Traveler's Diarrhea

Also known as: Acute Gastroenteritis in Adult Travelers / Traveller's diarrhea / Traveller's diarrhoea / Travellers' diarrhoea / Traveler's diarrhea (disorder) / Diarrhoea: [infectious] or [travellers] / Dysentery NOS / Infectious diarrheal disease (disorder) / Infectious diarrhea / Dysentery / Dysentery (disorder) / (Specific GIT infectious disease) or (dysentery) or (bacterial: [gastroenteritis] or [diarrhoea]) / Dysyntery / Diarrhoea infectious / Infective diarrhea (disorder) / Infectious: [intestinal disease NOS] or [diarrhoea NOS] / Diarrhea infectious / Infectious diarrhea NOS (disorder) / Infectious diarrhoea NOS / Infectious diarrhoea

DrugDrug NameDrug Description
DB00207AzithromycinA macrolide antibiotic used to treat a variety of bacterial infections.
DB01294Bismuth subsalicylateAn antidiarrheal and anti-inflammatory agent used for symptomatic treatment of nausea, indigestion, upset stomach, diarrhea, and other temporary discomforts of the stomach and gastrointestinal tract.
DB00836LoperamideA long acting antidiarrheal used to control nonspecific diarrhea and chronic diarrhea caused by inflammatory bowel disease, or gastroenteritis.
DB01059NorfloxacinA broad-spectrum fluoroquinolone antibiotic with variable activity against gram-positive and gram-negative bacteria. Typically reserved for the treatment of UTIs due to accumulation in the urine.
DB01165OfloxacinAn antibacterial agent used for the treatment of bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.
DB01220RifaximinA rifamycin-based non-systemic antibiotic used for the treatment of gastrointestinal bacterial infections, such as traveler's diarrhea and irritable bowel syndrome, and reduction of overt hepatic encephalopathy recurrence in adults.
DrugDrug NameTargetType
DB00207Azithromycin23S ribosomal RNAtarget
DB00207AzithromycinP-glycoprotein 1transporter
DB00207AzithromycinCytochrome P450 3A4enzyme
DB00207AzithromycinProtein-arginine deiminase type-4target
DB00207AzithromycinCanalicular multispecific organic anion transporter 1transporter
DB01294Bismuth subsalicylateSerum albumincarrier
DB01294Bismuth subsalicylateSerotransferrincarrier
DB00836LoperamideVoltage-dependent P/Q-type calcium channel subunit alpha-1Atarget
DB00836LoperamideMu-type opioid receptortarget
DB00836LoperamideCalmodulintarget
DB00836LoperamidePro-opiomelanocortintarget
DB00836LoperamideDelta-type opioid receptortarget
DB00836LoperamideCytochrome P450 3A4enzyme
DB00836LoperamideP-glycoprotein 1transporter
DB00836LoperamideKappa-type opioid receptortarget
DB00836LoperamideCytochrome P450 2C8enzyme
DB00836LoperamideCytochrome P450 2B6enzyme
DB00836LoperamideCytochrome P450 2D6enzyme
DB00836LoperamideNuclear receptor subfamily 1 group I member 3target
DB01059NorfloxacinDNA gyrase subunit Atarget
DB01059NorfloxacinDNA topoisomerase 4 subunit Atarget
DB01059NorfloxacinDNA topoisomerase 2-alphatarget
DB01059NorfloxacinCytochrome P450 1A2enzyme
DB01059NorfloxacinCytochrome P450 3A4enzyme
DB01059NorfloxacinSolute carrier family 22 member 5transporter
DB01059NorfloxacinSolute carrier family 22 member 6transporter
DB01059NorfloxacinCytochrome P450 1A1enzyme
DB01059NorfloxacinCytochrome P450 3A7enzyme
DB01165OfloxacinDNA gyrase subunit Atarget
DB01165OfloxacinDNA topoisomerase 4 subunit Atarget
DB01165OfloxacinDNA topoisomerase 2-alphatarget
DB01165OfloxacinCytochrome P450 1A2enzyme
DB01165OfloxacinSolute carrier family 22 member 5transporter
DB01165OfloxacinMultidrug resistance-associated protein 1transporter
DB01165OfloxacinSolute carrier family 22 member 6transporter
DB01165OfloxacinCanalicular multispecific organic anion transporter 1transporter
DB01165OfloxacinSolute carrier family 22 member 4transporter
DB01165OfloxacinBile salt export pumptransporter
DB01220RifaximinDNA-directed RNA polymerase subunit betatarget
DB01220RifaximinNuclear receptor subfamily 1 group I member 2target
DB01220RifaximinCytochrome P450 3A4enzyme
DB01220RifaximinCytochrome P450 2C19enzyme
DB01220RifaximinCytochrome P450 2C8enzyme
DrugDrug NamePhaseStatusCount
DB11062Octisalate2Completed1
DB09535Octocrylene2Completed1
DB11753Rifamycin2Not Yet Recruiting2
DB09321Zinc oxide2Completed1
DB01294Bismuth subsalicylate3Recruiting1
DB00537Ciprofloxacin3Completed1
DB11062Octisalate3Withdrawn1
DB09535Octocrylene3Withdrawn1
DB11892Prulifloxacin3Completed1
DB05378Rifamycin3Completed2
DB01220Rifaximin3Terminated1
DB09321Zinc oxide3Withdrawn1
DB00836Loperamide4Completed1
DB01220Rifaximin4Completed1
DB01220Rifaximin4Withdrawn1
DB01220RifaximinNot AvailableActive Not Recruiting1