Increased Intra Ocular Pressure (IOP)

Also known as: Elevated IOP / Increased IOP / Increased ocular pressure / Raised Ocular Pressure / Intraocular pressure raised / Increased ocular tension / Elevated Intraocular Pressure / Increase in intraocular pressure (IOP) / Increase in intraocular pressure / Intraocular pressure increased / Increased intraocular pressure / Raised Intraocular Pressure / Elevation in intraocular pressure / Elevation of intraocular pressure / (Ocular hypertension) or (raised intra-ocular pressure - finding or diagnosis) / (Borderline glaucoma) or (ocular hypertension) or (increased intra-ocular pressure) / Raised intraocular pressure (finding) / IOP increased / Raised IOP / Intraocular pressure high / Ocular tension increased / Tension ocular increased / Pressure intraocular increased

DrugDrug NameDrug Description
DB00195BetaxololA cardioselective beta blocking agent commonly used to treat hypertension and elevated intraocular pressure (when administered ophthalmically).
DB00905BimatoprostA prostaglandin analog used to treat hypotrichosis of the eyelashes and intraocular pressure in open angle glaucoma or ocular hypertension.
DB00484BrimonidineAn alpha-2 adrenergic agonist used to treat glaucoma and ocular hypertension, as well as facial erythema in rosacea.
DB01194BrinzolamideA carbonic anhydrase inhibitor used for the reduction of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB00411CarbamoylcholineA direct acting miotic agent administered ophthalmically to decrease intraocular pressure after cataract surgery, and to induce miosis during surgery.
DB00521CarteololA beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma.
DB00869DorzolamideA carbonic anhydrase inhibitor used to treat high intraocular pressure in ocular hypertension and open angle glaucoma.
DB00654LatanoprostAn isopropyl ester prodrug used to treat increased intraocular pressure.
DB11660Latanoprostene bunodA prostaglandin analog used to reduce ocular hypertension or treat open-angle glaucoma.
DB00742MannitolA sugar alcohol used to test for asthma, to reduce intracranial and intraocular pressure, to measure glomerular filtration rate, and to manage pulmonary symptoms associated with cystic fibrosis.
DB13931NetarsudilA rho kinase inhibitor used to reduce intraocular pressure in patients with open angle glaucoma or ocular hypertension.
DB01085PilocarpineA muscarinic cholinergic agonist used on the eye to treat elevated intraocular pressure, various types of glaucoma, and to induce miosis. Also available orally to treat symptoms of dry mouth associated with Sjogren's syndrome and radiotherapy.
DB09153Sodium chlorideAn ingredient found in a variety of nutritional products as a source of electrolytes and water.
DB08819TafluprostAn ophthalmic prostaglandin analog used to lower intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
DB00373TimololA non-selective beta adrenergic blocker used in the treatment of elevated intraocular pressure in ocular hypertension or open angle glaucoma.
DB00287TravoprostA prostaglandin analog used in the treatment of elevated intraocular pressure due to open angle glaucoma or ocular hypertension.
DrugDrug NameTargetType
DB00195BetaxololBeta-1 adrenergic receptortarget
DB00195BetaxololBeta-2 adrenergic receptortarget
DB00195BetaxololCytochrome P450 1A2enzyme
DB00195BetaxololCytochrome P450 2D6enzyme
DB00905BimatoprostProstaglandin F2-alpha receptortarget
DB00905BimatoprostProstaglandin E2 receptor EP1 subtypetarget
DB00905BimatoprostProstaglandin E2 receptor EP3 subtypetarget
DB00905BimatoprostCytochrome P450 3A4enzyme
DB00905BimatoprostCytochrome P450 3A5enzyme
DB00484BrimonidineAlpha-2A adrenergic receptortarget
DB00484BrimonidineAlpha-2B adrenergic receptortarget
DB00484BrimonidineAlpha-2C adrenergic receptortarget
DB00484BrimonidineAldehyde oxidaseenzyme
DB01194BrinzolamideCarbonic anhydrase 1target
DB01194BrinzolamideCarbonic anhydrase 2target
DB01194BrinzolamideCytochrome P450 3A4enzyme
DB01194BrinzolamideCarbonic anhydrase 5A, mitochondrialtarget
DB01194BrinzolamideCarbonic anhydrase 4target
DB01194BrinzolamideCarbonic anhydrase 3target
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M1target
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M2target
DB00411CarbamoylcholineNeuronal acetylcholine receptor subunit alpha-2target
DB00411CarbamoylcholineCytosolic phospholipase A2enzyme
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M3target
DB00411CarbamoylcholineMuscarinic acetylcholine receptor M4target
DB00411CarbamoylcholineAcetylcholinesteraseenzyme
DB00521CarteololBeta-2 adrenergic receptortarget
DB00521CarteololBeta-1 adrenergic receptortarget
DB00521CarteololCytochrome P450 2D6enzyme
DB00869DorzolamideCarbonic anhydrase 2target
DB00869DorzolamideCarbonic anhydrase 1target
DB00869DorzolamideCarbonic anhydrase 4target
DB00869DorzolamideCytochrome P450 2C9enzyme
DB00869DorzolamideCarbonic anhydrase 3target
DB00869DorzolamideCytochrome P450 2B1enzyme
DB00869DorzolamideCytochrome P450 2E1enzyme
DB00869DorzolamideCytochrome P450 3A2enzyme
DB00654LatanoprostProstaglandin F2-alpha receptortarget
DB00654LatanoprostSolute carrier organic anion transporter family member 2A1transporter
DB00654LatanoprostSolute carrier family 22 member 6transporter
DB00654LatanoprostSolute carrier family 22 member 8transporter
DB00654LatanoprostCorneal esterasesenzyme
DB11660Latanoprostene bunodProstaglandin F2-alpha receptortarget
DB11660Latanoprostene bunodSolute carrier organic anion transporter family member 2B1transporter
DB00742MannitolMannitol dehydrogenaseenzyme
DB13931NetarsudilRho-associated protein kinase 1target
DB13931NetarsudilRho-associated protein kinase 2target
DB13931NetarsudilSodium-dependent noradrenaline transportertarget
DB01085PilocarpineMuscarinic acetylcholine receptor M1target
DB01085PilocarpineMuscarinic acetylcholine receptor M2target
DB01085PilocarpineCytochrome P450 2A6enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M3target
DB01085PilocarpineCytochrome P450 3A4enzyme
DB01085PilocarpineMuscarinic acetylcholine receptor M4target
DB08819TafluprostProstaglandin F2-alpha receptortarget
DB08819TafluprostProstaglandin G/H synthase 2enzyme
DB00373TimololBeta-1 adrenergic receptortarget
DB00373TimololBeta-2 adrenergic receptortarget
DB00373TimololCytochrome P450 2D6enzyme
DB00373TimololP-glycoprotein 1transporter
DB00373TimololCytochrome P450 2C19enzyme
DB00373TimololLysozymetarget
DB00287TravoprostProstaglandin F2-alpha receptortarget
DrugDrug NamePhaseStatusCount
DB05757DNB-0011 / 2Completed1
DB14875AZD-40172Completed1
DB00654Latanoprost2Completed1
DB00654Latanoprost3Active Not Recruiting1
DB00653Magnesium sulfate3Completed1