Castleman Disease
Also known as: Giant Lymph Node Hyperplasia / Angiofollicular Lymph Node Hyperplasia / Castleman's Disease (CD) / Castleman's Disease / Angiofollicular lymph node hyperplasia (morphologic abnormality) / Angiofollicular lymph node hyperplasia (disorder) / Angiofollicular lymph node hyperplasia (disorder) [Ambiguous] / [D] Castleman's disease (disorder) / Giant lymph node hyperplasia (disorder)
| Drug | Drug Name | Drug Description |
|---|---|---|
| DB09036 | Siltuximab | An interleukin antagonist used to treat multicentric Castleman's disease (MCD) in patients who are HIV and HHV-8 negative. |
| Drug | Drug Name | Target | Type |
|---|---|---|---|
| DB09036 | Siltuximab | Interleukin-6 | target |
| DB09036 | Siltuximab | Cytochrome P450 3A4 | enzyme |
| Drug | Drug Name | Phase | Status | Count |
|---|---|---|---|---|
| DB00220 | Nelfinavir | 0 | Terminated | 1 |
| DB00112 | Bevacizumab | 1 | Active Not Recruiting | 1 |
| DB00002 | Cetuximab | 1 | Active Not Recruiting | 1 |
| DB15408 | Silmitasertib | 1 | Unknown Status | 1 |
| DB09036 | Siltuximab | 1 | Completed | 1 |
| DB06287 | Temsirolimus | 1 | Active Not Recruiting | 1 |
| DB06273 | Tocilizumab | 1 | Completed | 1 |
| DB00313 | Valproic acid | 1 | Active Not Recruiting | 1 |
| DB00073 | Rituximab | 2 | Terminated | 1 |
| DB00877 | Sirolimus | 2 | Recruiting | 1 |
| DB06273 | Tocilizumab | 2 | Completed | 1 |
| DB01610 | Valganciclovir | 2 | Completed | 1 |
| DB00495 | Zidovudine | 2 | Completed | 1 |
| DB01610 | Valganciclovir | 4 | Withdrawn | 1 |