First Line Chemotherapy

Also known as: First-line chemotherapy

DrugDrug NameDrug Description
DB11945AvelumabAn anti-PD-L1 monoclonal antibody used to treat metastatic merkel cell carcinoma, metastatic urothelial carcinoma, or renal cell carcinoma.
DB06626AxitinibAn oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.
DB00112BevacizumabA monoclonal anti-vascular endothelial growth factor antibody used in combination with antineoplastic agents for the treatment of many types of cancer.
DB14707CemiplimabA programmed death receptor-1 blocking antibody used to treat cutaneous squamous cell carcinoma, basal cell carcinoma, and non-small cell lung cancer.
DB11714DurvalumabAn antineoplastic monoclonal antibody used to treat urothelial carcinoma and locally advanced, unresectable non-small cell lung cancer.
DB00070Hyaluronidase (ovine)A purified form of sheep hyaluronidase enzyme used as an adjunct in subcutaneous rehydration therapy and to increase absorption of other drugs and radiopaque imaging agents.
DB06186IpilimumabA human cytotoxic T-lymphocyte antigen 4 (CTLA-4) blocking antibody used to treat metastatic or unresectable melanoma.
DB00762IrinotecanA topoisomerase inhibitor used to treat metastatic carcinoma of the colon or rectum and pancreatic adenocarcinoma.
DB09330OsimertinibA tyrosine kinase inhibitor used in the treatment of certain types of non-small cell lung carcinoma.
DB00073RituximabA monoclonal anti-CD20 antibody used to treat non-Hodgkin's lymphoma, chronic lymphocytic leukemia, Wegener's granulomatosis, pemphigus vulgaris, and rheumatoid arthritis.
DrugDrug NameTargetType
DB11945AvelumabProgrammed cell death 1 ligand 1target
DB06626AxitinibVascular endothelial growth factor receptor 1target
DB06626AxitinibVascular endothelial growth factor receptor 2target
DB06626AxitinibVascular endothelial growth factor receptor 3target
DB06626AxitinibCytochrome P450 3A4enzyme
DB06626AxitinibCytochrome P450 3A5enzyme
DB06626AxitinibCytochrome P450 1A2enzyme
DB06626AxitinibCytochrome P450 2C19enzyme
DB06626AxitinibUDP-glucuronosyltransferase 1-1enzyme
DB06626AxitinibP-glycoprotein 1transporter
DB06626AxitinibSolute carrier organic anion transporter family member 1B1transporter
DB00112BevacizumabVascular endothelial growth factor Atarget
DB00112BevacizumabComplement C1q subcomponent subunit Atarget
DB00112BevacizumabComplement C1q subcomponent subunit Btarget
DB00112BevacizumabComplement C1q subcomponent subunit Ctarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor III-Atarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor II-atarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor II-btarget
DB00112BevacizumabLow affinity immunoglobulin gamma Fc region receptor II-ctarget
DB00112BevacizumabHigh affinity immunoglobulin gamma Fc receptor Itarget
DB14707CemiplimabProgrammed cell death protein 1target
DB11714DurvalumabProgrammed cell death 1 ligand 1target
DB11714DurvalumabProgrammed cell death protein 1target
DB00070Hyaluronidase (ovine)Transforming growth factor beta-1target
DB00070Hyaluronidase (ovine)Serum albumincarrier
DB00070Hyaluronidase (ovine)Hyaluronantarget
DB06186IpilimumabCytotoxic T-lymphocyte protein 4target
DB00762IrinotecanDNA topoisomerase I, mitochondrialtarget
DB00762IrinotecanDNA topoisomerase 1target
DB00762IrinotecanCytochrome P450 3A4enzyme
DB00762IrinotecanCytochrome P450 3A5enzyme
DB00762IrinotecanUDP-glucuronosyltransferase 1-1enzyme
DB00762IrinotecanUDP-glucuronosyltransferase 1-9enzyme
DB00762IrinotecanCytochrome P450 3A7enzyme
DB00762IrinotecanSolute carrier family 22 member 3transporter
DB00762IrinotecanSolute carrier organic anion transporter family member 1B1transporter
DB00762IrinotecanMultidrug resistance-associated protein 1transporter
DB00762IrinotecanATP-binding cassette sub-family G member 2transporter
DB00762IrinotecanSerum albumincarrier
DB00762IrinotecanP-glycoprotein 1transporter
DB00762IrinotecanCanalicular multispecific organic anion transporter 1transporter
DB00762IrinotecanHuman Carboxylesterasesenzyme
DB09330OsimertinibEpidermal growth factor receptortarget
DB09330OsimertinibP-glycoprotein 1transporter
DB09330OsimertinibATP-binding cassette sub-family G member 2transporter
DB09330OsimertinibCytochrome P450 3A4enzyme
DB09330OsimertinibCytochrome P450 1A2enzyme
DB00073RituximabB-lymphocyte antigen CD20target
DrugDrug NamePhaseStatusCount
DB01101Capecitabine2Unknown Status1
DB00515Cisplatin2Unknown Status1
DB01229Paclitaxel2Unknown Status1