleted1
DB00996GabapentinNot AvailableWithdrawn1