Granulomatosis With Polyangiitis

Also known as: Granulomatosis With Polyangitis / Granulomatosis With Polyangiitis (Wegener's Disease) / Wegener Granulomatosis / Wegener's Granulomatosis / Wegener Granulomatosis (WG) / Wegener’s Granulomatosis / Granulomatosis With Polyangiitis (GPA) / Granulomatosis, Wegener's / Polyangiitis, Granulomatosis With / Wegeners Granulomatosis / Granulomatosis With Polyangiitis (Wegener's Granulomatosis) / Granulomatosis With Polyangiitis (Wegener's) / Wegeners Granulomatosis (Granulomatosis With Polyangiitis) / Granulomatosis With Polyangiitis (Wegener's) (GPA) / Wegener's granulomatosis without renal involvement / Granulomatous polyangiitis / Wegener's granulomatosis (disorder)

Drug	Drug Name	Drug Description
DB15011	Avacopan	An orally bioavailable complement 5a receptor (C5aR) antagonist for the treatment of severe anti-neutrophil cytoplasmic (auto)antibody (ANCA)-associated vasculitis.
DB00073	Rituximab	A monoclonal anti-CD20 antibody used to treat non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Wegener's granulomatosis, pemphigus vulgaris, and rheumatoid arthritis.

Drug	Drug Name	Target	Type
DB15011	Avacopan	C5a anaphylatoxin chemotactic receptor 1	target
DB15011	Avacopan	Cytochrome P450 3A4	enzyme
DB15011	Avacopan	ATP-dependent translocase ABCB1	transporter
DB15011	Avacopan	Cytochrome P450 1A2	enzyme
DB15011	Avacopan	Cytochrome P450 2B6	enzyme
DB15011	Avacopan	Cytochrome P450 2C9	enzyme
DB00073	Rituximab	B-lymphocyte antigen CD20	target

Drug	Drug Name	Phase	Status	Count
DB06612	Mepolizumab	0	Not Yet Recruiting	1
DB00531	Cyclophosphamide	1	Recruiting	1
DB01073	Fludarabine	1	Recruiting	1
DB12880	Interleukin-10	1	Completed	1
DB00688	Mycophenolate mofetil	1	Completed	1
DB00073	Rituximab	1	Completed	1
DB00073	Rituximab	1	Recruiting	1
DB01281	Abatacept	1 / 2	Completed	1
DB01015	Sulfamethoxazole	1 / 2	Active Not Recruiting	1
DB00440	Trimethoprim	1 / 2	Active Not Recruiting	1
DB01281	Abatacept	2	Not Yet Recruiting	1
DB00993	Azathioprine	2	Completed	1
DB08879	Belimumab	2	Active Not Recruiting	1
DB12330	Blisibimod	2	Withdrawn	1
DB00531	Cyclophosphamide	2	Completed	2
DB00531	Cyclophosphamide	2	Unknown Status	1
DB00111	Daclizumab	2	Completed	1
DB00005	Etanercept	2	Completed	1
DB12692	Gusperimus	2	Completed	1
DB00065	Infliximab	2	Completed	1
DB00563	Methotrexate	2	Completed	1
DB00563	Methotrexate	2	Unknown Status	1
DB00959	Methylprednisolone	2	Completed	1
DB00688	Mycophenolate mofetil	2	Completed	2
DB00704	Naltrexone	2	Recruiting	1
DB08935	Obinutuzumab	2	Terminated	1
DB00860	Prednisolone	2	Active Not Recruiting	1
DB00860	Prednisolone	2	Completed	1
DB00635	Prednisone	2	Active Not Recruiting	1
DB00635	Prednisone	2	Completed	2
DB00073	Rituximab	2	Active Not Recruiting	1
DB00073	Rituximab	2	Completed	1
DB00073	Rituximab	2	Not Yet Recruiting	1
DB00073	Rituximab	2	Terminated	1
DB06273	Tocilizumab	2	Not Yet Recruiting	1
DB16416	Vilobelimab	2	Completed	1
DB16416	Vilobelimab	2	Terminated	1
DB00993	Azathioprine	2 / 3	Completed	1
DB00531	Cyclophosphamide	2 / 3	Completed	2
DB00005	Etanercept	2 / 3	Completed	1
DB00959	Methylprednisolone	2 / 3	Completed	1
DB00860	Prednisolone	2 / 3	Terminated	1
DB00635	Prednisone	2 / 3	Completed	1
DB00073	Rituximab	2 / 3	Completed	1
DB00936	Salicylic acid	2 / 3	Completed	1
DB01281	Abatacept	3	Completed	1
DB00630	Alendronic acid	3	Completed	1
DB01436	Alfacalcidol	3	Completed	1
DB00993	Azathioprine	3	Completed	2
DB00993	Azathioprine	3	Terminated	1
DB11105	Benzalkonium	3	Completed	1
DB00531	Cyclophosphamide	3	Completed	1
DB00531	Cyclophosphamide	3	Terminated	1
DB12692	Gusperimus	3	Terminated	1
DB00563	Methotrexate	3	Terminated	1
DB00688	Mycophenolate mofetil	3	Completed	1
DB00635	Prednisone	3	Active Not Recruiting	2
DB00073	Rituximab	3	Completed	3
DB11094	Vitamin D	3	Completed	1
DB00087	Alemtuzumab	4	Unknown Status	1
DB00993	Azathioprine	4	Completed	1
DB00531	Cyclophosphamide	4	Completed	1
DB01611	Hydroxychloroquine	4	Active Not Recruiting	1
DB00563	Methotrexate	4	Completed	1
DB00563	Methotrexate	4	Recruiting	1
DB00959	Methylprednisolone	4	Completed	1
DB00688	Mycophenolate mofetil	4	Completed	1
DB00860	Prednisolone	4	Active Not Recruiting	1
DB00635	Prednisone	4	Completed	2
DB00073	Rituximab	4	Active Not Recruiting	1
DB00073	Rituximab	4	Completed	1
DB00073	Rituximab	4	Terminated	1
DB08895	Tofacitinib	4	Recruiting	1
DB00531	Cyclophosphamide	Not Available	Unknown Status	1
DB00091	Cyclosporine	Not Available	Unknown Status	1
DB00099	Filgrastim	Not Available	Unknown Status	1
DB00065	Infliximab	Not Available	Completed	1
DB00959	Methylprednisolone	Not Available	Unknown Status	1
DB00635	Prednisone	Not Available	Recruiting	1
DB00635	Prednisone	Not Available	Unknown Status	1
DB00073	Rituximab	Not Available	Completed	2
DB10805	Yellow fever vaccine	Not Available	Completed	1