Panic Disorders

Also known as: Panic disorder / [X]Panic disorder [episodic paroxysmal anxiety] / Panic disorder NOS

DrugDrug NameDrug Description
DB00404AlprazolamA long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and generalized anxiety in addition to anxiety associated with depression.
DB00215CitalopramA selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression.
DB01242ClomipramineA tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder.
DB01068ClonazepamA long-acting benzodiazepine with intermediate onset commonly used to treat panic disorders, severe anxiety, and seizures.
DB01151DesipramineA tricyclic antidepressant used in the treatment of depression.
DB00458ImipramineA tricyclic antidepressant indicated for the treatment of depression and to reduce childhood enuresis.
DB00186LorazepamA long-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures.
DB00370MirtazapineA tetracyclic antidepressant used in the treatment of major depression and is used off-label as a drug for insomnia and to increase appetite.
DB00715ParoxetineA selective serotonin reuptake inhibitor used to treat major depressive disorder, panic disorder, OCD, social phobia, generalized anxiety disorder, the vasomotor symptoms of menopause, and premenstrual dysphoric disorder.
DB01104SertralineA selective serotonin reuptake inhibitor (SSRI) indicated to treat major depressive disorder, social anxiety disorder and many other psychiatric conditions.
DB00285VenlafaxineA selective serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of major depression.
DrugDrug NameTargetType
DB00404AlprazolamCytochrome P450 3A4enzyme
DB00404AlprazolamCytochrome P450 2C9enzyme
DB00404AlprazolamCytochrome P450 3A5enzyme
DB00404AlprazolamCytochrome P450 3A7enzyme
DB00404AlprazolamGABA(A) Receptortarget
DB00404AlprazolamSerum albumincarrier
DB00404Alprazolamalpha1-acid glycoproteincarrier
DB00404AlprazolamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00215CitalopramSodium-dependent serotonin transportertarget
DB00215CitalopramCytochrome P450 2C19enzyme
DB00215CitalopramCytochrome P450 2D6enzyme
DB00215CitalopramCytochrome P450 3A4enzyme
DB00215CitalopramP-glycoprotein 1transporter
DB00215CitalopramCytochrome P450 1A2enzyme
DB00215CitalopramHistamine H1 receptortarget
DB01242ClomipramineSodium-dependent serotonin transportertarget
DB01242ClomipramineSodium-dependent noradrenaline transportertarget
DB01242ClomipramineGlutathione S-transferase Ptarget
DB01242Clomipramine5-hydroxytryptamine receptor 2Atarget
DB01242ClomipramineCytochrome P450 1A2enzyme
DB01242ClomipramineCytochrome P450 2D6enzyme
DB01242ClomipramineCytochrome P450 2C19enzyme
DB01242ClomipramineP-glycoprotein 1transporter
DB01242ClomipramineCytochrome P450 3A4enzyme
DB01242Clomipramine5-hydroxytryptamine receptor 2Btarget
DB01242Clomipramine5-hydroxytryptamine receptor 2Ctarget
DB01242ClomipramineSerum albumincarrier
DB01068ClonazepamCytochrome P450 3A4enzyme
DB01068ClonazepamSerum albumincarrier
DB01068ClonazepamCytochrome P450 2E1enzyme
DB01068ClonazepamArylamine N-acetyltransferase 2enzyme
DB01068ClonazepamGABA(A) Receptortarget
DB01068ClonazepamNuclear receptor subfamily 1 group I member 2target
DB01068ClonazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB01151DesipramineMuscarinic acetylcholine receptor M1target
DB01151DesipramineSodium-dependent noradrenaline transportertarget
DB01151DesipramineBeta-2 adrenergic receptortarget
DB01151DesipramineMuscarinic acetylcholine receptor M2target
DB01151DesipramineSodium-dependent serotonin transportertarget
DB01151DesipramineHistamine H1 receptortarget
DB01151DesipramineBeta-1 adrenergic receptortarget
DB01151DesipramineCytochrome P450 2D6enzyme
DB01151DesipramineMuscarinic acetylcholine receptor M3target
DB01151DesipramineMuscarinic acetylcholine receptor M4target
DB01151DesipramineMuscarinic acetylcholine receptor M5target
DB01151DesipramineAlpha-1 adrenergic receptorstarget
DB01151Desipramine5-hydroxytryptamine receptor 2Atarget
DB01151DesipramineAlpha-1-acid glycoprotein 1carrier
DB01151DesipramineCytochrome P450 2B6enzyme
DB01151DesipramineCytochrome P450 3A4enzyme
DB01151DesipramineSolute carrier family 22 member 2transporter
DB01151DesipramineSolute carrier family 22 member 1transporter
DB01151DesipramineSolute carrier family 22 member 3transporter
DB01151DesipramineSolute carrier family 22 member 5transporter
DB01151DesipramineP-glycoprotein 1transporter
DB01151DesipramineSolute carrier family 22 member 4transporter
DB01151DesipramineCytochrome P450 1A2enzyme
DB01151DesipramineCytochrome P450 2E1enzyme
DB01151DesipramineSphingomyelin phosphodiesterasetarget
DB01151Desipramine5-hydroxytryptamine receptor 1Atarget
DB01151Desipramine5-hydroxytryptamine receptor 2Ctarget
DB01151DesipramineDopamine D2 receptortarget
DB01151DesipramineAlpha-2 adrenergic receptorstarget
DB00458ImipramineSodium-dependent noradrenaline transportertarget
DB00458ImipramineSodium-dependent serotonin transportertarget
DB00458ImipramineCytochrome P450 1A2enzyme
DB00458ImipramineCytochrome P450 2C19enzyme
DB00458ImipramineCytochrome P450 2D6enzyme
DB00458ImipramineHistamine H1 receptortarget
DB00458ImipramineAlpha-1A adrenergic receptortarget
DB00458Imipramine5-hydroxytryptamine receptor 2Atarget
DB00458ImipramineMuscarinic acetylcholine receptor M1target
DB00458ImipramineMuscarinic acetylcholine receptor M2target
DB00458ImipramineMuscarinic acetylcholine receptor M3target
DB00458ImipramineMuscarinic acetylcholine receptor M4target
DB00458ImipramineMuscarinic acetylcholine receptor M5target
DB00458ImipraminePotassium voltage-gated channel subfamily D member 2target
DB00458ImipraminePotassium voltage-gated channel subfamily D member 3target
DB00458ImipramineAlpha-1D adrenergic receptortarget
DB00458ImipramineAlpha-1-acid glycoprotein 1carrier
DB00458ImipramineSolute carrier family 22 member 2transporter
DB00458ImipramineSolute carrier family 22 member 3transporter
DB00458ImipramineP-glycoprotein 1transporter
DB00458ImipramineSolute carrier family 22 member 4transporter
DB00458ImipramineCytochrome P450 3A4enzyme
DB00458ImipramineCytochrome P450 2B6enzyme
DB00458ImipramineCytochrome P450 2C18enzyme
DB00458ImipramineCytochrome P450 2E1enzyme
DB00458ImipramineCytochrome P450 3A7enzyme
DB00458Imipramine5-hydroxytryptamine receptor 2Ctarget
DB00458ImipramineAlpha-1B adrenergic receptortarget
DB00458Imipramine5-hydroxytryptamine receptor 7target
DB00458ImipramineD(1) dopamine receptortarget
DB00458ImipramineDopamine D2 receptortarget
DB00458ImipraminePotassium voltage-gated channel subfamily H member 2target
DB00458ImipramineSodium-dependent dopamine transportertarget
DB00458Imipramine5-hydroxytryptamine receptor 1Atarget
DB00458Imipramine5-hydroxytryptamine receptor 6target
DB00458ImipraminePotassium voltage-gated channel subfamily H member 1target
DB00458ImipramineSerum albumincarrier
DB00458ImipramineAlpha-1-acid glycoprotein 2target
DB00186LorazepamUDP-glucuronosyltransferase 2B15enzyme
DB00186LorazepamGABA(A) Receptortarget
DB00186LorazepamCytochrome P450 3A4enzyme
DB00186LorazepamGABA(A) Receptor Benzodiazepine Binding Sitetarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Atarget
DB00370Mirtazapine5HT3 serotonin receptortarget
DB00370MirtazapineAlpha-2A adrenergic receptortarget
DB00370Mirtazapine5-hydroxytryptamine receptor 2Ctarget
DB00370MirtazapineKappa-type opioid receptortarget
DB00370MirtazapineHistamine H1 receptortarget
DB00370MirtazapineCytochrome P450 1A2enzyme
DB00370MirtazapineCytochrome P450 3A4enzyme
DB00370MirtazapineCytochrome P450 2D6enzyme
DB00370MirtazapineAlpha-1 adrenergic receptorstarget
DB00370MirtazapineSodium-dependent serotonin transportertransporter
DB00715ParoxetineSodium-dependent serotonin transportertarget
DB00715ParoxetineSodium-dependent noradrenaline transportertarget
DB00715Paroxetine5-hydroxytryptamine receptor 2Atarget
DB00715ParoxetineCytochrome P450 2D6enzyme
DB00715ParoxetineCytochrome P450 2C9enzyme
DB00715ParoxetineP-glycoprotein 1transporter
DB00715ParoxetineCytochrome P450 2B6enzyme
DB00715ParoxetineCytochrome P450 1A2enzyme
DB00715ParoxetineCytochrome P450 3A4enzyme
DB00715ParoxetineAlpha-1 adrenergic receptorstarget
DB00715ParoxetineAlpha-2 adrenergic receptorstarget
DB00715ParoxetineBeta adrenergic receptortarget
DB00715ParoxetineDopamine D2 receptortarget
DB00715ParoxetineHistamine H1 receptortarget
DB00715ParoxetineSerotonin Receptorstarget
DB00715ParoxetineMuscarinic acetylcholine receptortarget
DB00715Paroxetine5-hydroxytryptamine receptor 2Btarget
DB00715ParoxetineD(1) dopamine receptortarget
DB00715ParoxetineCytochrome P450 2C19enzyme
DB01104SertralineSodium-dependent serotonin transportertarget
DB01104SertralineCytochrome P450 2B6enzyme
DB01104SertralineCytochrome P450 2C19enzyme
DB01104SertralineCytochrome P450 2C9enzyme
DB01104SertralineCytochrome P450 2D6enzyme
DB01104SertralineSodium-dependent dopamine transportertarget
DB01104SertralineCYP2B proteinenzyme
DB01104SertralineCytochrome P450 3A4enzyme
DB01104SertralineAmine oxidase [flavin-containing] Benzyme
DB01104SertralineAmine oxidase [flavin-containing] Aenzyme
DB01104SertralineP-glycoprotein 1transporter
DB01104SertralineSerum albumincarrier
DB01104SertralineSigma receptortarget
DB01104SertralineSodium-dependent noradrenaline transportertarget
DB01104SertralineEquilibrative nucleoside transporter 4target
DB01104SertralineCytochrome P450 2E1enzyme
DB00285VenlafaxineSodium-dependent serotonin transportertarget
DB00285VenlafaxineSodium-dependent noradrenaline transportertarget
DB00285VenlafaxineCytochrome P450 2D6enzyme
DB00285VenlafaxineCytochrome P450 3A4enzyme
DB00285VenlafaxineSodium-dependent dopamine transportertarget
DB00285VenlafaxineP-glycoprotein 1transporter
DB00285VenlafaxineATP-binding cassette sub-family G member 2transporter
DrugDrug NamePhaseStatusCount
DB00715Paroxetine1Completed1
DB00404Alprazolam2Completed1
DB00260Cycloserine2Completed1
DB01202Levetiracetam2Completed1
DB12220ORG-259352Terminated1
DB00715Paroxetine2Terminated1
DB00571Propranolol2Not Yet Recruiting1
DB00734Risperidone2Terminated1
DB01068Clonazepam2 / 3Completed1
DB01104Sertraline2 / 3Completed1
DB13453Xenon2 / 3Not Yet Recruiting1
DB09061Cannabidiol3Not Yet Recruiting1
DB00260Cycloserine3Terminated1
DB15834Lecithin3Not Yet Recruiting1
DB01202Levetiracetam3Completed1
DB00715Paroxetine3Completed2
DB00285Venlafaxine3Completed3
DB00404Alprazolam4Completed3
DB00404Alprazolam4Terminated3
DB01238Aripiprazole4Completed1
DB01068Clonazepam4Completed1
DB00363Clozapine4Completed1
DB00476Duloxetine4Completed1
DB01175Escitalopram4Completed2
DB01175Escitalopram4Recruiting1
DB00422Methylphenidate4Recruiting1
DB00715Paroxetine4Completed5
DB00715Paroxetine4Unknown Status1
DB01224Quetiapine4Completed3
DB00734Risperidone4Completed1
DB01104Sertraline4Completed2
DB01104Sertraline4Terminated1
DB09034Suvorexant4Active Not Recruiting1
DB00313Valproic acid4Completed1
DB09068Vortioxetine4Completed1
DB00246Ziprasidone4Completed1
DB00260CycloserineNot AvailableCompleted1
DB00476DuloxetineNot AvailableActive Not Recruiting1
DB01175EscitalopramNot AvailableTerminated1
DB00472FluoxetineNot AvailableActive Not Recruiting1
DB00458ImipramineNot AvailableCompleted1
DB01064IsoprenalineNot AvailableRecruiting1
DB00715ParoxetineNot AvailableActive Not Recruiting1
DB00715ParoxetineNot AvailableCompleted3
DB00715ParoxetineNot AvailableUnknown Status1
DB01224QuetiapineNot AvailableCompleted1
DB00980RamelteonNot AvailableTerminated1
DB00734RisperidoneNot AvailableCompleted1
DB01104SertralineNot AvailableCompleted3
DB00285VenlafaxineNot AvailableActive Not Recruiting1