Advanced Ovarian Cancer

Also known as: Ovarian Cancer Stage IV / Stage IV Ovarian Cancer / Ovarian cancer metastatic / Ovarian epithelial cancer stage IV / Ovarian epithelial cancer metastatic

DrugDrug NameDrug Description
DB00441GemcitabineA nucleoside metabolic inhibitor used as adjunct therapy in the treatment of certain types of ovarian cancer, non-small cell lung carcinoma, metastatic breast cancer, and as a single agent for pancreatic cancer.
DB00526OxaliplatinA platinum based chemotherapy agent used to treat carcinoma of the colon or rectum or stage III colon cancer.
DB01229PaclitaxelA taxoid chemotherapeutic agent used as first-line and subsequent therapy for the treatment of advanced carcinoma of the ovary, and other various cancers including breast and lung cancer.
DB12332RucaparibAn anti-cancer agent used to treat recurrent ovarian, fallopian tube, or peritoneal cancer.
DrugDrug NameTargetType
DB00441GemcitabineRibonucleoside-diphosphate reductase large subunittarget
DB00441GemcitabineUMP-CMP kinasetarget
DB00441GemcitabineThymidylate synthasetarget
DB00441GemcitabineCytidine deaminaseenzyme
DB00441GemcitabineDeoxycytidine kinaseenzyme
DB00441GemcitabineP-glycoprotein 1transporter
DB00441GemcitabineMultidrug resistance-associated protein 7transporter
DB00441GemcitabineEquilibrative nucleoside transporter 1transporter
DB00441GemcitabineDNAtarget
DB00441GemcitabineSodium/nucleoside cotransporter 1transporter
DB00441GemcitabineEquilibrative nucleoside transporter 2transporter
DB00441GemcitabineSolute carrier family 28 member 3transporter
DB00441GemcitabineThymidine kinase 2, mitochondrialenzyme
DB00441GemcitabineUMP-CMP kinaseenzyme
DB00441GemcitabineNucleoside diphosphate kinase Aenzyme
DB00526OxaliplatinDNAtarget
DB00526OxaliplatinSolute carrier family 22 member 2transporter
DB00526OxaliplatinHigh affinity copper uptake protein 1transporter
DB00526OxaliplatinSolute carrier family 22 member 3transporter
DB00526OxaliplatinATP-binding cassette sub-family G member 2transporter
DB00526OxaliplatinGlutathione S-transferase theta-1enzyme
DB00526OxaliplatinMetallothionein-1Aenzyme
DB00526OxaliplatinMetallothionein-2enzyme
DB00526OxaliplatinMyeloperoxidaseenzyme
DB00526OxaliplatinSuperoxide dismutase [Cu-Zn]enzyme
DB00526OxaliplatinGlutathione S-transferase Penzyme
DB00526OxaliplatinGlutathione S-transferase Mu 1enzyme
DB00526OxaliplatinNAD(P)H dehydrogenase [quinone] 1enzyme
DB00526OxaliplatinCanalicular multispecific organic anion transporter 1transporter
DB00526OxaliplatinCopper-transporting ATPase 2transporter
DB00526OxaliplatinCopper-transporting ATPase 1transporter
DB01229PaclitaxelApoptosis regulator Bcl-2target
DB01229PaclitaxelTubulin beta-1 chaintarget
DB01229PaclitaxelCytochrome P450 2C8enzyme
DB01229PaclitaxelCytochrome P450 3A4enzyme
DB01229PaclitaxelCytochrome P450 3A5enzyme
DB01229PaclitaxelCytochrome P450 3A7enzyme
DB01229PaclitaxelBile salt export pumptransporter
DB01229PaclitaxelP-glycoprotein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 1transporter
DB01229PaclitaxelMultidrug resistance-associated protein 7transporter
DB01229PaclitaxelCytochrome P450 19A1enzyme
DB01229PaclitaxelCytochrome P450 1B1enzyme
DB01229PaclitaxelSolute carrier organic anion transporter family member 1B3transporter
DB01229PaclitaxelNuclear receptor subfamily 1 group I member 2target
DB01229PaclitaxelMicrotubule-associated protein 4target
DB01229PaclitaxelMicrotubule-associated protein 2target
DB01229PaclitaxelMicrotubule-associated protein tautarget
DB01229PaclitaxelCanalicular multispecific organic anion transporter 1transporter
DB12332RucaparibPoly [ADP-ribose] polymerase 1target
DB12332RucaparibPoly [ADP-ribose] polymerase 2target
DB12332RucaparibPoly [ADP-ribose] polymerase 3target
DB12332RucaparibCytochrome P450 2D6enzyme
DB12332RucaparibCytochrome P450 1A2enzyme
DB12332RucaparibCytochrome P450 3A4enzyme
DB12332RucaparibP-glycoprotein 1transporter
DB12332RucaparibATP-binding cassette sub-family G member 2transporter
DB12332RucaparibMultidrug and toxin extrusion protein 1transporter
DB12332RucaparibMultidrug and toxin extrusion protein 2transporter
DB12332RucaparibSolute carrier family 22 member 1transporter
DB12332RucaparibMultidrug resistance-associated protein 4transporter
DB12332RucaparibSolute carrier organic anion transporter family member 1B1transporter
DB12332RucaparibSolute carrier organic anion transporter family member 1B3transporter
DB12332RucaparibSolute carrier family 22 member 6transporter
DB12332RucaparibSolute carrier family 22 member 8transporter
DB12332RucaparibCytochrome P450 3A5enzyme
DB12332RucaparibCytochrome P450 3A7enzyme
DB12332RucaparibCytochrome P450 3A43enzyme
DB12332RucaparibCytochrome P450 2C19enzyme
DB12332RucaparibCytochrome P450 2C9enzyme
DB12332RucaparibCytochrome P450 2C8enzyme
DB12332RucaparibUDP-glucuronosyltransferase 1-1enzyme
DrugDrug NamePhaseStatusCount
DB00062Albumin human0Completed1
DB00693Fluorescein0Active Not Recruiting1
DB00158Folic acid0Active Not Recruiting1
DB00877Sirolimus0Completed1
DB00041Aldesleukin1Completed1
DB00041Aldesleukin1Withdrawn1
DB00126Ascorbic acid1Completed1
DB11595Atezolizumab1Terminated1
DB00958Carboplatin1Active Not Recruiting1
DB00958Carboplatin1Completed2
DB04849Cediranib1Completed1
DB00515Cisplatin1Completed1
DB00531Cyclophosphamide1Completed2
DB01248Docetaxel1Completed1
DB14491Ferrous fumarate1Completed1
DB00099Filgrastim1Completed1
DB01073Fludarabine1Completed1
DB00158Folic acid1Completed1
DB00142Glutamic acid1Completed1
DB15763Iron polymaltose1Completed1
DB16541Lactobacillus casei1Completed1
DB00075Muromonab1Withdrawn1
DB09074Olaparib1Active Not Recruiting1
DB04964Oregovomab1Terminated1
DB01229Paclitaxel1Active Not Recruiting1
DB01229Paclitaxel1Completed3
DB13809Paclitaxel poliglumex1Completed1
DB00019Pegfilgrastim1Completed1
DB11870RG-47331Completed1
DB15151RO-68708101Terminated1
DB15185Rasdegafusp alfa1Completed1
DB00020Sargramostim1Withdrawn1
DB00877Sirolimus1Completed1
DB00877Sirolimus1Withdrawn1
DB11760Talazoparib1Withdrawn1
DB00112Bevacizumab1 / 2Recruiting1
DB00958Carboplatin1 / 2Completed1
DB00958Carboplatin1 / 2Recruiting2
DB00958Carboplatin1 / 2Unknown Status1
DB01259Lapatinib1 / 2Completed1
DB05940Olaparib1 / 2Unknown Status1
DB09074Olaparib1 / 2Unknown Status1
DB04964Oregovomab1 / 2Recruiting1
DB01229Paclitaxel1 / 2Completed1
DB01229Paclitaxel1 / 2Recruiting2
DB01229Paclitaxel1 / 2Unknown Status1
DB09037Pembrolizumab1 / 2Recruiting1
DB11760Talazoparib1 / 2Completed1
DB160632X-1212Recruiting1
DB05015Belinostat2Completed1
DB00112Bevacizumab2Active Not Recruiting1
DB00112Bevacizumab2Completed3
DB00112Bevacizumab2Not Yet Recruiting1
DB00958Carboplatin2Completed3
DB00958Carboplatin2Recruiting2
DB00958Carboplatin2Terminated1
DB00515Cisplatin2Recruiting1
DB00531Cyclophosphamide2Completed1
DB01248Docetaxel2Completed1
DB00997Doxorubicin2Active Not Recruiting1
DB11714Durvalumab2Recruiting1
DB00825Levomenthol2Completed2
DB09074Olaparib2Active Not Recruiting1
DB01229Paclitaxel2Completed3
DB01229Paclitaxel2Recruiting1
DB01229Paclitaxel2Terminated1
DB09037Pembrolizumab2Active Not Recruiting1
DB11870RG-47332Completed1
DB00877Sirolimus2Completed2
DB06287Temsirolimus2Completed2
DB15101Tigatuzumab2Completed1
DB11771Tremelimumab2Recruiting1
DB00112Bevacizumab3Completed1
DB00112Bevacizumab3Recruiting1
DB00958Carboplatin3Completed3
DB00958Carboplatin3Recruiting2
DB00997Doxorubicin3Completed1
DB11714Durvalumab3Recruiting1
DB00441Gemcitabine3Completed1
DB00143Glutathione3Completed1
DB09074Olaparib3Active Not Recruiting1
DB09074Olaparib3Recruiting1
DB01229Paclitaxel3Completed3
DB01229Paclitaxel3Recruiting2
DB00296Ropivacaine3Recruiting1
DB01030Topotecan3Completed1
DB00673AprepitantNot AvailableTerminated1
DB00958CarboplatinNot AvailableTerminated1
DB14547Chloride ionNot AvailableTerminated1
DB00515CisplatinNot AvailableTerminated1
DB00531CyclophosphamideNot AvailableWithdrawn1
DB01234DexamethasoneNot AvailableTerminated1
DB00889GranisetronNot AvailableTerminated1
DB04964OregovomabNot AvailableWithdrawn1
DB12257PlatinumNot AvailableTerminated1
DB00302Tranexamic acidNot AvailableRecruiting1