Human Immunodeficiency Virus Type 1 (HIV-1)

Also known as: Human Immunodeficiency Virus - Type 1 / HIV-I / HIV-1 / Human Immunodeficiency Virus Type 1 / Immunodeficiency Virus Type 1, Human / Human Immunodeficiency Virus-1 / Human Immunodeficiency Virus-1 (HIV-1) / Human Immunodeficiency Virus-Type 1 / Human Immunodeficiency Virus 1 / Human T-cell leukemia virus III / T-lymphotropic virus / Human T-cell leukaemia virus III / T-lymphotropic virus (organism) / Human immunodeficiency virus type 1 [Ambiguous] / Human immunodeficiency virus type I (organism) / Human immunodeficiency virus type I -RETIRED- / [X]Human immunodeficiency virus disease (disorder) / Human immunodeficiency virus [HIV] disease / [X]Unspecified human immunodeficiency virus [HIV] disease (disorder) / HIV disease / (AIDS) or (HIV infection) / HTLV-III/LAV infection -RETIRED- / HIV infection NOS / Human immunodeficiency virus syndrome / Human immunodeficiency virus infection, unspecified / HIV Infections / HIV infection / Human immunodeficiency virus infection (disorder)

Drug	Drug Name	Drug Description
DB12301	Doravirine	A non-nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals to treat HIV-1 infections.
DB00879	Emtricitabine	A nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV.
DB00109	Enfuvirtide	An HIV-1 gp41 fusion inhibitor used in patients experiencing HIV-1 replication who are already being treated with other anti-retrovirals.
DB09299	Tenofovir alafenamide	A nucleoside analog reverse transcriptase inhibitor used for the treatment of chronic hepatitis B virus infection in adults with compensated liver disease.

Drug	Drug Name	Target	Type
DB12301	Doravirine	Cytochrome P450 3A4	enzyme
DB12301	Doravirine	Cytochrome P450 3A5	enzyme
DB12301	Doravirine	Reverse transcriptase/RNaseH	target
DB00879	Emtricitabine	Reverse transcriptase/RNaseH	target
DB00879	Emtricitabine	Deoxycytidine kinase	enzyme
DB00879	Emtricitabine	Serum albumin	carrier
DB00879	Emtricitabine	Multidrug and toxin extrusion protein 1	transporter
DB00109	Enfuvirtide	Envelope glycoprotein	target
DB00109	Enfuvirtide	Cytochrome P450 2C19	enzyme
DB00109	Enfuvirtide	Cytochrome P450 2E1	enzyme
DB09299	Tenofovir alafenamide	Reverse transcriptase/RNaseH	target
DB09299	Tenofovir alafenamide	P-glycoprotein 1	transporter
DB09299	Tenofovir alafenamide	Multidrug resistance-associated protein 4	transporter
DB09299	Tenofovir alafenamide	Solute carrier family 22 member 6	transporter
DB09299	Tenofovir alafenamide	Solute carrier family 22 member 8	transporter
DB09299	Tenofovir alafenamide	Lysosomal protective protein	enzyme
DB09299	Tenofovir alafenamide	Liver carboxylesterase 1	enzyme
DB09299	Tenofovir alafenamide	ATP-binding cassette sub-family G member 2	transporter
DB09299	Tenofovir alafenamide	Solute carrier organic anion transporter family member 1B1	transporter
DB09299	Tenofovir alafenamide	Solute carrier organic anion transporter family member 1B3	transporter
DB09299	Tenofovir alafenamide	Reverse transcriptase	target
DB09299	Tenofovir alafenamide	DNA polymerase	target
DB09299	Tenofovir alafenamide	Serum albumin	carrier
DB09299	Tenofovir alafenamide	Cytochrome P450 3A4	enzyme
DB09299	Tenofovir alafenamide	Adenylate kinase isoenzyme 1	enzyme
DB09299	Tenofovir alafenamide	Adenylate kinase 2, mitochondrial	enzyme
DB09299	Tenofovir alafenamide	Nucleoside diphosphate kinase A	enzyme
DB09299	Tenofovir alafenamide	Nucleoside diphosphate kinase B	enzyme

Drug	Drug Name	Phase	Status	Count
DB01072	Atazanavir	1	Completed	2
DB09065	Cobicistat	1	Completed	1
DB01264	Darunavir	1	Completed	1
DB12301	Doravirine	1	Completed	1
DB15653	Islatravir	1	Completed	1
DB00238	Nevirapine	1	Completed	1
DB05083	Rilpivirine	1	Completed	1
DB08864	Rilpivirine	1	Completed	2
DB05083	Rilpivirine	1	Terminated	1
DB08864	Rilpivirine	1	Terminated	1
DB00503	Ritonavir	1	Completed	1
DB00582	Voriconazole	1	Completed	1
DB08639	Dapivirine	1 / 2	Completed	1
DB01048	Abacavir	2	Recruiting	1
DB01072	Atazanavir	2	Completed	1
DB01264	Darunavir	2	Completed	4
DB00625	Efavirenz	2	Active Not Recruiting	1
DB00625	Efavirenz	2	Completed	2
DB00625	Efavirenz	2	Terminated	1
DB09101	Elvitegravir	2	Completed	1
DB00879	Emtricitabine	2	Active Not Recruiting	1
DB00879	Emtricitabine	2	Completed	3
DB00879	Emtricitabine	2	Recruiting	1
DB00109	Enfuvirtide	2	Completed	1
DB06414	Etravirine	2	Completed	3
DB06414	Etravirine	2	Terminated	2
DB00709	Lamivudine	2	Completed	1
DB00709	Lamivudine	2	Recruiting	2
DB11649	Lersivirine	2	Completed	2
DB11649	Lersivirine	2	Terminated	2
DB01601	Lopinavir	2	Completed	1
DB04835	Maraviroc	2	Completed	2
DB11066	Pancrelipase protease	2	Completed	1
DB06817	Raltegravir	2	Completed	1
DB08864	Rilpivirine	2	Completed	1
DB05083	Rilpivirine	2	Recruiting	2
DB08864	Rilpivirine	2	Recruiting	2
DB00503	Ritonavir	2	Completed	5
DB15623	TMC-310911	2	Completed	1
DB00300	Tenofovir disoproxil	2	Active Not Recruiting	1
DB00300	Tenofovir disoproxil	2	Completed	3
DB00300	Tenofovir disoproxil	2	Recruiting	1
DB00495	Zidovudine	2	Completed	1
DB00495	Zidovudine	2	Recruiting	1
DB00879	Emtricitabine	2 / 3	Active Not Recruiting	1
DB09299	Tenofovir alafenamide	2 / 3	Active Not Recruiting	1
DB01048	Abacavir	3	Active Not Recruiting	1
DB09065	Cobicistat	3	Active Not Recruiting	1
DB09065	Cobicistat	3	Completed	1
DB01264	Darunavir	3	Active Not Recruiting	2
DB01264	Darunavir	3	Completed	1
DB01264	Darunavir	3	Terminated	1
DB12301	Doravirine	3	Active Not Recruiting	1
DB00625	Efavirenz	3	Completed	3
DB09101	Elvitegravir	3	Completed	1
DB00879	Emtricitabine	3	Active Not Recruiting	2
DB00879	Emtricitabine	3	Completed	1
DB00879	Emtricitabine	3	Terminated	1
DB06414	Etravirine	3	Active Not Recruiting	1
DB06414	Etravirine	3	Completed	2
DB01319	Fosamprenavir	3	Terminated	1
DB00709	Lamivudine	3	Active Not Recruiting	1
DB00709	Lamivudine	3	Completed	1
DB00709	Lamivudine	3	Recruiting	1
DB01601	Lopinavir	3	Terminated	1
DB04835	Maraviroc	3	Completed	1
DB04835	Maraviroc	3	Terminated	1
DB04835	Maraviroc	3	Withdrawn	1
DB11066	Pancrelipase protease	3	Active Not Recruiting	1
DB05083	Rilpivirine	3	Completed	2
DB08864	Rilpivirine	3	Completed	2
DB00503	Ritonavir	3	Active Not Recruiting	1
DB00503	Ritonavir	3	Completed	1
DB00503	Ritonavir	3	Terminated	2
DB09299	Tenofovir alafenamide	3	Active Not Recruiting	1
DB09299	Tenofovir alafenamide	3	Completed	1
DB00300	Tenofovir disoproxil	3	Active Not Recruiting	1
DB00300	Tenofovir disoproxil	3	Terminated	1
DB00495	Zidovudine	3	Completed	1
DB01048	Abacavir	4	Completed	1
DB01072	Atazanavir	4	Completed	2
DB01264	Darunavir	4	Completed	3
DB08930	Dolutegravir	4	Completed	1
DB00625	Efavirenz	4	Completed	2
DB00879	Emtricitabine	4	Completed	4
DB01319	Fosamprenavir	4	Completed	1
DB00709	Lamivudine	4	Completed	2
DB01601	Lopinavir	4	Completed	4
DB00238	Nevirapine	4	Completed	1
DB11066	Pancrelipase protease	4	Completed	1
DB08864	Rilpivirine	4	Completed	1
DB00503	Ritonavir	4	Completed	5
DB14126	Tenofovir	4	Completed	1
DB00300	Tenofovir disoproxil	4	Completed	3
DB00495	Zidovudine	4	Completed	1
DB01264	Darunavir	Not Available	Withdrawn	1
DB00109	Enfuvirtide	Not Available	Completed	1
DB04835	Maraviroc	Not Available	Completed	1