Pre-Exposure Prophylaxis

Also known as: Pre-Exposure Prophylaxis (PrEP) / Preexposure Prophylaxis / Pre Exposure Prophylaxis / Preexposure Prophylaxis (PrEP) / Pre-exposure prophylaxis (procedure)

Drug	Drug Name	Drug Description
DB16393	Cilgavimab	An extended half-life recombinant monoclonal IgG1κ antibody directed against the SARS-CoV-2 S protein for COVID-19 prophylaxis in individuals unable to undergo COVID-19 immunization.
DB00879	Emtricitabine	A nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV.
DB09299	Tenofovir alafenamide	A nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease.
DB16394	Tixagevimab	An extended half-life recombinant monoclonal IgG1κ antibody directed against the SARS-CoV-2 S protein for COVID-19 prophylaxis in individuals unable to undergo COVID-19 immunization.

Drug	Drug Name	Target	Type
DB16393	Cilgavimab	Spike glycoprotein	target
DB00879	Emtricitabine	Reverse transcriptase/RNaseH	target
DB00879	Emtricitabine	Deoxycytidine kinase	enzyme
DB00879	Emtricitabine	Serum albumin	carrier
DB00879	Emtricitabine	Multidrug and toxin extrusion protein 1	transporter
DB09299	Tenofovir alafenamide	Reverse transcriptase/RNaseH	target
DB09299	Tenofovir alafenamide	P-glycoprotein 1	transporter
DB09299	Tenofovir alafenamide	Multidrug resistance-associated protein 4	transporter
DB09299	Tenofovir alafenamide	Solute carrier family 22 member 6	transporter
DB09299	Tenofovir alafenamide	Solute carrier family 22 member 8	transporter
DB09299	Tenofovir alafenamide	Lysosomal protective protein	enzyme
DB09299	Tenofovir alafenamide	Liver carboxylesterase 1	enzyme
DB09299	Tenofovir alafenamide	ATP-binding cassette sub-family G member 2	transporter
DB09299	Tenofovir alafenamide	Solute carrier organic anion transporter family member 1B1	transporter
DB09299	Tenofovir alafenamide	Solute carrier organic anion transporter family member 1B3	transporter
DB09299	Tenofovir alafenamide	Reverse transcriptase	target
DB09299	Tenofovir alafenamide	DNA polymerase	target
DB09299	Tenofovir alafenamide	Serum albumin	carrier
DB09299	Tenofovir alafenamide	Cytochrome P450 3A4	enzyme
DB09299	Tenofovir alafenamide	Adenylate kinase isoenzyme 1	enzyme
DB09299	Tenofovir alafenamide	Adenylate kinase 2, mitochondrial	enzyme
DB09299	Tenofovir alafenamide	Nucleoside diphosphate kinase A	enzyme
DB09299	Tenofovir alafenamide	Nucleoside diphosphate kinase B	enzyme
DB16394	Tixagevimab	Spike glycoprotein	target

Drug	Drug Name	Phase	Status	Count
DB00879	Emtricitabine	0	Completed	1
DB01032	Probenecid	0	Completed	1
DB00300	Tenofovir disoproxil	0	Completed	1
DB10283	Rabies virus inactivated antigen, A	2	Completed	1
DB11799	Bictegravir	3	Recruiting	1
DB00879	Emtricitabine	3	Recruiting	1
DB01611	Hydroxychloroquine	3	Terminated	1
DB09299	Tenofovir alafenamide	3	Recruiting	1
DB00300	Tenofovir disoproxil	3	Recruiting	1
DB11751	Cabotegravir	4	Recruiting	1
DB00879	Emtricitabine	4	Completed	3
DB00300	Tenofovir disoproxil	4	Completed	3
DB00879	Emtricitabine	Not Available	Not Yet Recruiting	1
DB00879	Emtricitabine	Not Available	Recruiting	1
DB00709	Lamivudine	Not Available	Not Yet Recruiting	1
DB09299	Tenofovir alafenamide	Not Available	Recruiting	1
DB00300	Tenofovir disoproxil	Not Available	Not Yet Recruiting	1
DB00300	Tenofovir disoproxil	Not Available	Recruiting	1