Metastatic Castration-Resistant Prostate Cancer (mCRPC)

Also known as: Metastatic Castrate-resistant Prostate (CRPC) Cancer / Hormone-refractory prostate cancer metastatic / Castrate Refractory Metastatic Prostate Cancer (mCRPC) / Metastatic Castration-Resistant Prostate Cancer / Castration resistant, metastatic Prostate Cancer / Metastatic Castration Resistant Prostate Cancer / Castration-resistant prostate cancer / Hormone-refractory prostate cancer / Hormone refractory prostate cancer (disorder)

DrugDrug NameDrug Description
DB05812AbirateroneAn antiandrogen used in the treatment of prostate cancer.
DB16778Lutetium Lu-177 vipivotide tetraxetanA radioligand therapeutic agent used to treat prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer in adults.
DB09074OlaparibA poly (ADP-ribose) polymerase (PARP) inhibitor used to treat ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer.
DB00635PrednisoneA corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.
DB08913Radium Ra 223 dichlorideA radiopharmaceutical agent used to treat patients with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease.
DB12332RucaparibA poly (ADP-ribose) polymerase (PARP) inhibitor used to treat recurrent ovarian and prostate cancers in previously treated adults.
DrugDrug NameTargetType
DB05812AbirateroneSteroid 17-alpha-hydroxylase/17,20 lyasetarget
DB05812AbirateroneSerum albumincarrier
DB05812AbirateroneAlpha-1-acid glycoprotein 1carrier
DB05812AbirateroneCytochrome P450 3A4enzyme
DB05812AbirateroneBile salt sulfotransferaseenzyme
DB05812AbirateroneMultidrug resistance-associated protein 1transporter
DB05812AbirateroneCytochrome P450 2D6enzyme
DB05812AbirateroneCytochrome P450 2C8enzyme
DB05812AbirateroneCytochrome P450 1A2enzyme
DB05812AbirateroneCytochrome P450 2C19enzyme
DB05812AbirateroneCytochrome P450 2C9enzyme
DB16778Lutetium Lu-177 vipivotide tetraxetanProstate-specific antigentarget
DB09074OlaparibPoly [ADP-ribose] polymerase 1target
DB09074OlaparibCytochrome P450 3A4enzyme
DB09074OlaparibCytochrome P450 2B6enzyme
DB09074OlaparibPoly [ADP-ribose] polymerase 2target
DB09074OlaparibPoly [ADP-ribose] polymerase 3target
DB09074OlaparibCytochrome P450 3A5enzyme
DB09074OlaparibP-glycoprotein 1transporter
DB09074OlaparibATP-binding cassette sub-family G member 2transporter
DB09074OlaparibAldo-keto reductase family 1 member C3target
DB09074OlaparibUDP-glucuronosyltransferase 1-1enzyme
DB09074OlaparibSerum albumincarrier
DB09074OlaparibAlpha-1-acid glycoprotein 1carrier
DB00635PrednisoneGlucocorticoid receptortarget
DB00635PrednisoneCytochrome P450 3A4enzyme
DB00635PrednisoneP-glycoprotein 1transporter
DB00635PrednisoneSolute carrier organic anion transporter family member 1A2transporter
DB00635PrednisoneCytochrome P450 2C19enzyme
DB00635PrednisoneSerum albumincarrier
DB00635PrednisoneCytochrome P450 3A5enzyme
DB00635PrednisoneCorticosteroid-binding globulincarrier
DB00635PrednisoneCytochrome P450 3A Subfamilyenzyme
DB00635PrednisoneCytochrome P450 2A6enzyme
DB00635PrednisoneCytochrome P450 1B1enzyme
DB00635PrednisoneCytochrome P450 2B6enzyme
DB00635PrednisoneCytochrome P450 2C8enzyme
DB00635PrednisoneCytochrome P450 2C9enzyme
DB00635PrednisoneCorticosteroid 11-beta-dehydrogenase isozyme 1enzyme
DB12332RucaparibPoly [ADP-ribose] polymerase 1target
DB12332RucaparibPoly [ADP-ribose] polymerase 2target
DB12332RucaparibPoly [ADP-ribose] polymerase 3target
DB12332RucaparibCytochrome P450 2D6enzyme
DB12332RucaparibCytochrome P450 1A2enzyme
DB12332RucaparibCytochrome P450 3A4enzyme
DB12332RucaparibP-glycoprotein 1transporter
DB12332RucaparibATP-binding cassette sub-family G member 2transporter
DB12332RucaparibMultidrug and toxin extrusion protein 1transporter
DB12332RucaparibMultidrug and toxin extrusion protein 2transporter
DB12332RucaparibSolute carrier family 22 member 1transporter
DB12332RucaparibMultidrug resistance-associated protein 4transporter
DB12332RucaparibSolute carrier organic anion transporter family member 1B1transporter
DB12332RucaparibSolute carrier organic anion transporter family member 1B3transporter
DB12332RucaparibSolute carrier family 22 member 6transporter
DB12332RucaparibSolute carrier family 22 member 8transporter
DB12332RucaparibCytochrome P450 3A5enzyme
DB12332RucaparibCytochrome P450 3A7enzyme
DB12332RucaparibCytochrome P450 3A43enzyme
DB12332RucaparibCytochrome P450 2C19enzyme
DB12332RucaparibCytochrome P450 2C9enzyme
DB12332RucaparibCytochrome P450 2C8enzyme
DB12332RucaparibUDP-glucuronosyltransferase 1-1enzyme
DrugDrug NamePhaseStatusCount
DB00531Cyclophosphamide0Recruiting1
DB01073Fludarabine0Recruiting1
DB16019Gallium Ga-68 gozetotide0Not Yet Recruiting1
DB16303Gallium-68 PSMA0Not Yet Recruiting1
DB08947Iopamidol0Completed1
DB13982Lutetium Lu-1770Not Yet Recruiting1
DB05812Abiraterone1Active Not Recruiting3
DB05812Abiraterone1Not Yet Recruiting1
DB05812Abiraterone1Recruiting2
DB00026Anakinra1Active Not Recruiting1
DB11901Apalutamide1Active Not Recruiting1
DB11901Apalutamide1Recruiting1
DB11595Atezolizumab1Completed1
DB11595Atezolizumab1Recruiting1
DB11945Avelumab1Recruiting1
DB06626Axitinib1Completed1
DB05015Belinostat1Recruiting1
DB15140Bempegaldesleukin1Completed1
DB11105Benzalkonium1Active Not Recruiting1
DB00112Bevacizumab1Recruiting1
DB06772Cabazitaxel1Completed1
DB08875Cabozantinib1Not Yet Recruiting1
DB12218Capivasertib1Completed1
DB16125Ciforadenant1Active Not Recruiting1
DB16125Ciforadenant1Completed1
DB00531Cyclophosphamide1Active Not Recruiting1
DB12941Darolutamide1Active Not Recruiting1
DB01248Docetaxel1Active Not Recruiting1
DB01248Docetaxel1Recruiting4
DB11714Durvalumab1Active Not Recruiting1
DB08899Enzalutamide1Active Not Recruiting2
DB08899Enzalutamide1Completed2
DB00005Etanercept1Active Not Recruiting1
DB01073Fludarabine1Active Not Recruiting1
DB00947Fulvestrant1Recruiting1
DB17293Hiltonol1Completed1
DB04915Idronoxil1Terminated1
DB16192Imaradenant1Active Not Recruiting1
DB06186Ipilimumab1Recruiting1
DB13982Lutetium Lu-1771Completed1
DB13982Lutetium Lu-1771Recruiting2
DB13982Lutetium Lu-1771Unknown Status1
DB16778Lutetium Lu-177 vipivotide tetraxetan1Not Yet Recruiting1
DB14978MIP-1095 I-1311Completed1
DB00959Methylprednisolone1Recruiting1
DB01204Mitoxantrone1Completed1
DB09035Nivolumab1Active Not Recruiting1
DB06132Nivolumab1Completed1
DB09035Nivolumab1Completed2
DB09035Nivolumab1Recruiting2
DB09074Olaparib1Recruiting1
DB15088Oleclumab1Active Not Recruiting1
DB00019Pegfilgrastim1Completed1
DB09037Pembrolizumab1Active Not Recruiting2
DB16846Pidnarulex1Recruiting1
DB17048Plumbagin1Terminated1
DB00635Prednisone1Active Not Recruiting1
DB00635Prednisone1Completed1
DB00635Prednisone1Recruiting2
DB16065Proxalutamide1Completed1
DB14851Relatlimab1Recruiting1
DB11853Relugolix1Recruiting1
DB04974Rimiducid1Active Not Recruiting1
DB12332Rucaparib1Active Not Recruiting1
DB11760Talazoparib1Recruiting3
DB12887Tazemetostat1Recruiting1
DB16822AZD-50691 / 2Active Not Recruiting1
DB12001Abemaciclib1 / 2Recruiting1
DB05812Abiraterone1 / 2Active Not Recruiting2
DB05812Abiraterone1 / 2Recruiting4
DB05812Abiraterone1 / 2Terminated1
DB11648Afuresertib1 / 2Recruiting1
DB14970Alobresib1 / 2Terminated1
DB11595Atezolizumab1 / 2Recruiting1
DB11945Avelumab1 / 2Terminated1
DB15140Bempegaldesleukin1 / 2Terminated1
DB14581CPI-12051 / 2Active Not Recruiting1
DB06772Cabazitaxel1 / 2Recruiting1
DB00958Carboplatin1 / 2Recruiting1
DB06322Carotuximab1 / 2Completed1
DB14707Cemiplimab1 / 2Recruiting2
DB12483Copanlisib1 / 2Active Not Recruiting1
DB12941Darolutamide1 / 2Recruiting1
DB01234Dexamethasone1 / 2Recruiting1
DB01248Docetaxel1 / 2Recruiting1
DB16153Eltanexor1 / 2Recruiting1
DB08899Enzalutamide1 / 2Active Not Recruiting4
DB05094Enzalutamide1 / 2Completed1
DB08899Enzalutamide1 / 2Completed1
DB08899Enzalutamide1 / 2Recruiting3
DB08899Enzalutamide1 / 2Terminated2
DB00773Etoposide1 / 2Recruiting1
DB16162Exicorilant1 / 2Active Not Recruiting1
DB00099Filgrastim1 / 2Recruiting1
DB09078Lenvatinib1 / 2Recruiting1
DB13982Lutetium Lu-1771 / 2Active Not Recruiting1
DB13982Lutetium Lu-1771 / 2Not Yet Recruiting1
DB13982Lutetium Lu-1771 / 2Recruiting4
DB16778Lutetium Lu-177 vipivotide tetraxetan1 / 2Recruiting1
DB09035Nivolumab1 / 2Recruiting1
DB09074Olaparib1 / 2Recruiting2
DB09074Olaparib1 / 2Terminated1
DB00019Pegfilgrastim1 / 2Recruiting1
DB09037Pembrolizumab1 / 2Active Not Recruiting1
DB09037Pembrolizumab1 / 2Recruiting1
DB00635Prednisone1 / 2Active Not Recruiting1
DB00635Prednisone1 / 2Recruiting2
DB00635Prednisone1 / 2Terminated1
DB14646Prednisone acetate1 / 2Recruiting1
DB12813Radium Ra-2231 / 2Recruiting2
DB15766Retifanlimab1 / 2Active Not Recruiting1
DB04974Rimiducid1 / 2Recruiting1
DB12332Rucaparib1 / 2Active Not Recruiting1
DB11767Sarilumab1 / 2Recruiting1
DB11760Talazoparib1 / 2Terminated1
DB14004Tildrakizumab1 / 2Recruiting1
DB16420Vibostolimab1 / 2Recruiting1
DB12001Abemaciclib2Active Not Recruiting1
DB12001Abemaciclib2Recruiting1
DB05812Abiraterone2Active Not Recruiting3
DB05812Abiraterone2Completed3
DB05812Abiraterone2Recruiting2
DB05812Abiraterone2Terminated2
DB00787Acyclovir2Completed1
DB08916Afatinib2Recruiting1
DB06094Apatorsen2Terminated1
DB11595Atezolizumab2Recruiting1
DB11945Avelumab2Terminated1
DB00112Bevacizumab2Recruiting1
DB05899CRLX1012Terminated1
DB06772Cabazitaxel2Completed1
DB06772Cabazitaxel2Recruiting1
DB06772Cabazitaxel2Withdrawn1
DB01101Capecitabine2Recruiting1
DB00958Carboplatin2Recruiting3
DB08889Carfilzomib2Completed1
DB14917Ceralasertib2Recruiting1
DB11672Curcumin2Terminated1
DB00531Cyclophosphamide2Recruiting1
DB12941Darolutamide2Active Not Recruiting1
DB16410Datopotamab deruxtecan2Recruiting1
DB01234Dexamethasone2Completed1
DB01248Docetaxel2Recruiting2
DB01248Docetaxel2Terminated1
DB01248Docetaxel2Unknown Status1
DB11714Durvalumab2Active Not Recruiting1
DB11714Durvalumab2Recruiting2
DB13007Enfortumab vedotin2Recruiting1
DB08899Enzalutamide2Active Not Recruiting2
DB05094Enzalutamide2Completed1
DB08899Enzalutamide2Completed5
DB08899Enzalutamide2Recruiting6
DB08899Enzalutamide2Terminated2
DB05094Enzalutamide2Withdrawn1
DB08899Enzalutamide2Withdrawn1
DB00099Filgrastim2Withdrawn1
DB13146Fluciclovine (18F)2Recruiting1
DB00544Fluorouracil2Recruiting1
DB15637Fluzoparib2Active Not Recruiting1
DB16019Gallium Ga-68 gozetotide2Not Yet Recruiting1
DB16192Imaradenant2Active Not Recruiting1
DB17120Imifoplatin2Recruiting1
DB06186Ipilimumab2Active Not Recruiting1
DB06186Ipilimumab2Recruiting1
DB00650Leucovorin2Recruiting1
DB13982Lutetium Lu-1772Not Yet Recruiting3
DB13982Lutetium Lu-1772Recruiting3
DB16778Lutetium Lu-177 vipivotide tetraxetan2Not Yet Recruiting1
DB16778Lutetium Lu-177 vipivotide tetraxetan2Terminated1
DB09035Nivolumab2Active Not Recruiting1
DB09035Nivolumab2Recruiting2
DB09074Olaparib2Active Not Recruiting1
DB09074Olaparib2Recruiting5
DB15088Oleclumab2Active Not Recruiting1
DB15110Onvansertib2Active Not Recruiting1
DB14769Pamiparib2Recruiting1
DB14769Pamiparib2Terminated1
DB09037Pembrolizumab2Completed1
DB09037Pembrolizumab2Recruiting1
DB00860Prednisolone2Active Not Recruiting1
DB00635Prednisone2Active Not Recruiting2
DB00635Prednisone2Completed1
DB00635Prednisone2Recruiting1
DB00635Prednisone2Terminated1
DB00635Prednisone2Withdrawn1
DB14646Prednisone acetate2Active Not Recruiting1
DB16065Proxalutamide2Recruiting1
DB12813Radium Ra-2232Unknown Status1
DB14765Rivoceranib2Active Not Recruiting1
DB12332Rucaparib2Completed1
DB11836Sapanisertib2Completed1
DB01037Selegiline2Recruiting1
DB06688Sipuleucel-T2Completed1
DB14892Spartalizumab2Active Not Recruiting1
DB05861Tasquinimod2Terminated1
DB13943Testosterone cypionate2Completed1
DB13943Testosterone cypionate2Recruiting1
DB13944Testosterone enanthate2Completed1
DB13944Testosterone enanthate2Recruiting1
DB13946Testosterone undecanoate2Recruiting1
DB15559Zenocutuzumab2Recruiting1
DB05812Abiraterone3Active Not Recruiting4
DB05812Abiraterone3Completed3
DB05812Abiraterone3Recruiting4
DB06772Cabazitaxel3Recruiting1
DB06772Cabazitaxel3Unknown Status1
DB00958Carboplatin3Recruiting1
DB12941Darolutamide3Terminated1
DB01248Docetaxel3Active Not Recruiting2
DB01248Docetaxel3Completed1
DB01248Docetaxel3Recruiting1
DB01248Docetaxel3Unknown Status1
DB08899Enzalutamide3Active Not Recruiting3
DB08899Enzalutamide3Recruiting3
DB08899Enzalutamide3Terminated1
DB15637Fluzoparib3Recruiting1
DB13982Lutetium Lu-1773Recruiting1
DB11526Masitinib3Completed1
DB11793Niraparib3Recruiting1
DB09074Olaparib3Active Not Recruiting3
DB00860Prednisolone3Active Not Recruiting1
DB00635Prednisone3Completed4
DB00635Prednisone3Recruiting2
DB08913Radium Ra 223 dichloride3Recruiting1
DB08913Radium Ra 223 dichloride3Terminated1
DB12813Radium Ra-2233Terminated1
DB12332Rucaparib3Active Not Recruiting1
DB12332Rucaparib3Enrolling by Invitation1
DB05812Abiraterone4Completed1
DB05812Abiraterone4Recruiting1
DB08899Enzalutamide4Active Not Recruiting1
DB05094Enzalutamide4Completed1
DB08899Enzalutamide4Completed2
DB08899Enzalutamide4Recruiting1
DB08899Enzalutamide4Terminated1
DB09074Olaparib4Recruiting1
DB00860Prednisolone4Completed1
DB00635Prednisone4Recruiting1
DB08913Radium Ra 223 dichloride4Recruiting1
DB05812AbirateroneNot AvailableAvailable1
DB05812AbirateroneNot AvailableCompleted1
DB01248DocetaxelNot AvailableCompleted1
DB05094EnzalutamideNot AvailableApproved for Marketing1
DB08899EnzalutamideNot AvailableApproved for Marketing1
DB08899EnzalutamideNot AvailableCompleted4
DB13982Lutetium Lu-177Not AvailableRecruiting1
DB16778Lutetium Lu-177 vipivotide tetraxetanNot AvailableNo Longer Available1
DB11793NiraparibNot AvailableAvailable1
DB00860PrednisoloneNot AvailableAvailable1
DB00635PrednisoneNot AvailableAvailable1
DB08913Radium Ra 223 dichlorideNot AvailableActive Not Recruiting1
DB09566Radium Ra 223 dichlorideNot AvailableActive Not Recruiting1
DB08913Radium Ra 223 dichlorideNot AvailableCompleted3
DB08913Radium Ra 223 dichlorideNot AvailableRecruiting1
DB12813Radium Ra-223Not AvailableCompleted1
DB06688Sipuleucel-TNot AvailableCompleted1
DB01268SunitinibNot AvailableCompleted1
DB11760TalazoparibNot AvailableAvailable1