Vulvovaginal Candidiasis

Also known as: Vulvovaginal Candidiases / Vulvovaginal candiasis / Vulvovaginal Candidiasis, Genital / Vulvovaginal Candidiasis (VVC) / Candidiasis, Vulvovaginal / Vulvo-vaginal Candidiasis / Candidal vulvovaginitis (disorder) / Candidal vulvovaginitis / Vulvovaginal candida / Candidiasis of vulva and vagina / Candidal vulvovaginitis NOS (disorder) / Candidal: [vulvovaginitis NOS] or [cervix]

DrugDrug NameDrug Description
DB00639ButoconazoleAn imidazole antifungal used to treat vulvovaginal candidiasis.
DB01188CiclopiroxA broad-spectrum topical antifungal agent used to treat mild to moderate onychomycosis of fingernails and toenails in immunocompetent patients.
DB12471IbrexafungerpA triterpene antifungal indicated in the treatment of vulvovaginal candidiasis in post-menarchal patients.
DB01167ItraconazoleAn antifungal agent used for the treatment of various fungal infections in immunocompromised and non-immunocompromised patients, such as pulmonary and extrapulmonary blastomycosis, histoplasmosis, and onychomycosis.
DB01026KetoconazoleA broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections.
DB00281LidocaineA local anesthetic used in a wide variety of superficial and invasive procedures.
DB00646NystatinA polyene ionophore antifungal used to treat cutaneous, mucocutaneous, and gastrointestinal mycotic infections, particularly those caused by Candida species.
DB01153SertaconazoleA topical antifungal agent used in the treatment of interdigital tinea pedis in immunocompetent patients.
DB00259SulfanilamideA sulfonamide anti-infective used to treat vulvovaginal candidiasis caused by Candida albicans.
DB00251TerconazoleAn antifungal drug used in the treatment of vulvovaginal candidiasis.
DB01007TioconazoleAn imidazole antifungal used to treat vulvovaginal candidiasis.
DrugDrug NameTargetType
DB00639ButoconazoleErgosteroltarget
DB01188CiclopiroxSodium/potassium-transporting ATPase subunit alpha-1target
DB12471IbrexafungerpCytochrome P450 3A4enzyme
DB12471IbrexafungerpUDP-glucuronosyltransferases (UGTs)enzyme
DB12471IbrexafungerpSulfotransferaseenzyme
DB12471IbrexafungerpCytochrome P450 2C8enzyme
DB12471IbrexafungerpP-glycoprotein 1transporter
DB12471IbrexafungerpSolute carrier organic anion transporter family member 1B3transporter
DB12471IbrexafungerpSerum albumincarrier
DB12471Ibrexafungerp1,3-beta-glucan synthase component GSC2target
DB12471IbrexafungerpGTP-binding protein RHO1target
DB01167ItraconazoleLanosterol 14-alpha demethylasetarget
DB01167ItraconazoleLanosterol 14-alpha demethylasetarget
DB01167ItraconazoleCytochrome P450 3A4enzyme
DB01167ItraconazoleCytochrome P450 3A5enzyme
DB01167ItraconazoleCytochrome P450 3A7enzyme
DB01167ItraconazoleCytochrome P450 2B6enzyme
DB01167ItraconazoleP-glycoprotein 1transporter
DB01167ItraconazoleCytochrome P450 1A1enzyme
DB01167ItraconazoleCytochrome P450 2E1enzyme
DB01167ItraconazoleSolute carrier organic anion transporter family member 2B1transporter
DB01026KetoconazoleCytochrome P450 3A4enzyme
DB01026KetoconazoleCytochrome P450 2C9enzyme
DB01026KetoconazoleCytochrome P450 2C19enzyme
DB01026KetoconazoleCytochrome P450 3A5enzyme
DB01026KetoconazoleCytochrome P450 1A2enzyme
DB01026KetoconazoleCytochrome P450 2C8enzyme
DB01026KetoconazoleCytochrome P450 1A1enzyme
DB01026KetoconazoleCytochrome P450 2D6enzyme
DB01026KetoconazoleBile salt export pumptransporter
DB01026KetoconazoleP-glycoprotein 1transporter
DB01026KetoconazoleCytochrome P450 11B1, mitochondrialenzyme
DB01026KetoconazoleCytochrome P450 1B1enzyme
DB01026KetoconazoleCytochrome P450 2A6enzyme
DB01026KetoconazoleCytochrome P450 2B6enzyme
DB01026KetoconazoleLanosterol 14-alpha demethylasetarget
DB01026KetoconazoleAndrogen receptortarget
DB01026KetoconazoleSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB01026KetoconazoleSteroid 21-hydroxylasetarget
DB01026KetoconazolePotassium voltage-gated channel subfamily H member 2target
DB01026KetoconazoleNuclear receptor subfamily 1 group I member 2target
DB01026KetoconazoleNuclear receptor subfamily 1 group I member 3target
DB01026KetoconazoleUDP-glucuronosyltransferase 1-1enzyme
DB01026KetoconazoleUDP-glucuronosyltransferase 2B7enzyme
DB01026KetoconazoleSolute carrier organic anion transporter family member 1B1transporter
DB01026KetoconazoleCytochrome P450 4F12enzyme
DB01026KetoconazoleLeukotriene-B(4) omega-hydroxylase 1enzyme
DB01026KetoconazoleSerum albumincarrier
DB01026KetoconazoleSex hormone-binding globulincarrier
DB01026KetoconazoleCytochrome P450 19A1enzyme
DB01026KetoconazoleUDP-glucuronosyltransferase 1-7enzyme
DB00281LidocaineSodium channel protein type 5 subunit alphatarget
DB00281LidocaineSodium channel protein type 10 subunit alphatarget
DB00281LidocaineEpidermal growth factor receptortarget
DB00281LidocaineSodium channel protein type 9 subunit alphatarget
DB00281LidocaineCytochrome P450 1A2enzyme
DB00281LidocaineCytochrome P450 2D6enzyme
DB00281LidocaineCytochrome P450 3A4enzyme
DB00281LidocaineCytochrome P450 3A5enzyme
DB00281LidocaineCytochrome P450 3A7enzyme
DB00281LidocaineSolute carrier family 22 member 5transporter
DB00281LidocaineP-glycoprotein 1transporter
DB00281LidocaineCytochrome P450 2A6enzyme
DB00281LidocaineCytochrome P450 2B6enzyme
DB00281LidocaineCytochrome P450 2C8enzyme
DB00281LidocaineCytochrome P450 2C9enzyme
DB00281LidocaineSodium channel protein type 4 subunit alphatarget
DB00281LidocaineAlpha-1-acid glycoprotein 1target
DB00281LidocaineAlpha-1-acid glycoprotein 2target
DB00646NystatinErgosteroltarget
DB00646NystatinSolute carrier organic anion transporter family member 1B1transporter
DB00646NystatinSolute carrier organic anion transporter family member 1B3transporter
DB01153SertaconazoleCytochrome P450 51target
DB00259SulfanilamideDihydropteroate synthasetarget
DB00251TerconazoleCytochrome P450 51target
DB01007TioconazoleLanosterol 14-alpha demethylasetarget
DB01007TioconazoleCytochrome P450 19A1enzyme
DB01007TioconazoleCytochrome P450 2C19enzyme
DB01007TioconazoleCytochrome P450 2E1enzyme
DB01007TioconazoleCytochrome P450 3A4enzyme
DB01007TioconazoleCytochrome P450 51target
DrugDrug NamePhaseStatusCount
DB15823Lactobacillus acidophilus0Completed1
DB16540Lactobacillus delbrueckii bulgaricus0Completed1
DB00257Clotrimazole1 / 2Recruiting1
DB11062Octisalate1 / 2Recruiting1
DB09535Octocrylene1 / 2Recruiting1
DB09321Zinc oxide1 / 2Recruiting1
DB00681Amphotericin B2Completed1
DB00681Amphotericin B2Withdrawn1
DB11594Domiphen2Not Yet Recruiting1
DB00196Fluconazole2Completed5
DB12471Ibrexafungerp2Completed1
DB01110Miconazole2Not Yet Recruiting1
DB14049Nitrate2Completed1
DB13055Oteseconazole2Completed1
DB16310Rezafungin2Completed1
DB00257Clotrimazole2 / 3Completed1
DB00681Amphotericin B3Completed1
DB11326Boric acid3Completed1
DB01190Clindamycin3Completed1
DB00257Clotrimazole3Completed1
DB00257Clotrimazole3Withdrawn1
DB00196Fluconazole3Completed2
DB01026Ketoconazole3Completed1
DB00759Tetracycline3Completed1
DB09321Zinc oxide3Completed1
DB00257Clotrimazole4Completed2
DB04209Dequalinium4Completed1
DB00196Fluconazole4Completed2
DB00196Fluconazole4Not Yet Recruiting1
DB01110Miconazole4Completed1
DB11062Octisalate4Not Yet Recruiting1
DB09535Octocrylene4Not Yet Recruiting1
DB00251Terconazole4Completed1
DB09321Zinc oxide4Not Yet Recruiting1
DB11326Boric acidNot AvailableNot Yet Recruiting1
DB00639ButoconazoleNot AvailableCompleted1
DB00257ClotrimazoleNot AvailableRecruiting1
DB01592IronNot AvailableCompleted1
DB01167ItraconazoleNot AvailableCompleted1
DB16543Lactobacillus gasseriNot AvailableCompleted1
DB00251TerconazoleNot AvailableCompleted1
DB00251TerconazoleNot AvailableNot Yet Recruiting1
DB09321Zinc oxideNot AvailableCompleted1