Severe Ulcerative Colitis

Drug	Drug Name	Drug Description
DB00091	Cyclosporine	A steroid-sparing immunosuppressant used in organ and bone marrow transplants as well as inflammatory conditions such as ulcerative colitis, rheumatoid arthritis, and atopic dermatitis.
DB06674	Golimumab	A TNFα inhibitor used in the symptomatic treatment of various active inflammatory disorders, such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis.
DB00795	Sulfasalazine	A salicylate used to treat Crohn's disease, ulcerative colitis, and rheumatoid arthritis.

Drug	Drug Name	Target	Type
DB00091	Cyclosporine	Calcium signal-modulating cyclophilin ligand	target
DB00091	Cyclosporine	Peptidyl-prolyl cis-trans isomerase A	target
DB00091	Cyclosporine	Calcineurin subunit B type 2	target
DB00091	Cyclosporine	Cytochrome P450 3A5	enzyme
DB00091	Cyclosporine	Cytochrome P450 3A4	enzyme
DB00091	Cyclosporine	P-glycoprotein 1	transporter
DB00091	Cyclosporine	Bile salt export pump	transporter
DB00091	Cyclosporine	Ileal sodium/bile acid cotransporter	transporter
DB00091	Cyclosporine	Sodium/bile acid cotransporter	transporter
DB00091	Cyclosporine	Solute carrier family 22 member 6	transporter
DB00091	Cyclosporine	Multidrug resistance-associated protein 7	transporter
DB00091	Cyclosporine	Canalicular multispecific organic anion transporter 1	transporter
DB00091	Cyclosporine	ATP-binding cassette sub-family G member 2	transporter
DB00091	Cyclosporine	Solute carrier organic anion transporter family member 1B1	transporter
DB00091	Cyclosporine	Cytochrome P450 2C19	enzyme
DB00091	Cyclosporine	Cytochrome P450 2D6	enzyme
DB00091	Cyclosporine	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	target
DB00091	Cyclosporine	Solute carrier organic anion transporter family member 1B3	transporter
DB06674	Golimumab	Tumor necrosis factor	target
DB00795	Sulfasalazine	Acetyl-CoA acetyltransferase, mitochondrial	target
DB00795	Sulfasalazine	ATP-binding cassette sub-family G member 2	transporter
DB00795	Sulfasalazine	Canalicular multispecific organic anion transporter 1	transporter
DB00795	Sulfasalazine	Prostaglandin G/H synthase 2	target
DB00795	Sulfasalazine	Prostaglandin G/H synthase 1	target
DB00795	Sulfasalazine	Arachidonate 5-lipoxygenase	target
DB00795	Sulfasalazine	Proton-coupled folate transporter	transporter
DB00795	Sulfasalazine	Phospholipase A2	target
DB00795	Sulfasalazine	Solute carrier organic anion transporter family member 1B1	transporter
DB00795	Sulfasalazine	Solute carrier organic anion transporter family member 1B3	transporter
DB00795	Sulfasalazine	Solute carrier organic anion transporter family member 2B1	transporter
DB00795	Sulfasalazine	Serum albumin	carrier
DB00795	Sulfasalazine	Cystine/glutamate transporter	target
DB00795	Sulfasalazine	Nuclear factor NF-kappa-B p105 subunit	target
DB00795	Sulfasalazine	Nuclear factor NF-kappa-B p100 subunit	target
DB00795	Sulfasalazine	Inhibitor of nuclear factor kappa-B kinase subunit beta	target
DB00795	Sulfasalazine	Inhibitor of nuclear factor kappa-B kinase subunit alpha	target
DB00795	Sulfasalazine	Peroxisome proliferator-activated receptor gamma	target
DB00795	Sulfasalazine	Sodium/bile acid cotransporter	transporter

Drug	Drug Name	Phase	Status	Count
DB12053	Visilizumab	1 / 2	Completed	1