Overactive Detrusor Function

Also known as: Detrusor Overactivity / Detrusor, Overactive / Detrusor Muscle Hyperactivity / Detrusor Function, Overactive / Overactive Detrusor / Detrusor Hyperreflexia of Bladder / Detruser overactivity / Detrusor spasm / Detrusor Hyperreflexia / Detrusor overactivity (disorder) / Neurogenic detrusor overactivity (disorder) / Overactive bladder / Overactive bladder (disorder) / Hypertonic bladder / Hyperactive bladder / Urinary Bladder, Overactive / Hypertonicity of bladder / Low compliance bladder (disorder)

Drug	Drug Name	Drug Description
DB00572	Atropine	A muscarinic antagonist used to treat poisoning by muscarinic agents, including organophosphates and other drugs.
DB01062	Oxybutynin	An antimuscarinic agent that reduces detrusor muscle activity, relaxing the bladder and preventing the urge to void.

Drug	Drug Name	Target	Type
DB00572	Atropine	Muscarinic acetylcholine receptor M2	target
DB00572	Atropine	Muscarinic acetylcholine receptor M1	target
DB00572	Atropine	Muscarinic acetylcholine receptor M4	target
DB00572	Atropine	Muscarinic acetylcholine receptor M5	target
DB00572	Atropine	Muscarinic acetylcholine receptor M3	target
DB00572	Atropine	Glycine receptor subunit alpha-1	target
DB00572	Atropine	Neuronal acetylcholine receptor subunit alpha-4	target
DB00572	Atropine	Neuronal acetylcholine receptor subunit beta-2	target
DB00572	Atropine	Bile salt export pump	transporter
DB00572	Atropine	Alpha-1-acid glycoprotein 1	carrier
DB01062	Oxybutynin	Muscarinic acetylcholine receptor M1	target
DB01062	Oxybutynin	Muscarinic acetylcholine receptor M2	target
DB01062	Oxybutynin	Muscarinic acetylcholine receptor M3	target
DB01062	Oxybutynin	Cytochrome P450 3A4	enzyme
DB01062	Oxybutynin	Cytochrome P450 2C8	enzyme
DB01062	Oxybutynin	Cytochrome P450 2D6	enzyme
DB01062	Oxybutynin	Cytochrome P450 3A5	enzyme
DB01062	Oxybutynin	Alpha-1-acid glycoprotein 1	carrier
DB01062	Oxybutynin	Serum albumin	carrier

Drug	Drug Name	Phase	Status	Count
DB00083	Botulinum toxin type A	1 / 2	Completed	1
DB01093	Dimethyl sulfoxide	1 / 2	Completed	1
DB00083	Botulinum toxin type A	2	Completed	1
DB00496	Darifenacin	2	Terminated	1
DB00862	Vardenafil	2	Completed	1
DB00083	Botulinum toxin type A	3	Terminated	2
DB09061	Cannabidiol	3	Completed	1
DB01093	Dimethyl sulfoxide	3	Terminated	1
DB00470	Dronabinol	3	Completed	1
DB14011	Nabiximols	3	Completed	1
DB12278	Propiverine	3	Completed	1
DB00083	Botulinum toxin type A	4	Unknown Status	1
DB01075	Diphenhydramine	4	Unknown Status	1
DB00281	Lidocaine	4	Unknown Status	1
DB01062	Oxybutynin	4	Completed	3
DB01062	Oxybutynin	4	Terminated	1
DB01438	Phenazopyridine	4	Unknown Status	1
DB01591	Solifenacin	4	Completed	1
DB16098	Atogepant	Not Available	Enrolling by Invitation	1
DB00083	Botulinum toxin type A	Not Available	Completed	1
DB00083	Botulinum toxin type A	Not Available	Enrolling by Invitation	1
DB14040	Eptinezumab	Not Available	Enrolling by Invitation	1
DB14039	Erenumab	Not Available	Enrolling by Invitation	1
DB14041	Fremanezumab	Not Available	Enrolling by Invitation	1
DB14042	Galcanezumab	Not Available	Enrolling by Invitation	1
DB08893	Mirabegron	Not Available	Not Yet Recruiting	1
DB12457	Rimegepant	Not Available	Enrolling by Invitation	1
DB01591	Solifenacin	Not Available	Not Yet Recruiting	1
DB15328	Ubrogepant	Not Available	Enrolling by Invitation	1