Opioid Detoxification

Drug	Drug Name	Drug Description
DB00333	Methadone	An opioid analgesic indicated for management of severe pain that is not responsive to alternative treatments. Also used to aid in detoxification and maintenance treatment of opioid addiction.

Drug	Drug Name	Target	Type
DB00333	Methadone	NMDA receptor	target
DB00333	Methadone	Mu-type opioid receptor	target
DB00333	Methadone	Cytochrome P450 2B6	enzyme
DB00333	Methadone	Cytochrome P450 3A4	enzyme
DB00333	Methadone	Cytochrome P450 2C19	enzyme
DB00333	Methadone	Delta-type opioid receptor	target
DB00333	Methadone	Cytochrome P450 3A7	enzyme
DB00333	Methadone	Cytochrome P450 2D6	enzyme
DB00333	Methadone	P-glycoprotein 1	transporter
DB00333	Methadone	Cytochrome P450 2C8	enzyme
DB00333	Methadone	Cytochrome P450 19A1	enzyme
DB00333	Methadone	Cytochrome P450 1A2	enzyme
DB00333	Methadone	Cytochrome P450 2C18	enzyme
DB00333	Methadone	Cytochrome P450 2C9	enzyme
DB00333	Methadone	5-hydroxytryptamine receptor 3A	target
DB00333	Methadone	Alpha-1-acid glycoprotein 1	carrier
DB00333	Methadone	Serum albumin	carrier
DB00333	Methadone	Neuronal acetylcholine receptor subunit alpha-7	target
DB00333	Methadone	Neuronal acetylcholine receptor subunit alpha-3	target
DB00333	Methadone	Neuronal acetylcholine receptor subunit alpha-4	target
DB00333	Methadone	Neuronal acetylcholine receptor subunit beta-2	target
DB00333	Methadone	Cytochrome P450 3A Subfamily	enzyme
DB00333	Methadone	UDP-glucuronosyltransferase 2B4	enzyme

Drug	Drug Name	Phase	Status	Count
DB00921	Buprenorphine	2	Completed	1
DB00996	Gabapentin	2	Completed	1
DB01183	Naloxone	2	Completed	1