Hereditary Angioedema (HAE)

Also known as: Angio Edema Hereditary / HAE / Hereditary Angioedema, HAE / Angioedema, Hereditary / Angioedemas, Hereditary / Hereditary Angioedema / Hereditary Angioedemas / Hereditary angioedema C1 inhibitor deficiency / Hereditary angioneurotic edema (disorder) / C1 esterase inhibitor deficiency

Drug	Drug Name	Drug Description
DB01406	Danazol	A synthetic steroid and pituitary gonadotropin inhibitor used in the treatment of endometriosis and symptomatic treatment of severe pain and tenderness associated with benign fibrocystic breasts.
DB14597	Lanadelumab	A monoclonal antibody targeted against kallikrein which is used to treat attacks of hereditary angioedema.
DB06718	Stanozolol	An anabolic steroid used to manage hereditary angioedema.
DB00302	Tranexamic acid	An antifibrinolytic used to reduce or prevent hemorrhagic episodes, especially in the context of hyperfibrinolytic disorders.

Drug	Drug Name	Target	Type
DB01406	Danazol	Estrogen receptor alpha	target
DB01406	Danazol	Gonadotropin-releasing hormone receptor	target
DB01406	Danazol	Putative gonadotropin-releasing hormone II receptor	target
DB01406	Danazol	Sex hormone-binding globulin	carrier
DB01406	Danazol	C-C motif chemokine 2	target
DB01406	Danazol	Cytochrome P450 19A1	enzyme
DB01406	Danazol	Androgen receptor	target
DB01406	Danazol	Progesterone receptor	target
DB01406	Danazol	Cytochrome P450 3A4	enzyme
DB14597	Lanadelumab	Plasma kallikrein	target
DB06718	Stanozolol	Glucocorticoid binding proteins	target
DB06718	Stanozolol	Androgen receptor	target
DB00302	Tranexamic acid	Plasminogen	target

Drug	Drug Name	Phase	Status	Count
DB12120	Avoralstat	1	Completed	2
DB15982	Berotralstat	1	Completed	4
DB00091	Cyclosporine	1	Completed	1
DB00390	Digoxin	1	Completed	1
DB06196	Icatibant	1	Completed	1
DB14597	Lanadelumab	1	Completed	2
DB01098	Rosuvastatin	1	Completed	1
DB18305	Sebetralstat	1	Completed	1
DB17597	NTLA-2002	1 / 2	Active Not Recruiting	1
DB12120	Avoralstat	2	Completed	1
DB15982	Berotralstat	2	Completed	2
DB09228	Conestat alfa	2	Completed	3
DB18303	Deucrictibant	2	Active Not Recruiting	1
DB18303	Deucrictibant	2	Completed	1
DB05311	Ecallantide	2	Completed	1
DB15629	Garadacimab	2	Completed	1
DB06404	Human C1-esterase inhibitor	2	Completed	4
DB06205	Hyaluronidase (human recombinant)	2	Completed	2
DB18305	Sebetralstat	2	Completed	1
DB12120	Avoralstat	2 / 3	Completed	1
DB15982	Berotralstat	2 / 3	Completed	1
DB09228	Conestat alfa	2 / 3	Completed	1
DB18303	Deucrictibant	2 / 3	Recruiting	1
DB05311	Ecallantide	2 / 3	Withdrawn	1
DB06404	Human C1-esterase inhibitor	2 / 3	Completed	1
DB06404	Human C1-esterase inhibitor	2 / 3	Withdrawn	1
DB12120	Avoralstat	3	Terminated	1
DB15982	Berotralstat	3	Active Not Recruiting	2
DB15982	Berotralstat	3	Completed	2
DB09228	Conestat alfa	3	Completed	1
DB05311	Ecallantide	3	Completed	3
DB15629	Garadacimab	3	Active Not Recruiting	1
DB15629	Garadacimab	3	Completed	1
DB15629	Garadacimab	3	Recruiting	1
DB06404	Human C1-esterase inhibitor	3	Completed	4
DB06196	Icatibant	3	Completed	6
DB16956	L-Acetylleucine	3	Completed	2
DB14597	Lanadelumab	3	Completed	6
DB00936	Salicylic acid	3	Completed	1
DB18305	Sebetralstat	3	Completed	1
DB18305	Sebetralstat	3	Recruiting	2
DB00302	Tranexamic acid	3	Completed	1
DB06404	Human C1-esterase inhibitor	4	Completed	1
DB06196	Icatibant	4	Completed	1
DB15982	Berotralstat	Not Available	Approved for Marketing	1
DB09228	Conestat alfa	Not Available	Completed	1
DB09228	Conestat alfa	Not Available	Recruiting	1
DB05311	Ecallantide	Not Available	Completed	1
DB06196	Icatibant	Not Available	Completed	1
DB06196	Icatibant	Not Available	Recruiting	1
DB14597	Lanadelumab	Not Available	No Longer Available	1
DB14597	Lanadelumab	Not Available	Recruiting	1