Huntington's Disease (HD)

Also known as: Huntington's Dementia / Huntington Chorea / Huntingtons Disease / Huntington's chorea / Chorea, Huntington / Huntington Disease / Huntington's Disease / Chorea Associated With Huntington Disease / Huntington's chorea (disorder)

Drug	Drug Name	Drug Description
DB12161	Deutetrabenazine	A vesicular monoamine transporter 2 inhibitor used for the symptomatic treatment of tardive dyskinesia and chorea associated with Huntington's disease.
DB00623	Fluphenazine	A phenothiazine used to treat patients requiring long-term neuroleptic therapy.
DB00502	Haloperidol	An antipsychotic agent used to treat schizophrenia and other psychoses, as well as symptoms of agitation, irritability, and delirium.
DB04844	Tetrabenazine	A vesicular monoamine transporter 2 (VMAT) inhibitor used for the management of chorea associated with Huntington's Disease.
DB13025	Tiapride	A dopamine D2 and D3 receptor antagonist indicated in the treatment of chorea in Huntington's disease, as well as agitation and anxiety in the elderly or with acute or chronic alcoholism.
DB11915	Valbenazine	A vesicular monoamine transporter 2 inhibitor used to treat tardive dyskinesia and chorea associated with Huntington's disease.

Drug	Drug Name	Target	Type
DB12161	Deutetrabenazine	Synaptic vesicular amine transporter	target
DB12161	Deutetrabenazine	Carbonyl reductase [NADPH] 1	enzyme
DB12161	Deutetrabenazine	Carbonyl reductase [NADPH] 3	enzyme
DB12161	Deutetrabenazine	Cytochrome P450 2D6	enzyme
DB12161	Deutetrabenazine	Cytochrome P450 1A2	enzyme
DB12161	Deutetrabenazine	Cytochrome P450 3A5	enzyme
DB12161	Deutetrabenazine	Cytochrome P450 3A4	enzyme
DB00623	Fluphenazine	Dopamine D2 receptor	target
DB00623	Fluphenazine	Calmodulin	target
DB00623	Fluphenazine	Dopamine D1 receptor	target
DB00623	Fluphenazine	Cytochrome P450 2D6	enzyme
DB00623	Fluphenazine	P-glycoprotein 1	transporter
DB00623	Fluphenazine	Cytochrome P450 2E1	enzyme
DB00623	Fluphenazine	Androgen receptor	target
DB00623	Fluphenazine	5-hydroxytryptamine receptor 2A	target
DB00623	Fluphenazine	5-hydroxytryptamine receptor 2C	target
DB00502	Haloperidol	Dopamine D2 receptor	target
DB00502	Haloperidol	Glutamate receptor ionotropic, NMDA 2B	target
DB00502	Haloperidol	Dopamine D1 receptor	target
DB00502	Haloperidol	Cytochrome P450 1A2	enzyme
DB00502	Haloperidol	Cytochrome P450 2D6	enzyme
DB00502	Haloperidol	5-hydroxytryptamine receptor 2A	target
DB00502	Haloperidol	Dopamine D3 receptor	target
DB00502	Haloperidol	Cytochrome P450 3A4	enzyme
DB00502	Haloperidol	Cytochrome P450 3A5	enzyme
DB00502	Haloperidol	Cytochrome P450 3A7	enzyme
DB00502	Haloperidol	P-glycoprotein 1	transporter
DB00502	Haloperidol	Carbonyl reductase [NADPH] 1	enzyme
DB00502	Haloperidol	UDP-glucuronosyltransferase 1-9	enzyme
DB00502	Haloperidol	Cytochrome P450 2C19	enzyme
DB00502	Haloperidol	Cytochrome P450 2C9	enzyme
DB00502	Haloperidol	Melanin-concentrating hormone receptor 1	target
DB00502	Haloperidol	Synaptic vesicular amine transporter	target
DB00502	Haloperidol	5-hydroxytryptamine receptor 2C	target
DB00502	Haloperidol	Sigma non-opioid intracellular receptor 1	target
DB00502	Haloperidol	Histamine H1 receptor	target
DB00502	Haloperidol	Muscarinic acetylcholine receptor M3	target
DB00502	Haloperidol	Alpha-1A adrenergic receptor	target
DB00502	Haloperidol	Alpha-2A adrenergic receptor	target
DB00502	Haloperidol	Alpha-2B adrenergic receptor	target
DB00502	Haloperidol	Alpha-2C adrenergic receptor	target
DB00502	Haloperidol	5-hydroxytryptamine receptor 1A	target
DB00502	Haloperidol	5-hydroxytryptamine receptor 6	target
DB00502	Haloperidol	5-hydroxytryptamine receptor 7	target
DB00502	Haloperidol	Cytochrome P450 1A1	enzyme
DB04844	Tetrabenazine	Synaptic vesicular amine transporter	target
DB04844	Tetrabenazine	Cytochrome P450 2D6	enzyme
DB04844	Tetrabenazine	Dopamine D2 receptor	target
DB04844	Tetrabenazine	Carbonyl reductase [NADPH] 1	enzyme
DB13025	Tiapride	Dopamine D2 receptor	target
DB13025	Tiapride	Dopamine D3 receptor	target
DB13025	Tiapride	Serotonin Receptors	target
DB13025	Tiapride	Alpha-1 adrenergic receptors	target
DB13025	Tiapride	Alpha-2 adrenergic receptors	target
DB11915	Valbenazine	Synaptic vesicular amine transporter	target
DB11915	Valbenazine	Cytochrome P450 2D6	enzyme
DB11915	Valbenazine	Cytochrome P450 3A4	enzyme
DB11915	Valbenazine	Cytochrome P450 3A5	enzyme

Drug	Drug Name	Phase	Status	Count
DB18165	ER2001	0	Recruiting	1
DB00404	Alprazolam	1	Completed	1
DB18235	CKD-504	1	Unknown Status	1
DB12161	Deutetrabenazine	1	Not Yet Recruiting	1
DB12161	Deutetrabenazine	1	Recruiting	1
DB00514	Dextromethorphan	1	Completed	1
DB00390	Digoxin	1	Completed	1
DB13134	Fluorine F-18	1	Completed	1
DB12542	GSK-356278	1	Completed	2
DB00502	Haloperidol	1	Recruiting	1
DB09081	Idebenone	1	Recruiting	1
DB01026	Ketoconazole	1	Completed	1
DB11725	Latrepirdine	1	Completed	9
DB04868	Nilotinib	1	Unknown Status	1
DB00338	Omeprazole	1	Completed	1
DB00734	Risperidone	1	Recruiting	1
DB01954	Rolipram	1	Completed	1
DB01104	Sertraline	1	Recruiting	1
DB17924	Tominersen	1	Completed	1
DB01586	Ursodeoxycholic acid	1	Unknown Status	1
DB00682	Warfarin	1	Completed	1
DB00148	Creatine	1 / 2	Completed	1
DB11725	Latrepirdine	1 / 2	Completed	1
DB17933	Lexanersen	1 / 2	Terminated	2
DB01017	Minocycline	1 / 2	Completed	1
DB16982	Rovanersen	1 / 2	Terminated	2
DB18160	VO659	1 / 2	Recruiting	1
DB17870	WVE-003	1 / 2	Recruiting	1
DB16977	ANX-005	2	Completed	1
DB06151	Acetylcysteine	2	Not Yet Recruiting	1
DB00915	Amantadine	2	Completed	1
DB00289	Atomoxetine	2	Completed	1
DB01295	Bevantolol	2	Recruiting	1
DB00121	Biotin	2	Recruiting	1
DB01156	Bupropion	2	Completed	1
DB09061	Cannabidiol	2	Completed	1
DB00215	Citalopram	2	Completed	1
DB00148	Creatine	2	Completed	3
DB00470	Dronabinol	2	Completed	1
DB01039	Fenofibrate	2	Completed	1
DB06685	Laquinimod	2	Completed	1
DB11725	Latrepirdine	2	Completed	1
DB14509	Lithium carbonate	2	Completed	1
DB08387	Mardepodect	2	Completed	2
DB08387	Mardepodect	2	Terminated	1
DB13004	Mavoglurant	2	Terminated	1
DB01043	Memantine	2	Completed	1
DB07138	Neflamapimod	2	Terminated	1
DB17874	OMS-824	2	Terminated	1
DB15155	Pepinemab	2	Completed	1
DB06819	Phenylbutyric acid	2	Completed	1
DB11947	Pridopidine	2	Completed	3
DB11947	Pridopidine	2	Terminated	1
DB00734	Risperidone	2	Completed	1
DB16968	SRX-246	2	Completed	1
DB00152	Thiamine	2	Recruiting	1
DB17924	Tominersen	2	Completed	1
DB17924	Tominersen	2	Recruiting	1
DB11677	Triheptanoin	2	Completed	2
DB09270	Ubidecarenone	2	Completed	1
DB00313	Valproic acid	2	Completed	1
DB12161	Deutetrabenazine	2 / 3	Recruiting	1
DB01017	Minocycline	2 / 3	Completed	1
DB12161	Deutetrabenazine	3	Completed	1
DB00514	Dextromethorphan	3	Completed	1
DB09341	Dextrose, unspecified form	3	Terminated	1
DB08887	Icosapent ethyl	3	Completed	1
DB11725	Latrepirdine	3	Completed	1
DB11725	Latrepirdine	3	Terminated	1
DB00331	Metformin	3	Recruiting	1
DB00334	Olanzapine	3	Completed	1
DB11947	Pridopidine	3	Active Not Recruiting	1
DB11947	Pridopidine	3	Completed	1
DB00908	Quinidine	3	Completed	1
DB00740	Riluzole	3	Completed	1
DB04844	Tetrabenazine	3	Completed	1
DB13025	Tiapride	3	Completed	1
DB17924	Tominersen	3	Completed	2
DB09270	Ubidecarenone	3	Terminated	1
DB11915	Valbenazine	3	Active Not Recruiting	1
DB11915	Valbenazine	3	Completed	1
DB11915	Valbenazine	3	Enrolling by Invitation	1
DB01043	Memantine	4	Completed	1
DB04844	Tetrabenazine	4	Completed	1
DB04844	Tetrabenazine	4	Recruiting	1
DB00915	Amantadine	Not Available	Recruiting	1
DB00190	Carbidopa	Not Available	Recruiting	1
DB00494	Entacapone	Not Available	Recruiting	1
DB01235	Levodopa	Not Available	Recruiting	1
DB00413	Pramipexole	Not Available	Recruiting	1
DB00980	Ramelteon	Not Available	Withdrawn	1
DB00268	Ropinirole	Not Available	Recruiting	1
DB00323	Tolcapone	Not Available	Recruiting	1