Stage 3 Chronic Kidney Disease

Also known as: Chronic Kidney Disease, Stage 3 (Moderate) / Chronic Kidney Disease Stage 3 / Chronic Kidney Disease, Stage 3 / Chronic Kidney Disease stage3 / Chronic kidney disease stage 3 (disorder) / Chronic kidney disease, unspecified / Chronic kidney disease / Chronic Kidney Diseases / Chronic kidney disease (CKD) / Chronic kidney disease (disorder)

Drug	Drug Name	Drug Description
DB00146	Calcifediol	An active metabolite of vitamin D used to treat hyperparathyroidism as well as to combat hypocalcemia in dialysis patients.
DB06410	Doxercalciferol	A synthetic vitamin D2 analog used to treat secondary hyperparathyroidism in patients with chronic kidney disease with or without therapy of dialysis.
DB16165	Finerenone	A nonsteroidal mineralocorticoid receptor antagonist indicated to lower the risk of eGFR decline, end stage kidney disease, cardiovascular death, heart attack, and hospitalization for heart failure in chronic kidney disease associated with type 2 diabetes.
DB00910	Paricalcitol	A vitamin D analog used to treat hyperparathyroidism associated with stage 3 or greater chronic kidney disease.

Drug	Drug Name	Target	Type
DB00146	Calcifediol	25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial	enzyme
DB00146	Calcifediol	Vitamin D3 receptor	target
DB00146	Calcifediol	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	enzyme
DB06410	Doxercalciferol	Sterol 26-hydroxylase, mitochondrial	enzyme
DB06410	Doxercalciferol	Vitamin D3 receptor	target
DB16165	Finerenone	Cytochrome P450 3A4	enzyme
DB16165	Finerenone	Cytochrome P450 2C8	enzyme
DB16165	Finerenone	Serum albumin	carrier
DB16165	Finerenone	Mineralocorticoid receptor	target
DB16165	Finerenone	Cytochrome P450 1A1	enzyme
DB00910	Paricalcitol	Vitamin D3 receptor	target
DB00910	Paricalcitol	1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	enzyme
DB00910	Paricalcitol	Cytochrome P450 3A4	enzyme
DB00910	Paricalcitol	UDP-glucuronosyltransferase 1-4	enzyme

Drug	Drug Name	Phase	Status	Count
DB15122	PCS-499	1	Completed	1
DB12422	Sulforaphane	1 / 2	Completed	1
DB09278	Activated charcoal	2	Unknown Status	1
DB09038	Empagliflozin	2	Completed	1
DB00936	Salicylic acid	2	Completed	1
DB12422	Sulforaphane	2	Recruiting	1
DB00945	Acetylsalicylic acid	3	Unknown Status	1
DB00146	Calcifediol	3	Recruiting	1
DB00012	Darbepoetin alfa	3	Completed	1
DB16135	Desidustat	3	Completed	1
DB12713	Sotagliflozin	3	Completed	1
DB00136	Calcitriol	4	Completed	1
DB06724	Calcium carbonate	4	Completed	1
DB11574	Elbasvir	4	Completed	1
DB09038	Empagliflozin	4	Not Yet Recruiting	1
DB16165	Finerenone	4	Not Yet Recruiting	1
DB11575	Grazoprevir	4	Completed	1
DB00151	Cysteine	Not Available	Completed	1
DB09038	Empagliflozin	Not Available	Recruiting	1
DB04854	Febuxostat	Not Available	Completed	1