Relapsing Multiple Sclerosis (RMS)

Also known as: Multiple Sclerosis, Relapsing Forms of Multiple Sclerosis / Relapsing multiple sclerosis (MS) / Multiple Sclerosis, Relapsing Forms / Multiple Sclerosis, Relapsing / Relapsing Multiple Sclerosis / Relapsing Forms of Multiple Sclerosis / Multiple sclerosis relapse / Multiple sclerosis flare

Drug	Drug Name	Drug Description
DB00242	Cladribine	A purine antimetabolite used for the management of relapsing forms of Multiple Sclerosis (MS), used in patients who have not responded to or who were unable to tolerate alternative MS drugs.
DB00111	Daclizumab	A monoclonal anti-CD25 antibody that blocks the interleukin-2 receptor which is used to treat relapsing forms of multiple sclerosis.
DB14783	Diroximel fumarate	A drug used for the treatment of relapsing forms of Multiple Sclerosis (MS).
DB08868	Fingolimod	A sphingosine 1-phosphate receptor modulator used to treat patients with the relapsing-remitting form of multiple sclerosis (MS) and studied to manage lung complications of COVID-19.
DB00060	Interferon beta-1a	A form of recombinant human interferon used to slow disease progression and reduce the frequency of clinical symptoms in patients who have relapsing multiple sclerosis.
DB00068	Interferon beta-1b	A form of recombinant human interferon used to slow the progression of relapsing multiple sclerosis and to reduce the frequency of clinical symptoms.
DB11988	Ocrelizumab	A CD20 specific monoclonal antibody used to treat relapsing remitting multiple sclerosis.
DB06650	Ofatumumab	An anti-CD20 antibody used for the treatment of chronic lymphocytic leukemia (CLL) in selected patients with certain treatment histories and responsiveness to anticancer medications.
DB12612	Ozanimod	A sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD).
DB09122	Peginterferon beta-1a	An interferon beta used to treat relapsing forms of multiple sclerosis.
DB12016	Ponesimod	A sphingosine 1-phosphate receptor modulator indicated to treat relapsing multiple sclerosis.
DB12371	Siponimod	A medication used to treat relapsing multiple sclerosis.

Drug	Drug Name	Target	Type
DB00242	Cladribine	Purine nucleoside phosphorylase	target
DB00242	Cladribine	DNA	target
DB00242	Cladribine	Deoxycytidine kinase	enzyme
DB00242	Cladribine	Ribonucleoside-diphosphate reductase large subunit	target
DB00242	Cladribine	Ribonucleoside-diphosphate reductase subunit M2	target
DB00242	Cladribine	Ribonucleoside-diphosphate reductase subunit M2 B	target
DB00242	Cladribine	DNA polymerase alpha catalytic subunit	target
DB00242	Cladribine	DNA polymerase epsilon catalytic subunit A	target
DB00242	Cladribine	DNA polymerase epsilon subunit 2	target
DB00242	Cladribine	DNA polymerase epsilon subunit 3	target
DB00242	Cladribine	DNA polymerase epsilon subunit 4	target
DB00242	Cladribine	ATP-binding cassette sub-family G member 2	transporter
DB00242	Cladribine	Solute carrier family 28 member 3	transporter
DB00111	Daclizumab	Interleukin-2 receptor subunit alpha	target
DB00111	Daclizumab	Low affinity immunoglobulin gamma Fc region receptor III-B	target
DB00111	Daclizumab	Complement C1r subcomponent	target
DB00111	Daclizumab	Complement C1q subcomponent subunit A	target
DB00111	Daclizumab	Complement C1q subcomponent subunit B	target
DB00111	Daclizumab	Complement C1q subcomponent subunit C	target
DB00111	Daclizumab	Low affinity immunoglobulin gamma Fc region receptor III-A	target
DB00111	Daclizumab	High affinity immunoglobulin gamma Fc receptor I	target
DB00111	Daclizumab	Low affinity immunoglobulin gamma Fc region receptor II-a	target
DB00111	Daclizumab	Interleukin-2 receptor subunit beta	target
DB00111	Daclizumab	Low affinity immunoglobulin gamma Fc region receptor II-b	target
DB00111	Daclizumab	Low affinity immunoglobulin gamma Fc region receptor II-c	target
DB14783	Diroximel fumarate	Neuronal acetylcholine receptor subunit alpha-10	target
DB08868	Fingolimod	Sphingosine 1-phosphate receptor 5	target
DB08868	Fingolimod	Sphingosine kinase 1	enzyme
DB08868	Fingolimod	Cytochrome P450 2E1	enzyme
DB08868	Fingolimod	Leukotriene-B(4) omega-hydroxylase 1	enzyme
DB08868	Fingolimod	Histone deacetylase 1	target
DB08868	Fingolimod	Excitatory amino acid transporter 2	transporter
DB08868	Fingolimod	Excitatory amino acid transporter 1	transporter
DB08868	Fingolimod	P-glycoprotein 1	transporter
DB08868	Fingolimod	Multidrug resistance-associated protein 1	transporter
DB08868	Fingolimod	Sphingosine 1-phosphate receptor 1	target
DB08868	Fingolimod	Sphingosine 1-phosphate receptor 4	target
DB08868	Fingolimod	Sphingosine 1-phosphate receptor 3	target
DB00060	Interferon beta-1a	Interferon alpha/beta receptor 1	target
DB00060	Interferon beta-1a	Interferon alpha/beta receptor 2	target
DB00060	Interferon beta-1a	Cytochrome P450 1A2	enzyme
DB00068	Interferon beta-1b	Interferon alpha/beta receptor 1	target
DB00068	Interferon beta-1b	Interferon alpha/beta receptor 2	target
DB00068	Interferon beta-1b	Cytochrome P450 1A2	enzyme
DB11988	Ocrelizumab	B-lymphocyte antigen CD20	target
DB06650	Ofatumumab	B-lymphocyte antigen CD20	target
DB12612	Ozanimod	Sphingosine 1-phosphate receptor 1	target
DB12612	Ozanimod	Sphingosine 1-phosphate receptor 5	target
DB12612	Ozanimod	Amine oxidase [flavin-containing] B	transporter
DB12612	Ozanimod	ATP-binding cassette sub-family G member 2	transporter
DB12612	Ozanimod	P-glycoprotein 1	transporter
DB12612	Ozanimod	Fatty aldehyde dehydrogenase	enzyme
DB12612	Ozanimod	Alcohol dehydrogenase class-3	enzyme
DB12612	Ozanimod	Arylamine N-acetyltransferase 2	enzyme
DB12612	Ozanimod	Cytochrome P450 2C8	enzyme
DB12612	Ozanimod	Amine oxidase [flavin-containing] B	enzyme
DB12612	Ozanimod	Aldo-keto reductase family 1 member C1	enzyme
DB12612	Ozanimod	Aldo-keto reductase family 1 member C2	enzyme
DB12612	Ozanimod	Cytochrome P450 3A4	enzyme
DB09122	Peginterferon beta-1a	Cytochrome P450 1A2	enzyme
DB09122	Peginterferon beta-1a	Interferon alpha/beta receptor 1	target
DB12016	Ponesimod	Sphingosine 1-phosphate receptor 1	target
DB12016	Ponesimod	Cytochrome P450 2J2	enzyme
DB12016	Ponesimod	Cytochrome P450 3A4	enzyme
DB12016	Ponesimod	Cytochrome P450 3A5	enzyme
DB12016	Ponesimod	Cytochrome P450 4F3	enzyme
DB12016	Ponesimod	Cytochrome P450 4F12	enzyme
DB12016	Ponesimod	UDP-glucuronosyltransferase 1-1	enzyme
DB12016	Ponesimod	UDP-glucuronosyltransferase 2B7	enzyme
DB12371	Siponimod	Sphingosine 1-phosphate receptor 5	target
DB12371	Siponimod	Sphingosine 1-phosphate receptor 1	target
DB12371	Siponimod	Cytochrome P450 3A4	enzyme
DB12371	Siponimod	Cytochrome P450 2C9	enzyme

Drug	Drug Name	Phase	Status	Count
DB00108	Natalizumab	0	Completed	1
DB00242	Cladribine	1	Completed	1
DB00242	Cladribine	1	Recruiting	1
DB00977	Ethinylestradiol	1	Completed	1
DB00977	Ethinylestradiol	1	Recruiting	1
DB12530	Inebilizumab	1	Completed	1
DB00367	Levonorgestrel	1	Completed	1
DB00367	Levonorgestrel	1	Recruiting	1
DB05092	CDP323	1 / 2	Completed	1
DB06399	Atacicept	2	Terminated	2
DB10583	Clostridium tetani toxoid antigen (formaldehyde inactivated)	2	Completed	1
DB10584	Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated)	2	Completed	1
DB08908	Dimethyl fumarate	2	Completed	1
DB18008	Etrinabdione	2	Suspended	1
DB17743	Fecal microbiota	2	Terminated	1
DB14785	Fenebrutinib	2	Active Not Recruiting	1
DB05259	Glatiramer	2	Withdrawn	1
DB00060	Interferon beta-1a	2	Withdrawn	1
DB00068	Interferon beta-1b	2	Withdrawn	1
DB06685	Laquinimod	2	Withdrawn	1
DB10061	Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine	2	Completed	1
DB13889	Meningococcal polysaccharide vaccine group A	2	Completed	1
DB13890	Meningococcal polysaccharide vaccine group C	2	Completed	1
DB13887	Meningococcal polysaccharide vaccine group W-135	2	Completed	1
DB13888	Meningococcal polysaccharide vaccine group Y	2	Completed	1
DB01204	Mitoxantrone	2	Withdrawn	1
DB00108	Natalizumab	2	Terminated	1
DB06650	Ofatumumab	2	Completed	1
DB09122	Peginterferon beta-1a	2	Withdrawn	1
DB17472	Pirtobrutinib	2	Not Yet Recruiting	1
DB10319	Streptococcus pneumoniae type 1 capsular polysaccharide antigen	2	Completed	1
DB10329	Streptococcus pneumoniae type 10a capsular polysaccharide antigen	2	Completed	1
DB10330	Streptococcus pneumoniae type 11a capsular polysaccharide antigen	2	Completed	1
DB10331	Streptococcus pneumoniae type 12f capsular polysaccharide antigen	2	Completed	1
DB10332	Streptococcus pneumoniae type 14 capsular polysaccharide antigen	2	Completed	1
DB10333	Streptococcus pneumoniae type 15b capsular polysaccharide antigen	2	Completed	1
DB10334	Streptococcus pneumoniae type 17f capsular polysaccharide antigen	2	Completed	1
DB10335	Streptococcus pneumoniae type 18c capsular polysaccharide antigen	2	Completed	1
DB10337	Streptococcus pneumoniae type 19a capsular polysaccharide antigen	2	Completed	1
DB10336	Streptococcus pneumoniae type 19f capsular polysaccharide antigen	2	Completed	1
DB10320	Streptococcus pneumoniae type 2 capsular polysaccharide antigen	2	Completed	1
DB10338	Streptococcus pneumoniae type 20 capsular polysaccharide antigen	2	Completed	1
DB10339	Streptococcus pneumoniae type 22f capsular polysaccharide antigen	2	Completed	1
DB10340	Streptococcus pneumoniae type 23f capsular polysaccharide antigen	2	Completed	1
DB10321	Streptococcus pneumoniae type 3 capsular polysaccharide antigen	2	Completed	1
DB10341	Streptococcus pneumoniae type 33f capsular polysaccharide antigen	2	Completed	1
DB10322	Streptococcus pneumoniae type 4 capsular polysaccharide antigen	2	Completed	1
DB10323	Streptococcus pneumoniae type 5 capsular polysaccharide antigen	2	Completed	1
DB10324	Streptococcus pneumoniae type 6b capsular polysaccharide antigen	2	Completed	1
DB10325	Streptococcus pneumoniae type 7f capsular polysaccharide antigen	2	Completed	1
DB10326	Streptococcus pneumoniae type 8 capsular polysaccharide antigen	2	Completed	1
DB10327	Streptococcus pneumoniae type 9n capsular polysaccharide antigen	2	Completed	1
DB10328	Streptococcus pneumoniae type 9v capsular polysaccharide antigen	2	Completed	1
DB09145	Water	2	Withdrawn	1
DB17952	CNM-Au8	2 / 3	Active Not Recruiting	1
DB12612	Ozanimod	2 / 3	Completed	1
DB00087	Alemtuzumab	3	Recruiting	1
DB00242	Cladribine	3	Recruiting	2
DB10583	Clostridium tetani toxoid antigen (formaldehyde inactivated)	3	Completed	1
DB10583	Clostridium tetani toxoid antigen (formaldehyde inactivated)	3	Recruiting	1
DB00967	Desloratadine	3	Active Not Recruiting	1
DB01234	Dexamethasone	3	Active Not Recruiting	1
DB08908	Dimethyl fumarate	3	Withdrawn	1
DB01075	Diphenhydramine	3	Active Not Recruiting	1
DB14783	Diroximel fumarate	3	Recruiting	1
DB15170	Evobrutinib	3	Active Not Recruiting	2
DB14785	Fenebrutinib	3	Active Not Recruiting	1
DB14785	Fenebrutinib	3	Recruiting	1
DB08868	Fingolimod	3	Completed	3
DB01050	Ibuprofen	3	Completed	1
DB00060	Interferon beta-1a	3	Completed	8
DB05299	Keyhole limpet hemocyanin	3	Recruiting	1
DB06685	Laquinimod	3	Terminated	2
DB00959	Methylprednisolone	3	Active Not Recruiting	1
DB00788	Naproxen	3	Completed	1
DB00108	Natalizumab	3	Recruiting	1
DB11988	Ocrelizumab	3	Active Not Recruiting	1
DB11988	Ocrelizumab	3	Completed	3
DB11988	Ocrelizumab	3	Recruiting	1
DB06650	Ofatumumab	3	Active Not Recruiting	2
DB06650	Ofatumumab	3	Completed	1
DB06650	Ofatumumab	3	Recruiting	3
DB12612	Ozanimod	3	Completed	1
DB09122	Peginterferon beta-1a	3	Completed	3
DB16852	Remibrutinib	3	Recruiting	2
DB00073	Rituximab	3	Recruiting	2
DB12371	Siponimod	3	Completed	1
DB08880	Teriflunomide	3	Active Not Recruiting	5
DB08880	Teriflunomide	3	Completed	3
DB08880	Teriflunomide	3	Recruiting	3
DB11850	Ublituximab	3	Completed	2
DB11850	Ublituximab	3	Enrolling by Invitation	1
DB11850	Ublituximab	3	Recruiting	2
DB09145	Water	3	Completed	1
DB08908	Dimethyl fumarate	4	Completed	1
DB08868	Fingolimod	4	Active Not Recruiting	1
DB08868	Fingolimod	4	Completed	2
DB05259	Glatiramer	4	Completed	1
DB05259	Glatiramer	4	Terminated	1
DB14999	Human interferon beta	4	Withdrawn	1
DB00060	Interferon beta-1a	4	Completed	2
DB00060	Interferon beta-1a	4	Withdrawn	1
DB00068	Interferon beta-1b	4	Completed	1
DB00068	Interferon beta-1b	4	Withdrawn	1
DB00108	Natalizumab	4	Terminated	1
DB11988	Ocrelizumab	4	Active Not Recruiting	2
DB11988	Ocrelizumab	4	Recruiting	1
DB06650	Ofatumumab	4	Completed	1
DB06650	Ofatumumab	4	Recruiting	1
DB06650	Ofatumumab	4	Terminated	1
DB09122	Peginterferon beta-1a	4	Withdrawn	1
DB08880	Teriflunomide	4	Completed	1
DB09145	Water	4	Completed	1
DB08908	Dimethyl fumarate	Not Available	Completed	1
DB05259	Glatiramer	Not Available	Completed	1
DB00060	Interferon beta-1a	Not Available	Completed	3
DB00108	Natalizumab	Not Available	Completed	1
DB11988	Ocrelizumab	Not Available	Completed	1
DB06650	Ofatumumab	Not Available	Completed	1
DB09122	Peginterferon beta-1a	Not Available	Completed	1